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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 3 | Cytoplasmic m6A reader YTHDF3 promotes mRNA translation显示文摘 | Ang Li Yu-Sheng Chen Xiao-Li Ping Xin Yang Wen Xiao Ying Yang Hui-Ying Sun Qin Zhu Poonam Baidya Xing Wang Devi Prasad Bhattarai Yong-Liang Zhao Bao-Fa Sun Yun-Gui Yang | 2017 | Cell Research2017，27，3： | 82 |
| 4 | 5-methylcytosine promotes mRNA export--NSUN2 as the methyltransferase and ALYREF as an m5C reader显示文摘 | Yang, Xin Yang, Ying Sun, Bao-Fa Chen, Yu-Sheng Xu, Jia-Wei Lai, Wei-Yi Li, Ang Wang, Xing Bhattarai, Devi Prasad Xiao, Wen Sun, Hui-Ying Zhu, Qin Ma, Hai-Li Adhikari, Samir Sun, Min Hao, Ya-Juan Zhang, Bing Huang, Chun-Min Huang, Niu Jiang, Gui-Bin Zhao, Yong-Liang Wang, Hai-Lin Sun, Ying-Pu Yang, Yun-Gui | 2017 | Cell Research2017，27，5： | 62 |
| 5 | Ganoderic acid hinders renal fibrosis via suppressing the TGF- β/Smad and MAPK signaling pathways显示文摘Renal fibrosis is considered as the pathway of almost all kinds of chronic kidney diseases(CKD)to the end stage of renal diseases(ESRD).Ganoderic acid(GA)is a group of lanostane triterpenes isolated from Ganoderma lucidum,which has shown a variety of pharmacological activities.In this study we investigated whether GA exerted antirenal fibrosis effect in a unilateral ureteral obstruction(UUO)mouse model.After UUO surgery,the mice were treated with GA(3.125,12.5,and 50 mg·kg^−1·d^−1,ip)for 7 or 14 days.Then the mice were sacrificed for collecting blood and kidneys.We showed that GA treatment dose-dependently attenuated UUO-induced tubular injury and renal fibrosis;GA(50 mg·kg^−1·d^−1)significantly ameliorated renal disfunction during fibrosis progression.We further revealed that GA treatment inhibited the extracellular matrix(ECM)deposition in the kidney by suppressing the expression of fibronectin,mainly through hindering the over activation of TGF-β/Smad signaling.On the other hand,GA treatment significantly decreased the expression of mesenchymal cell markers alpha-smooth muscle actin(α-SMA)and vimentin,and upregulated E-cadherin expression in the kidney,suggesting the suppression of tubular epithelial-mesenchymal transition(EMT)partially via inhibiting both TGF-β/Smad and MAPK(ERK,JNK,p38)signaling pathways.The inhibitory effects of GA on TGF-β/Smad and MAPK signaling pathways were confirmed in TGF-β1-stimulated HK-2 cell model.GA-A,a GA monomer,was identified as a potent inhibitor on renal fibrosis in vitro.These data demonstrate that GA or GA-A might be developed as a potential therapeutic agent in the treatment of renal fibrosis. | Xiao-qiang Geng Ang Ma Jin-zhao He Liang Wang Ying-li Jia Guang-ying Shao Min Li Hong Zhou Shu-qian Lin Jian-hua Ran Bao-xue Yang | 2020 | Acta Pharmacologica Sinica2020，41，5： | 43 |
| 6 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 7 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 8 | MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronal-like cells by Schwann cell-conditioned medium显示文摘Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and identified differentially expressed microRNAs in bone marrow- derived mesenchymal stem cells induced by Schwann cell-conditioned medium, and explored targets and related pathways involved in their differentiation into neuronal-like cells. Primary bone marrow-derived mesenchymal stem cells were isolated from femoral and tibial bones, while primary Schwann cells were isolated from bilateral saphenous nerves. Bone marrow-derived mesenchymal stem cells were cultured in unconditioned (control group) and Schwann cell-conditioned medium (bone marrow-derived mesenchymal stem cell + Schwann cell group). Neuronal differentiation of bone marrow-derived mesenchymal stem cells induced by Schwann cell-conditioned medium was observed by time-lapse imaging. Upon induction, the morphology of bone marrow-derived mesencaymal stem cells changed into a neural shape with neurites. Results of quantitative