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| 1 | Endocytosis unplugged: multiple ways to enter the cell显示文摘Endocytosis 在房间表面发生并且与它的成分膜蛋白质和类脂化合物一起包含血浆膜(下午) 的成为主观。Endocytosis 涉及细胞外的周围的采样并且也服务调整在房间表面开始的各种各样的过程。这些包括滋养的举起,从房间表面受体,和为在 metazoans 工作的房间和织物的许多另外的过程必需品发信号。它对下午类脂化合物和蛋白质动态平衡的维护也中央。有成为主观的多重工具并发地操作,在房间表面。与在高分辨率的可视化技术的前进,同时追踪多重 endocytic 货物现在是可能的,揭示在一个单个房间的 endocytic 进程的显著差异。实时房间成像和有效基因操作的联合也帮助了在成为主观的这些机制理解分子的播放器的功能的层次。这里,我们提供各种各样的 endocytic 线路的一篇报道,他们越过数的操作和出现的机制。 | Sudha Kumari Swetha MG Satyajit Mayor | 2010 | Cell Research2010,20,3: | 19 |
| 2 | COX-2 in liver,from regeneration to hepatocarcinogenesis:What we have learned from animal models?显示文摘The use of animals lacking genes or expressing genes under the control of cell-specific promoters has signifi cantly increased our knowledge of the genetic and molecular basis of physiopathology,allowing testing of functional hypotheses and validation of biochemical and pharmacologic approaches in order to understand cell function.However,with unexpected frequency,gene knockout animals and,more commonly,animal models of transgenesis give experimental support to even opposite conclusions on gene function.Here we summarize what we learned on the role of cyclooxygenase 2(COX-2) in liver and revise the results obtained in 3 independent models of mice expressing a COX-2 transgene specifi cally in the hepatocyte.Upon challenge with pro-inflammatory stimuli,the animals behave very differently,some transgenic models having a protective effect but others enhancing the injury.In addition,one transgene exerts differential effects on normal liver physiology depending on the transgenic animal model used. | Paloma Martín-Sanz Rafael Mayoral Marta Casado Lisardo Boscá | 2010 | World Journal of Gastroenterology2010,16,12: | 12 |
| 3 | 认知行为治疗对大脑活动的影响有别于抗抑郁药显示文摘一项小型预试验首次根据脑扫描的证据证明,不同的治疗方式作用于不同途径。该试验报道与抗抑郁药帕罗西汀治疗不同,认知行为治疗启动了一种变化了的大脑活动模式。 研究人员对17例未经治疗的单相抑郁症门诊患者在接受15-20次认知行为治疗之前和之后进行了脑扫描。 | Sue Mayor 张新凯 | 2004 | 英国医学杂志中文版2004,7,4: | 8 |
| 4 | Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2显示文摘G 联合蛋白质的受体 kinase (GRK2 ) 2 是调整不同的膜 receptorsand 的重要 serine/threonine-kinase 细胞内部的蛋白质。在胚胎或成年苍蝇的果蝇 Gprk2 的变细导致了体的肌肉,纤维的损失,和不能飞行的 phenotype.In 的有缺点的区别脊椎动物, GRK2 hemizygous 老鼠少些,但是更包含了 hypertrophied 骨胳的肌肉纤维比野类型的 littermates.In C2C12 myoblasts , GRK2 kinase缺乏的异种( K220R )的 overexpression 引起了房间 intoimmature myotubes 的早熟的区别,它在尺寸是更宽的并且包含了更多的熔化原子核,当时 GRK2 overexpression b 熔化事件由提高的 GRK2 层次支持了的损害 differentiationand 少数被 p38MAPK 异种概括,它能由 GRK2 模仿 p38MAPK 的 theinhibitory phosphorylation,而在表示 GRK2 观察的弄钝的区别面对 p38MAPK 小径的一个组成地活跃的在上游的激发器克隆 wasrescued。这些结果建议 thatbalanced GRK2 功能为一个及时、完全的 myogenic 过程是必要的。 | Lucia Garcia-Guerra Rocio Vila-Bedmar Marta Carrasco-Rando Marta Cruces-Sande Mercedes Martin Ana Ruiz-Gomez Mar Ruiz-Gomez Margarita Lorenzo Sonia Fernandez-Veledo Federico Mayor Jr. Cristina Murga Iria Nieto-Vazquez | 2014 | Journal of Molecular Cell Biology2014,8,4: | 3 |
