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| 1 | A study of morphing aircraft on morphing rules along trajectory显示文摘Morphing aircraft can meet requirements of multi-mission during the whole flight due to changing the aerodynamic shape,so it is necessary to study itsmorphing rules along the trajectory.However,trajectory planning considering morphing variables requires a huge number of expensive CFD computations due to the morphing in view of aerodynamic performance.Under the given missions and trajectory,to alleviate computational cost and improve trajectory-planning efficiency formorphing aircraft,an offline optimizationmethod is proposed based onMulti-Fidelity Kriging(MFK)modeling.The angle of attack,Mach number,sweep angle and axial position of the morphing wing are defined as variables for generating training data for building the MFK models,in which many inviscid aerodynamic solutions are used as low-fidelity data,while the less high-fidelity data are obtained by solving viscous flow.Then the built MFK models of the lift,drag and pressure centre at the different angles of attack andMach numbers are used to predict the aerodynamic performance of the morphing aircraft,which keeps the optimal sweep angle and axial position of the wing during trajectory planning.Hence,themorphing rules can be correspondingly acquired along the trajectory,aswell as keep the aircraftwith the best aerodynamic performance during thewhole task.The trajectory planning of amorphing aircraft was performed with the optimal aerodynamic performance based on the MFK models,built by only using 240 low-fidelity data and 110 high-fidelity data.The results indicate that a complex trajectory can take advantage of morphing rules in keeping good aerodynamic performance,and the proposed method is more efficient than trajectory optimization by reducing 86%of the computing time. | Xiaoyu CHEN Chunna LI Chunlin GONG Liangxian GU Andrea Da RONCH | 2021 | Chinese Journal of Aeronautics2021，34，7： | 8 |
| 2 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | A modified airfoil-based piezoaeroelastic energy harvester with double plunge degrees of freedom显示文摘In this letter,a piezoaeroelastic energy harvester based on an airfoil with double plunge degrees of freedom is proposed to additionally take advantage of the vibrational energy of the airfoil pitch motion.An analytical model of the proposed energy harvesting system is built and compared with an equivalent model using the well-explored pitch-plunge configuration.The dynamic response and average power output of the harvester are numerically studied as the flow velocity exceeds the cut-in speed(flutter speed).It is found that the harvester with double-plunge configuration generates 4%–10% more power with varying flow velocities while reducing 6% of the cut-in speed than its counterpart. | Yining Wu Daochun Li Jinwu Xiang Andrea Da Ronch | 2016 | Theoretical & Applied Mechanics Letters2016，6，5： | 2 |
| 4 | Extension of analytical indicial aerodynamics to generic trapezoidal wings in subsonic flow显示文摘Analytical indicial aerodynamic functions are calculated for several trapezoidal wings in subsonic flow, with a Mach number 0.3 Ma 0.7. The formulation herein proposed extends wellknown aerodynamic theories, which are limited to thin aerofoils in incompressible flow, to generic trapezoidal wing planforms. Firstly, a thorough study is executed to assess the accuracy and limitation of analytical predictions, using unsteady results from two state-of-the-art computational fluid dynamics solvers as cross-validated benchmarks. Indicial functions are calculated for a step change in the angle of attack and for a sharp-edge gust, each for four wing configurations and three Mach numbers. Then, analytical and computational indicial responses are used to predict dynamic derivatives and the maximum lift coefficient following an encounter with a one-minus-cosine gust. It is found that the analytical results are in excellent agreement with the computational results for all test cases. In particular, the deviation of the analytical results from the computational results is within the scatter or uncertainty in the data arising from using two computational fluid dynamics solvers. This indicates the usefulness of the developed analytical theories. | Andrea DA RONCH Antonino VENTURA Marcello RIGHI Matteo FRANCIOLINI Marco BERCI Daniel KHARLAMOV | 2018 | Chinese Journal of Aeronautics2018，31，4： | 2 |