reverse transcription-polymerase chain reaction revealed that nestin mRNA expression was upregulated from 1 to 3 days and downregulated from 3 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. Compared with the control group, microtubule-associated protein 2 mRNA expression gradually increased from 1 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. After 7 days of induction, microRNA analysis iden:ified 83 significantly differentially expressed microRNAs between the two groups. Gene Ontology analysis indicated enrichment of microRNA target genes for neuronal projection development, regulation of axonogenesis, and positive regulation of cell proliferation. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that Hippo, Wnt, transforming growth factor-beta, and Hedgehog signaling pathv/ays were potentially associated with neural differentiation of bone marrow-derived mesenchymal stem cells. This study, which carried out successful microRNA analysis of neuronal-like cells differentiated from bone marrow-derived mesenchymal stem cells by Schwann cell induction, revealed key microRNAs and pathways involved in neural differentiation of bone marrow-derived mesenchymal stem cells. All protocols were approved by the Animal Ethics Committee of Institute of Radiation Medicine, Chinese Academy of Medical Sciences on March 12, 2017 (approval number: DWLI-20170311). | Zhi-Jian Wei Bao-You Fan Yang Liu Han Ding Hao-Shuai Tang Da-Yu Pan Jia-Xiao Shi Peng-Yuan Zheng Hong-Yu Shi Heng Wu Ang Li Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，8： | 13 |
| 9 | Vision navigation for aircrafts based on 3D reconstruction from real-time image sequences显示文摘In this paper,we propose a novel vision navigation method based on three-dimensional(3D)reconstruction from real-time image sequences.It adapts 3D reconstruction and terrain matching to establish the correspondence between image points and3D space points and the terrain reference(by using a digital elevation map(DEM)).An adaptive weighted orthogonal iterative pose estimation method is employed to calculate the position and attitude angle of the aircraft.Synthesized and real experiments show that the proposed method is capable of providing accurate navigation parameters for a long-endurance flight without using a global positioning system or an inertial navigation system(INS).Moreover,it can be combined with an INS to achieve an improved navigation result. | ZHU ZunShang SU Ang LIU HaiBo SHANG Yang YU QiFeng | 2015 | Science China(Technological Sciences)2015，58，7： | 8 |
| 10 | Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma显示文摘Sulforaphane(SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN inducing autophagy in cancers are still obscure, especially in esophageal squamous cell carcinoma(ESCC), one of malignancies with high incidence in North China. Here, we mainly explored the potential function of autophagy upon SFN treatment in ESCC and molecular mechanism. We demonstrated that SFN could inhibit cell proliferation and induce apoptosis by activating caspase pathway. Moreover, we found activation of NRF2 pathway by SFN was responsible for the induction of autophagy and also a disadvantage element to the anti-tumor effects of SFN on ESCC, indicating that SFN might induce protective autophagy in ESCC. We, therefore,investigated effects of autophagy inhibition on sensitivity of ESCC cells to SFN and found that chloroquine(CQ) could neutralize the activation of SFN on NRF2 and enhance the activation of SFN on caspase pathway, thus improved the anti-tumor efficiency of SFN on ESCC in vitro and in vivo. Our study provides a preclinical rationale for development of SFN and its analogs to the future treatment of ESCC. | Zhaoming Lu Yandan Ren Li Yang Ang Jia Yi Hu Yu Zhao Wuduo Zhao Bin Yu Wen Zhao Jianying Zhang Guiqin Hou | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 11 | Long-term observations of tropospheric NO_2, SO_2 and HCHO by MAX-DOAS in Yangtze