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| 1 | Exosomal microRNAs as a potential therapeutic strategy in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the fifth most com-mon cancer and the second cause of cancer-related death worldwide. The incidence of HCC is constantly increasing in correlation with the rise in diabetes and obesity, arguing for an urgent need for new developments in the treatment of this lethal cancer. Exosomes are small double-membrane vesicles loaded with distinct cargos, particularly small non-coding RNAs called microRNAs, representative of each donor cell and secreted to affect the features of neighboring cells or recipient cells located further away, like in the case of metastasis. A better understanding of the role of exosomes with a microRNA signature in cancer pathogenesis gave rise to the concept of their use as a noninvasive diagnostic biomarker and in the treatment of cancer, including HCC. In this communication, we review recent works that demonstrate that hepatic stellate cells establish an epigenetic communication with liver cancer cells, which affects their pro-malignant features. If naturally secreted patient-derived exosomes show major limitations concerning their clinical use, bio-engineered exosome mimetics that incorporate controlled components and exhibit no protumoral properties could be promising carriers for the treatment of liver cancers, which is the organ preferentially targeted by systemic injection of exosomes. | Angélique Gougelet | 2018 | World Journal of Hepatology2018，10，11： | 6 |
| 2 | Gene induction during differentiation of human monocytes into dendritic cells:an integrated study at the RNA and protein levels 显示文摘 | Catherine Angénieux | 2001 | Funct Integr Genomics2001，1，： | 1 |
| 3 | Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients显示文摘Background:New treatments are needed to reduce the risk of progression of coronavirus disease 2019(Covid-19).Molnupiravir is an oral,small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods:We conducted a phase 3,double-blind,randomized,placebo-controlled trial to evaluate the efficacy and safety of treatment with molnupiravir started within 5 days after the onset of signs or symptoms in nonhospitalized,unvaccinated adults with mild-to-moderate,laboratory-confirmed Covid-19 and at least one risk factor for severe Covid-19 illness.Participants in the trial were randomly assigned to receive 800 mg of molnupiravir or placebo twice daily for 5 days.The primary efficacy end point was the incidence hospitalization or death at day 29;the incidence of adverse events was the primary safety end point.A planned interim analysis was performed when 50%of 1550 participants(target enrollment)had been followed through day 29. | Angélica Jayk Bernal | 2021 | 四川生理科学杂志2021，43，10： | 0 |
| 4 | A Review of Cuban Ophiolites: Structure and Tectonic Setting显示文摘The Cuban Jurassic-Cretaceous ophiolite-related rocks crop out to the north of the island,along the so-called'northern ophiolite belt',one of the largest(>1000 km in length)ophiolitic belts in the Caribbean.This belt is part of the Cuban fold belt,a tectonic unit made up of deformed and metamorphosed nappes accreted to the North America/ | Angélica Isabel Llanes-Castro | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 0 |
| 5 | MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation显示文摘A recent work of Iliopoulos et al published in Cell highlighted a circuit orchestrated by microRNAs (miRNAs) that results in liver tumorigenesis and inflammation. This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. These promising data support the use of miRNA mimics or inhibitors as potent therapeutic approaches in liver cancer. | Angélique Gougelet Sabine Colnot | 2013 | World Journal of Gastroenterology2013，19，4： | 2 |
| 6 | Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate显示文摘 | Canola K Angénieux B Tekaya M | | 0，，01： | 1 |
| 7 | CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling显示文摘 | Angélique Levoye Karl Balabanian | 2009 | Blood2009，113，： | 1 |
| 8 | Intravenous immunoglobulin modulates lymphocyte CD54 and monocyte FcγRII expression in patients with chronic inflammatory neuropathies显示文摘 | A Créange N.A Gregson R.A.C Hughes | 2002 | Journal of Neuroimmunology2002，，1： | 1 |
| 9 | New Insights into Nitric Oxide Signaling in Plants显示文摘 | Angélique Besson-Bard Alain Pugin David Wendehenne | 2008 | Annual Review of Plant Biology2008，，： | 1 |
| 10 | CT-based delineation of lymph node levels and related CTVs in the node-negative neck:DAHANCA,EORTC,GORTEC,NCIC,RTOG consensus guidelines显示文摘 | Grégoire V Levendag P Ang KK | | 0，，3： | 1 |
| 11 | Using new optical materials and DOE in low-cost lenses for uncooled IR cameras显示文摘 | Bacchus J M Angénieux T | | 0，，： | 1 |
| 12 | A comparative study on the uptake and translocation of organochlorines by Phragmites australis显示文摘 | Angélique San Miguel Patrick Ravanel Muriel Raveton | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 13 | Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate显示文摘 | Canola K Angénieux B Tekaya M | | 0，，： | 1 |
| 14 | Non-oxygenic Photosynthesis in the Sulphurous Lake Cisó,North-eastern Spain显示文摘1 Introduction Situated in the Iberian Peninsula,Lake Cisóis a sulphide-rich lake that belongs to the Ba?oles karstic system in Girona,north-eastern part of Spain.Lake Cisóis holomictic,and covers a small area of around 650 m2 | Angélica ANGLS LI Yiliang | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 15 | Absorption, metabolism, and excretion of green tea flavan‐3‐ols in humans with an ileostomy显示文摘 | AngéliqueStalmach WilliamMullen HeikeSteiling GaryWilliamson Michael E. J.Lean AlanCrozier | 2010 | Mol Nutr Food Res2010，，3： | 2 |
| 16 | Lead Bioaccessibility in Soil and Mine Wastes After Immobilization with Phosphate显示文摘 | Sérgio T. Bosso Jacinta Enzweiler R?mulo S. Angélica | 2008 | Water, Air, and Soil Pollution . 2008 (1-4)2008，，： | 1 |
| 17 | Novel applications of red mud as coagulant,adsorbent and catalyst for environmentally benign processes显示文摘 | Wang X B Ang H M TadéM O | 2008 | Chemosphere2008，72，11： | 1 |
| 18 | CT-based delineation of lymph node levels and related CTVs in the node-negative neck:DAHANCA,EORTC,GORTEC,NCIC,RTOG consensus guidelines 显示文摘 | Grégoire V Levendag P Ang KK | 2003 | Radiother Oncol2003，69，3： | 1 |
| 19 | A proposal for a set of attributes relevant for Web portal data quality显示文摘 | Angélica Caro Coral Calero Ismael Caballero Mario Piattini | 2008 | Software Quality Journal2008，，4： | 1 |
| 20 | Esterification of Oleic Acid over Solid Acid Catalysts Prepared from Amazon Flint Kaolin显示文摘 | Nascimento L S D L M Z Tito Angélica R S | 2011 | Appl Catal B2011，101，： | 1 |
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