| 5 | Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode[Invited]显示文摘A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation(QAM) signals at 16 GBd is demonstrated with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence(≤0.5 dB) and the high conversion efficiency(CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due to the reverse-biased p-i-n diode are key in ensuring high CE levels. | FRANCESCO DA Ros ANDRZEJ GAJDA ERIK LIEBIG EDSON P.DA SILVA ANNA PECZEK PETER D.GIROUARD ANDREAS MAI KLAUS PETERMANN LARS ZIMMERMANN MICHAEL GALILI LEIF K.OXENLOWE | 2018 | Photonics Research2018，6，5： | 1 |
| 6 | 基于非线性涡格法的快速静气动弹性数值模拟技术显示文摘基于2.5D RANS数据和VLM耦合的方式,发展了一种考虑非线性流动效应的混合型涡格法HVLM.采用矩形直/后掠机翼两个外形的跨声速算例,通过与VLM、三维CFD计算数据的比较,对HVLM的气动力预测精度进行了分析与评估.对比结果表明,HVLM在大幅降低时间成本的前提下可以获得和三维CFD方法预测值十分接近的计算数据,对线化VLM方法的修正效果显著.然后,HVLM与悬臂梁有限元求解耦合,实现了一种面向三维机翼的快速静气动弹性数值模拟技术,并通过矩形直机翼算例进行了验证.耦合算例的时间分析数据表明,HVLM/Beam耦合的方式能够在10 s以内完成1次三维机翼静气动弹性分析,在气动/结构耦合分析、优化设计方面展示出了良好的应用前景. | 孙岩 Andrea Da Ronch 王运涛 孟德虹 洪俊武 许贤超 | 2020 | 气体物理2020，5，6： | 1 |
| 7 | 2-aminoethyl Dihydrogen Phosphate as a Modulator of Proliferative and Apoptotic Effects in Breast Cancer Cell Lines显示文摘Background: Breast cancer is a type of cancer that affects more women throughout the world, in developing anddeveloped countries. 2-AEH2P is a phospholipid analog of cellular membrane, which makes it different from existing molecules fortheir absorption, stability and display anti-inflammatory, anti-proliferative and pro-apoptotic properties. Methods: MCF-7 humanbreast adenocarcinoma cells were treated with 2-AEH2P. The viability and adhesion cells were evaluated by MTT assay. Cell cyclephases, apoptosis, markers and mitochondrial potential were assessed by flow cytometry. Morphological ultrastructural analyzeswere performed by laser confocal microscopy. Results: MCF-7 Tumor cells acquired round shapes, lost cytoplasmic expansions,formed clusters in suspension and decreased significantly viability. There were changes in the morphology, membrane fragmentationand loss of cytoplasmic projection. The obtained concentrations for IC50% were 37.2;25.8;1.8 mM for periods of 24, 48 and 72 h,respectively. Changes in the distribution of cell population phases of the cell cycle showed an increase in fragmented DNA and anincrease in the G2/M phase. The expression β-gal showed proliferative reduction induced by 2-AEH2P. Laser confocal microscopyshowed changes in the mitochondrial membrane and alteration in distribution. Proliferative index of MCF-7 tumor cells treated with2-AEH2P decreased significantly when compared to fibroblast normal cells. The compound 2-AEH2P is a phospholipid withantiproliferative potential and apoptosis modulator. | Manuela Garcia Laveli da Silva Laertty Garcia de Sousa Cabral Monique Gonçalves Alves Thais deOliveira Conceição Henrique Hesse Rosa Andrea Nogueira Laiso Daniel da Conceição Rabelo Durvanei Augusto Maria | 2021 | Journal of Pharmacy and Pharmacology2021，9，3： | 1 |
| 8 | Stable NiO-CeO_(2) nanoparticles with improved carbon resistance for methane dry reforming显示文摘High surface area mixed oxide 8.7%NiO-CeO_(2) nanoparticles(122 m2/g;6-7 nm)were prepared using a reversed microemulsion method,and were tested for dry methane reforming(DRM).The catalytic activity of these nanoparticles remains stable under the severe conditions of DRM(700℃),and they show better carbon resistance than conventional NiO-CeO_(2) catalysts prepared without control of the size.The activity and selectivity of nanoparticles and reference catalyst are similar,but nanoparticles reduce the accumulation of carbon by 63%during the DRM tests,which is a key feature for this reaction.XPS and H_(2)-TPR suggest that the improved carbon resistance of the nanoparticles is due to the better interaction and cooperation between NiO and CeO_(2) mixed phases.In nanoparticles,the participation of cerium cations in the redox processes taking place during DRM stabilizes cationic species of nickel.On the contrary,the catalyst prepared without control of the size suffers segregation of Ni during DRM reaction,and segregated Ni explains the higher catalytic formation of carbon. | Andrea Cárdenas-Arenas Esther Bailón-García Dolores Lozano-Castelló Patrick Da Costa Agustín Bueno-López | 2022 | Journal of Rare Earths2022，40，1： | 1 |