| 5 | 综述报道:听音乐可缓解术后疼痛及焦虑显示文摘Lancet刊登了一篇综述报道:术前、术中及术后听音乐可明显缓解患者的疼痛及焦虑,以及减少患者镇痛药物的使用。 | Susan Mayor 马岩 | 2015 | 英国医学杂志中文版2015,0,12: | 3 |
| 6 | 外科杂志封杀隐瞒利益冲突的作者显示文摘《胸心外科杂志》(The Journal of Thoracic and Cardiovascular)编辑,美国费城Drexel大学医学院心胸外科系主任,Andrew Wechsler近日宣布,故意隐瞒利益冲突的作者至少一年内不得在该杂志再次发表文章,以强调他们充分公开的重要性。 | Susan Mayor 罗丹 | 2006 | 英国医学杂志中文版2006,9,4: | 1 |
| 7 | Spatial shift-share analysis versus spatial filtering: an application to Spanish employment data 显示文摘 | Matias Mayor Ana Jesus Lopez | 2008 | Empirical Economics2008,,34: | 1 |
| 8 | Recognition of a protein fold in the context of the SCOP classification 显示文摘 | Dubchak I Muchnik I Mayor C | 1999 | Proteins: Structure Function and Genetics1999,35,4: | 1 |
| 9 | The Colorado thyroid disease prevalence study 显示文摘 | Canaris G J Manowitz N R Mayor G | 2000 | Arch Int Med2000,160,4: | 1 |
| 10 | Mechanisms of regulation of the expression and function of G protein-coupled recep- tor kinases 显示文摘 | Penela P Ribas C Mayor F Jr | 2003 | Cell Signal2003,15,11: | 1 |
| 11 | Gout - associated uric acid crystals activate the NALP3 inflammasome 显示文摘 | Martinon F Petrilli V Mayor A | 2006 | Nature2006,440,: | 1 |
| 12 | The impact of European climate change regulations on international tourist markets显示文摘 | Mayor K Tol R S J | 2010 | Transportation Research Part D' Transport and Environment2010,15,1: | 1 |
| 13 | 研究发现睡前服用降压药相比晨起服药降低近半数心血管死亡显示文摘一项在全科门诊开展的纳入近2000名高血压患者的研究显示,睡前服用降压药相比晨起服药,与改善血压控制、降低近半数心血管死亡和心血管事件的发生有关、“现行的高血压治疗指南并没有提及或推荐任何首选的治疗时间”,本研究的第一作者,西班牙比戈大学(University of Vigo in Spain)生物工程和事件生物学实验室主任Ramon Hermida如是说,“晨起服药是医生推荐给患者的最常见服药方式,这一理论是基于对晨起服药会降低晨起血压水平的误解。” | Susan Mayor 祁祯楠(译) 周国鹏(校) | 2020 | 英国医学杂志中文版2020,23,4: | 1 |
| 14 | Small bowel obstruction caused by secondary tumors显示文摘 | Idelevich E Kashtan H Mayor E Brenner B | 2006 | Surg Oncol2006,15,1: | 1 |
| 15 | A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules显示文摘 | Rajagopal D Bal V Mayor S George A Rath S | 2006 | Eur J Immunol2006,36,4: | 1 |
| 16 | Analysis of poly-ubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets显示文摘 | Mayor T Russell-Lipford J Graumann J | 2005 | Mol Cell Proteomics2005,4,: | 1 |
| 17 | The Colo- rado thyroid disease prevalence study 显示文摘 | CANARIS G J MANOWITZ N R MAYOR G | 2000 | Arch Intern Med2000,160,: | 1 |
| 18 | Proteomic characterization of the human eentrosome by protein correla- tion profiling显示文摘 | Andersen J S Wilkinson C J Mayor T | 2003 | Nature2003,426,6966: | 1 |
| 19 | The Colorado thyroid dis- ease prevalence study 显示文摘 | Canaris GJ Manowitz NR Mayor G | 2000 | Arch Intern Med2000,160,4: | 1 |
| 20 | Modifications to the surface chemistry of low-rank coal-based carbon catalysts to improve flue gas nitric oxide removal显示文摘 | Izquierdo M T Rubio B Mayoral C | 2001 | Applied Catalysis B: Environmental2001,33,4: | 1 |