River Delta area, China显示文摘Yangtze River Delta(YRD) area is one of the important economic zones in China. However,this area faces increasing environmental problems. In this study, we use ground-based multi-axis differential optical absorption spectroscopy(MAX-DOAS) network in Eastern China to retrieve variations of NO_2, SO_2, and formaldehyde(HCHO) in the YRD area. Three cities of YRD(Hefei, Nanjing, and Shanghai) were selected for long-term observations. This paper presents technical performance and characteristics of instruments, their distribution in YRD, and results of vertical column densities(VCDs) and profiles of NO_2, SO_2, and HCHO.Average diurnal variations of tropospheric NO_2 and SO_2 in different seasons over the three stations yielded minimum values at noon or in the early afternoon, whereas tropospheric HCHO reached the maximum during midday hours. Slight reduction of the pollutants in weekends occurred in all the three sites. In general trace gas concentrations gradually reduced from Shanghai to Hefei. Tropospheric VCDs of NO_2, SO_2, and HCHO were compared with those from Ozone Monitoring Instrument(OMI) satellite observations, resulting in R^2 of 0.606, 0.5432, and 0.5566, respectively. According to analysis of regional transports of pollutants, pollution process happened in YRD under the north wind with the pollution dissipating in the southeast wind. The feature is significant in exploring transport of tropospheric trace gas pollution in YRD, and provides basis for satellite and model validation. | Xin Tian Pinhua Xie Jin Xu Ang Li Yang Wang Min Qin Zhaokun Hu | 2018 | Journal of Environmental Sciences2018，30，9： | 7 |
| 12 | Geomorphological Evolution Revealed by Aeolian Sedimentary Structure in Badain Jaran Desert on Alxa Plateau, Northwest China显示文摘The Badain Jaran Desert,located in the Alxa Plateau,Northwest China,features mega-dunes and a unique dune-lake alternation landscape.This paper presented the aeolian sediment structures of three representative dunes in the Badain Jaran Desert using ground-penetrating radar (GPR).We processed and analyzed the GPR data and investigated the feasibility of using integrated GPR and sedimentological data to reconstruct dunes structure,sedimentary environment and geomorphological evolution.The results show that the internal structures of star dune and transverse dune represent various stages of mega-dune evolution: the main deposition processes of mega-dune are similar to those of transverse dunes but have a more complicated mechanism of sand transport and deposition because of the superimposition of dunes;the upper section of the mega-dune has a structure similar to that of star dune,with vertical aggradations on top.Diffraction hyperbolae in the GPR profile indicates that the presence of ancient dunes characterized by calcareous cementation layers is involved in the maintenance of mega-dunes,and water levels,shown by continuous,sub-horizontal GPR reflections,are supposed to be closely related to mega-dunes and the interdune lakes.Outcrop of wet sand and horizontal stratifications on the GPR image indicate moisture potentials with different levels inside mega-dunes.The multiplex geomorphology in the Badain Jaran Desert is the result of global climatic undulation,the unique geographical location,the geological structural features,etc. | BAI Yang WANG Nai'ang LIAO Kongtai Patrick KLENK | 2011 | Chinese Geographical Science2011，21，3： | 6 |