| 9 | Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi显示文摘 | Ana Carolina Alves de Paula e Silva Caroline Barcelos Costa-Orlandi Fernanda Patrícia Gullo Fernanda Sangalli-Leite Haroldo Cesar de Oliveira Julhiany de Fátima da Silva Liliana Scorzoni Nayla de Souza Pitangui Suélen Andrea Rossi Tatiane Benaducci Vaness | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 10 | Chronic subclinical inflammation as part of the insulin resistance syndrome 显示文摘 | Andreas F Ralph DA George H | 2000 | Circulation2000，102，1： | 1 |
| 11 | When to Perform Bone Scan in Patients with Newly Diagnosed Prostate Cancer: External Validation of the Currently Available Guidelines and Proposal of a Novel Risk Stratification Tool 显示文摘 | Alberto Briganti Niccolò Passoni Matteo Ferrari Umberto Capitanio Nazareno Suardi Andrea Gallina Luigi Filippo Da Pozzo Maria Picchio Valerio Di Girolamo Andrea Salonia Liugi Gianolli Cristina Messa Patrizio Rigatti Francesco Montorsi | 2009 | European Urology2009，，4： | 1 |
| 12 | l_(1)-based calibration of POD-Galerkin models of two-dimensional unsteady flows显示文摘This paper discusses a physics-informed methodology aimed at reconstructing efficiently the fluid state of a system.Herein,the generation of an accurate reduced order model of twodimensional unsteady flows from data leverages on sparsity-promoting statistical learning techniques.The cornerstone of the approach is l_(1) regularised regression,resulting in sparselyconnected models where only the important quadratic interactions between modes are retained.The original dynamical behaviour is reproduced at low computational costs,as few quadratic interactions need to be evaluated.The approach has two key features.First,interactions are selected systematically as a solution of a convex optimisation problem and no a priori assumptions on the physics of the flow are required.Second,the presence of a regularisation term improves the predictive performance of the original model,generally affected by noise and poor data quality.Test cases are for two-dimensional lid-driven cavity flows,at three values of the Reynolds number for which the motion is chaotic and energy interactions are scattered across the spectrum.It is found that:(A)the sparsification generates models maintaining the original accuracy level but with a lower number of active coefficients;this becomes more pronounced for increasing Reynolds numbers suggesting that extension of these techniques to real-life flow configurations is possible;(B)sparse models maintain a good temporal stability for predictions.The methodology is ready for more complex applications without modifications of the underlying theory,and the integration into a cyberphysical model is feasible. | Riccardo RUBINI Davide LASAGNA Andrea DA RONCH | 2021 | Chinese Journal of Aeronautics2021，34，1： | 1 |
| 13 | Elevated levels of acute phase protetns and plasminogen activeator inhibitor-1 predict the development of type 2 diabetes:The Insulin Resistance Atheroscleresis Study显示文摘 | Ralph DA Russell PT | 2002 | Diabetes2002，51，： | 1 |
| 14 | A Randomized, Multicenter, Single-Blinded Trial Comparing Paclitaxel-Coated Balloon Angioplasty With Plain Balloon Angioplasty in Drug-Eluting Stent Restenosis显示文摘 | Harald Rittger Johannes Brachmann Anil-M. Sinha Matthias Waliszewski Marc Ohlow Andreas Brugger Holger Thiele Ralf Birkemeyer Volkhard Kurowski Ole-A. Breithardt Martin Schmidt Stefan Zimmermann Sandra Lonke Moritz von Cranach The-Vinh Nguyen Werner G. Da | 2012 | Journal of the American College of Cardiology2012，，15： | 1 |
| 15 | Mutations in MERTK,the human orthologue of the RS rat retinal dystrophy gene,cause retinitis pigmentosa显示文摘 | Andreas G Li Y Thompson DA | 2000 | Nature genet2000，26，： | 1 |
| 16 | An Ontology - based Method for User Model Acquisition 显示文摘 | Celia da Costa Pereira Andrea G B Tettamanzi | 2006 | Soft Computing in Ontologies and Semantic Web2006，，204： | 1 |
| 17 | Application of plant derived compounds to control fungal spoilage and mycotoxin production in foods显示文摘 | Lucía da Cruz Cabral Virginia Fernández Pinto Andrea Patriarca | 2013 | International Journal of Food Microbiology2013，，1： | 1 |
| 18 | Elevated levels of acute phase proteins and plasminogen activeator inhibitor- 1 predict the development of type 2 diabetes:the insulin resistance atherosclerosis study显示文摘 | Andreas F Ralph DA Russell PT | 2002 | Diabetes2002，51，： | 1 |
| 19 | Proposed nomenclature for Pseudallescheria,Scedosporium and related genera显示文摘As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans. | Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes | 2014 | Fungal Diversity2014，，4： | 1 |
| 20 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
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