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| 1 | Tumor-infiltrating lymphocytes in the immunotherapy era显示文摘The clinical success of cancer immune checkpoint blockade(ICB)has refocused attention on tumor-infiltrating lymphocytes(TILs)across cancer types.The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell,NK cell,and more recently,B cell responses within the tumor microenvironment.State-of-the-art single-cell analysis of TIL gene expression profiles and clonality has revealed a remarkable degree of cellular heterogeneity and distinct patterns of immune activation and exhaustion.Many of these states are conserved across tumor types,in line with the broad responses observed clinically.Despite this homology,not all cancer types with similar TIL landscapes respond similarly to immunotherapy,highlighting the complexity of the underlying tumor-immune interactions.This observation is further confounded by the strong prognostic benefit of TILs observed for tumor types that have so far respond poorly to immunotherapy.Thus,while a holistic view of lymphocyte infiltration and dysfunction on a single-cell level is emerging,the search for response and prognostic biomarkers is just beginning.Within this review,we discuss recent advances in the understanding of TIL biology,their prognostic benefit,and their predictive value for therapy. | Sterre T.Paijens Annege Vledder Marco de Bruyn Hans W.Nijman | 2021 | Cellular & Molecular Immunology2021，18，4： | 37 |
| 2 | The risks of epilepsy after traumatic brain injury显示文摘 | Annegers JF Coan SP | 2000 | Seizure2000，9，7： | 1 |
| 3 | United States perspective on definitions and classifications显示文摘 | Annegers IF | 1997 | Epilepsia1997，，： | 1 |
| 4 | The risk of unprovoked seizures after,encephalitis and meningitis显示文摘 | Annegers JF Hauser WA Beghi E | 1988 | Neurology1988，38，9： | 1 |
| 5 | The risks of epilepsy after traumatic brain injury 显示文摘 | Annegers JF Coan SP | 2000 | Seizure2000，9，7： | 1 |
| 6 | Population based study of seizure disorder after cerebral infarction 显示文摘 | So EL Annegers JF auser WA t al | 1996 | Neurology1996，46，： | 1 |
| 7 | A population-based study of seizures after traumatic brain injuries显示文摘 | Annegers JF Hauser WA Coan SP | 1998 | N Engl J Med1998，338，： | 1 |
| 8 | Sudden unexplained death in epilepsy: observations from a large clinical development program显示文摘 | Leestma JE Annegers JF Brodie MJ | 1997 | Epilepsia1997，38，： | 1 |
| 9 | Population - based study of seizure disorder after cerebral infarction 显示文摘 | So EL Annegers JF Hauser WA | 1996 | Neurology1996，46，2： | 1 |
| 10 | The incidence,causes,and secular trends of head trauma in Olmsted County,Minnesota,1935~1974显示文摘 | Annegers JF Grabow JD Kurland LT | 1980 | Neurology1980，30，： | 1 |
| 11 | Seizures after head trauma:a population study显示文摘 | Annegers JF Groover RV | 1980 | Neurology1980，30，71： | 1 |
| 12 | Epidemiology and genetics of epilepsy显示文摘 | | 1994 | Clin1994，12，： | 1 |
| 13 | A population-based study of seizures after traumatic brain injuries显示文摘 | Annegers JF Hauser WA Coan SP | 1998 | N Engl J Med1998，338，1： | 1 |
| 14 | Prevalence of epilepsy in Rochester,Minnesota:1940-1980显示文摘 | Hauser WA Anneger JF Kurland IT | 1991 | Epilepsia1991，32，： | 1 |
| 15 | Prevalence of epilepsy in Rochester, Minnesota: 1940-1980 显示文摘 | Hauser WA Annegers JF Kurland LT | 1991 | Epilepsia1991，32，： | 1 |
| 16 | Major depression is a risk factor for seizures in older adults显示文摘 | Hesdorffer DC Hauser WA Annegers JF | | 0，，02： | 1 |
| 17 | Incidence of acute symptomatic seizures in Rochester, Minnesota, 1935-1984显示文摘 | Annegers JF Hauser WA Lee JR | 1995 | Epilepsia1995，36，： | 1 |
| 18 | United States perspective on definitions and classifications显示文摘 | Annegers JF | 1997 | Epilepsia1997，38，11： | 1 |
| 19 | Incidence of premature ovarian failure 显示文摘 | Coulam CB Adamson SC Annegers JF | 1986 | Obstet Gynecol1986，67，4： | 1 |
| 20 | Seizure recurrence after a 1st unprovoked seizure An extended following-up显示文摘 | Hauser WA Rich SS Annegers JF | 1990 | Neurology1990，40，8： | 1 |
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