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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Microvascular free tissue transfer in elderly patients the Toronto experience 显示文摘 | Beausang ES Ang EE Lipa JE | 2003 | Head Neck2003，25，： | 1 |
| 3 | MR renography using a dynamic gradient-echo sequence and low-dose gadopentetate dimeglumine as an alternative to radionuclide renegraphy显示文摘 | Hui Seong The Ee Sin Ang Weng Cheong Wong | 2003 | AJR2003，181，： | 1 |
| 4 | Biology and action of colony--stimulating factor-1显示文摘 | Stanley E R B erg K L E instein D B L ee P S Pixley F J W ang Y Yeung YG | | 0，，： | 1 |
| 5 | Microvascular free tissue transfer in elderly patients:the Toronto experience显示文摘 | Beausang ES Ang EE Lipa J | | 0，，7： | 1 |
| 6 | 甲状腺相关性眼病伴眼外肌肌腱受累1例(英文)显示文摘目的:报告1例甲状腺相关性眼病的非典型CT扫描表现。方法:一位64岁的中国女性出现复视3mo,无视力模糊。14a前她曾患甲状腺功能亢进症伴多结节甲状腺肿并行甲状腺切除术。眼科检查发现双眼下斜视并向上注视受限。左眼red desaturation并Ⅰ级相对性瞳孔传入障碍。T3,T4和促甲状腺激素(thyroid stimulating hormone,TSH)正常。TSH受体、抗体水平高,与Graves'病一致。磁共振成像(magnetic resonance imaging,MRI)显示双下直肌弥漫性增大,肌腱受累。结果:给予几周期静脉注射甲基强的松龙继之以口服强的松后视力无提高,反之继续下降。行左眼眼眶减压术,术后其左眼视力有所改善。结论:有肌腱受累的眼外肌增大不能排除甲状腺相关性眼眶病(thyroid assciated orbitopathy,TAO)的可能。 | Ng Guan Fook Dinesh Kumar Ang Ee Ling Liza-Sharmini AT | 2012 | 国际眼科杂志2012，12，3： | 1 |
| 7 | Microvascular free tissue transfer in elderly patients the Toronto experience显示文摘 | Beausang ES Ang EE Lipa JE | 2003 | Head Neck2003，25，7： | 1 |
| 8 | A step through the looking glass显示文摘Despite our many advances in deconstructing and understanding cellular and biomolecular machineries,the homochirality of life remains an enigma.Since our earliest ancestors,the central dogma has operated solely on | Youyun Liang Ee Lui Ang Huimin Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 0 |
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