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| 1 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 2 | Residual alkalinity as tracer to estimate the changes indueed by forage cultivation in a non-saline irrigated sodic soil显示文摘 | Laurent B Vincent V Annick R | 2001 | Agricultural Water Management2001，50，3： | 1 |
| 3 | SRAP Polymorphisms Associated to Cell Wall Degradability in Lignified Stems of Alfalfa显示文摘 | Marie-Pier Dubé Yves Castonguay Marc-Olivier Duceppe Annick Bertrand Réal Michaud | 2013 | BioEnergy Research2013，，2： | 1 |
| 4 | Genetics and genomics of flower initiation and development in roses 显示文摘 | Mohammed B Annick D Oliver R | 2013 | Journal of Experimental Botany2013，64，4： | 1 |
| 5 | Comparison and analysis the quality concentration and the activation concentration of CKMB in the AMI 显示文摘 | Jans R D Annick M D M Mare L D B | 2000 | AmColl Cardiol2000，35，： | 1 |
| 6 | A Improved specific detection of Vibrio cholerae in environmental water samples by culture on selective medium and colony hybridization assay with an oligonucleotide probe显示文摘 | ANNICK R P A SANDRINE B B | 2002 | FEMS Microbiology Ecology2002，40，： | 1 |
| 7 | Improved specific detectionof Vibrio cholerae in environmental water samples by culture onselective medium and colony hybridization assay with an oligonucleotide probe显示文摘 | ANNICK R P A SANDRINE B B A | 2002 | FEMS Microbiology Ecology2002，，40： | 1 |
| 8 | The cellulolytic microflora of the human colon:evidence of microcrystalline cellulose-degrading bacteria in methane-excreting subjects显示文摘 | Celine R Annick B D | 2003 | FEMS Microbiology Ecolo- gy2003，46，1： | 1 |
| 9 | Safety improvement and preservation of typical sensory qualities of traditional dry fermented sausages using autochthonous starter cultures显示文摘 | Régine Talon Sabine Leroy Isabelle Lebert Philippe Giammarinaro Jean-Paul Chacornac Mariluz Latorre-Moratalla Carmen Vidal-Carou Emanuela Zanardi Mauro Conter Annick Lebecque | 2008 | International Journal of Food Microbiology2008，，1： | 1 |
| 10 | Mineral Paragene- sis, Alteration, and Geochemistry of the Two Types of Gold Ore and the Host Rocks from the Carlin - Type Deposits in the South- ern Part of the Goldstrike Property, Northern Nevada: Implications for Sources of Ore - Forming Elements, Ore Genesis, and Mineral Exploration显示文摘 | Carolina M A Gema R O Annick C H | 2010 | Economic Geology2010，，105： | 1 |
| 11 | Anti-hepatitis C virus drugs and kidney显示文摘Hepatitis C virus(HCV) mainly targets the liver but can also induce extrahepatic manifestations. The kidney may be impacted via an immune mediated mechanism or a cytopathic effect. HCV patients are clearly at a greater risk of chronic kidney disease(CKD) than uninfected patients are, and the presence of CKD increases mortality. Interferon-based therapies and ribavirin are difficult to manage and are poorly effective in endstage renal disease and hemodialysis. These patients should be given priority treatment with new direct anti-viral agents(DAAs) while avoiding peginterferon and ribavirin. The first results were convincing. To aid in the correct use of these drugs in patients with renal insufficiency, their pharmacokinetic properties and potential renal toxicity must be known. The renal toxicity of these new drugs was not a safety signal in clinical trials, and the drugs are generally efficient in these frail populations. These drugs are usually well tolerated, but recent cohort studies have demonstrated that these new regimens may be associated with renal side effects, especially when using sofosbuvir combinations. HCV, renal diseases and comorbidities are intimately linked. The close monitoring of renal function is required, particularly for at-risk patients(transplanted, HIV-coinfected, CKD, hypertensive or diabetic patients). New DAA regimens, which will soon be approved, will probably change the landscape. | Paul Carrier Marie Essig Marilyne Debette-Gratien Denis Sautereau Annick Rousseau Pierre Marquet Jérémie Jacques Véronique Loustaud-Ratti | 2016 | World Journal of Hepatology2016，8，32： | 0 |
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