| 13 | Refining constitutive relation by integration of finite element simulations and Gleeble experiments显示文摘Thermo-mechanical coupled finite element calculations were carried out to simulate the Gleeble compression of the samples of a titanium alloy(Ti60), and the results are analyzed and compared with the actual compression tests conducted on a Gleeble 3800 thermo-mechanical simulator. The changes in temperature, stress and strain distribution in the samples and the source of error on the constitutive relations from Gleeble hot compression test were analyzed in detail. Both simulations and experiments showed that the temperature distribution in the specimen is not uniform during hot compression, resulting in significant deformation inhomogeneity and non-ignorable error in the flow stress strain relation,invalidating the uniform strain assumption commonly assumed when extracting the constitutive relation from Gleeble tests. Based on the finite element simulations with iterative corrections, we propose a scheme to refine the constitutive relations from Gleeble tests. | D.J. Yu D.S. Xu H. W ang Z.B. Zhao G.Z. Wei R. Yang | 2019 | Journal of Materials Science & Technology2019，35，6： | 6 |
| 14 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 15 | Analysis of the Phenotype and the Restriction Enzyme Mapping Level of Mutations Induced by the New Mutagen Glycidyl Methacrylate显示文摘Glycidyl methaerylate (GMA) is a recently recognized chemical mutagen. In order to explore the mutagenicity and mutagenic process of GMA, plasmid pBR322 was used for in vitro binding, mutant screening, and restriction enzyme mapping. The binding between GMA and DNA in vitro has been verified by means of a spectrophotometric method. When pBR322 and GMAbound pBR322 were used to transform Eschenchia coli HB101, the following results were obtained: (1) The transformation efficiency of GMA-bound pBR322 was much lower than that of pBR322 alone. (2) GMA-bound pBR322 induced phenotype changes in competent cells (i.e., tetracycline-resistance inactivation or ampicillin-resistance inactivation). There were two mutants of pBR322, Ap^RTc^S and Ap^STc^R, in the transformants and a deductive mutant Ap^STc^S in the nontranstormants. (3) All of the selected mutants were stable and heritable. (4) When restriction enzyme maps were used to analyze the mutant Ap^RTc^S, four of seven maps were changed. some sites were shifted to other resistant gene regions, for example, sites of Bgll, EcoRl, Ilindlll. Hinclll, etc., and there was a new recognition site for Hindi (252). We did not observe any DNA fragment insertion or deletion on any maps. Our results suggest that when GMA is covalently linked to the plasmid DNA, it gives rise to a premutagenic lesion of DNA that is converted in vivo into a point mutation. (C)1990 Academic Press, Inc. | XIE DA-YING,~* GAO HUI-LAN,~* ZUO JIN,ZHANG WEI,~*LI ZHONG-SHENG,~*YANG HUI-FANG,~*ANG FANG FU-DE~*Institute of Occupational Medicine. Chinese Academy of Preventive Medicine, Beijing 100050, and Institute of Basic Medical Sciences. Chinese Academy of Medical Sciences, Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，2： | 5 |
| 16 | The New Synthesis of Azo Urea from Substituted Semicarbazide显示文摘Using N-bromosuccinimide and pridine as the 0xidation s}-stem to dehydrogenale anly substituted semicarbazide to form azo compounds is described for the firs1 time in this paper Nine azo conlpounds have been prepared in excellent lield under mild condition This method onle needs simple instrument and short reaction | Xiao Yang WANG Yu Lu WANG Jian Ping LI Cai ’Lan W’ANG Hong WANG (Department of Chemistry ,Henan Normal University Xinxiang 453002 ) | 1997 | Chinese Chemical Letters1997，8，6： | 5 |
| 17 | Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor显示文摘Chemotherapy-related fatigue(CRF)is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy,which not only largely reduces the quality of life in patients,but also diminishes their physical and social function.At present,there is no effective drug for preventing and treating CRF.Ganoderic acid(GA),isolated from traditional Chinese medicine Ganoderma lucidum,has shown a variety of pharmacological activities such as anti-tumor,anti-inflammation,immunoregulation,etc.In this study,we investigated whether GA possessed anti-fatigue activity against CRF.CT26 tumor-bearing mice were treated with 5-fluorouracil(5-FU,30 mg/kg)and GA(50 mg/kg)alone or in combination for 18 days.Peripheral and central fatigue-related behaviors,energy metabolism and inflammatory factors were assessed.We demonstrated that co-administration of GA ameliorated 5-FU-induced peripheral muscle fatigue-like behavior via improving muscle quality and mitochondria function,increasing glycogen content and ATP production,reducing lactic acid content and LDH activity,and inhibiting p-AMPK,IL-6 and TNF-αexpression in skeletal muscle.Co-administration of GA also retarded the 5-FU-induced central fatigue-like behavior accompanied by down-regulating the expression of IL-6,iNOS and COX2 in the hippocampus through inhibiting TLR4/Myd88/NF-κB pathway.These results suggest that GA could attenuate 5-FU-induced peripheral and central fatigue in tumor-bearing mice,which provides evidence for GA as a potential drug for treatment of CRF in clinic. | Abudumijiti Abulizi Ling Hu Ang Ma Fang-yu Shao Hui-ze Zhu Si-mei Lin Guang-ying Shao Yue Xu Jian-hua Ran Jing Li Hong Zhou Dong-mei Lin Lian-fu Wang Min Li Bao-xue Yang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 5 |
| 18 | Mechanisms of antiprostate cancer by gum mastic:NF-κB signal as target显示文摘瞄准:学习口香糖乳香的效果,自然树脂,在 proliferationof 上雄激素无关的前列腺癌症 PC-3 房间,并且进一步调查机制 involvedin 这个规章的系统,拿原子因素 kappa B ( NF-kappa B )target.Methods:3-( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyltetrazohum 溴化物( MTT )试金和流动 cytometer wereused 被执行在 PC-3 cells.Then ,记者 geneassay , RT-PCR ,并且西方的弄污的增长上检测口香糖乳香的效果到的信号 Gummastic 禁止了 PC-3 房间生长并且在 cyclin Dl ,关键房间 cycleregulator 和NF-的 PC-3 cells.The 表示在 G1 phase.Gum 乳香 alsosuppressed NF- kappa B 活动堵住了 PC-3 房间周期 kappa B 下游的目标基因,作为 well.Moreover 被减少,口香糖 masticdecreased p-AKT 蛋白质水平并且增加了 I kappaB alpha 蛋白质 level.Conclusion :Gummastic 禁止了增长并且在 PC-3 房间 bysuppressing NF- kappa B 活动和 NF- kappa B 信号堵住了房间周期前进小径。 | Mei-lan HE Ang LI Chun-su XU Shun-li WANG Meng-jie ZHANG Hua GU Yao-qin YANG Hui-hong TAO | 2007 | Acta Pharmacologica Sinica2007，28，3： | 5 |
| 19 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 20 | Clinical significance of HBME-1,Galectin-3,and CK19 expression and the status of BRAF mutation in papillary thyroid carcinoma显示文摘Objective The aim of this study was to explore the clinical significance of the expression of proteins human bone marrow endothelial cell markers(HBME-1), Galectin-3, and cytokeratin19(CK19), as well as the status of v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation in papillary thyroid carcinoma(PTC). Methods Immunohistochemical staining was performed in 82 specimens each of PTC and papillary benign lesions to detect the expression of HBME-1, Galectin-3, and CK19. Polymerase chain reaction(PCR) and gene sequencing were performed on 60 specimens each of PTC and papillary benign lesions to detect the status of BRAF mutation. Results The positive expression ratios of HBME-1, Galectin-3, and CK19 in PTC were 98.8%, 97.6% and 100% respectively, which were significantly higher than the expressions in papillary benign lesions(P < 0.05). No significant relationship was observed between the expression of these makers and the clinicopathological features of PTC. The sensitivity of co-expression of HBME-1 and CK19 or HBME-1 and Galectin-3 as diagnostic criteria of PTC was 99.9%, with a specificity of 95.4%. BRAF mutation was detected in 40 of 60 PTC(66.7%) specimens. There was a statistical difference in BRAF mutations between PTC and papillary benign lesions(P < 0.05); there were no associations between BRAF mutation and the clinicopathological features of PTC. Conclusion Combined immunohistochemical staining of HBME-1, Galectin-3, and CK19 can further improve the sensitivity and specificity of differential diagnosis of PTC. BRAF mutation is a significant genetic event, which may have diagnostic value for PTC. | Li Zheng Min Zhao Xiangyang Hu Jin Huang Ling Ang Hongguang Hu Qiang Zou Jin Wang Mingqiang Liu Yang Zhao | 2016 | Oncology and Translational Medicine2016，2，4： | 4 |
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