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| 1 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 2 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 3 | Outcome of severe encephalomyelitis in children: effect of high-dose methylprednisone and immonuglobulins显示文摘 | Shahar E Andraus J Savitzki D | 2002 | J Child Neurol2002，17，： | 1 |
| 4 | Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases: a systematic review 显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloproctol2014，18，2： | 1 |
| 5 | Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases : a systematic review 显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloprocto12014，18，2： | 1 |
| 6 | Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors显示文摘 | Lorraine C. Axford Piyush K. Agarwal Kelly H. Anderson Laura N. Andrau John Atherall Stephanie Barker James M. Bennett Michael Blair Ian Collins Lloyd G. Czaplewski David T. Davies Carlie T. Gannon Dushyant Kumar Paul Lancett Alastair Logan Christopher J. | 2013 | Bioorganic & Medicinal Chemistry Letters2013，，24： | 1 |
| 7 | The best approach for diagnosing primary sclerosing cholangitis显示文摘 | Andraus W Haddad L Nacif LS | 2011 | Clinics (Sao Paulo)2011，66，11： | 1 |
| 8 | The best approach for splenectomy in portal hypertension 显示文摘 | Andraus W Pinheiro R S Haddad L B | 2011 | Surgery2011，149，6： | 1 |
| 9 | Simulta-neous laparoscopic resection of primary colorectal cancer and asso- ciated liver metastases : a systematic review 显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloproctol2014，18，2： | 1 |
| 10 | Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases:a systematic review显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloproctol2014，18，2： | 1 |
| 11 | Primary generalized epilepsy during infancy and early childhood 显示文摘 | Shahar E Barak S Andraus J | 2004 | J Child Neurol2004，19，3： | 1 |
| 12 | S - nitroso - N - acetyl- eysteine ameliorates ischemia - reperfusion injury in the steatotic liver 显示文摘 | Andraus W Souza GF Oliveira MG | 2010 | Clinics2010，65，7： | 1 |
| 13 | Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases: a systematic review显示文摘 | R. M. Lupinacci W. Andraus L. B. Paiva Haddad L. A. Carneiro D′Albuquerque P. Herman | 2014 | Techniques in Coloproctology2014，，2： | 1 |
| 14 | Childhood-onset epileptic blindness-clinical correlates and outcomes 显示文摘 | Shahar E Ravid S Andraus J | 2004 | Harefuah2004，143，1： | 1 |
| 15 | Simultaneous laparoscopic resection of primary colorectal cancer and associated liver metastases: a systematic review 显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloproctol2014，18，： | 1 |
| 16 | The best approach for splenectomy in portal hypertension显示文摘 | Andraus W Pinheiro RS Haddad LB | 2011 | Surgery2011，149，6： | 1 |
| 17 | Sciatic her- nia mimicking perianal abscess in a cirrhotic patient显示文摘 | Andraus W Haddad L B Ferro O C | 2012 | Case Rep Med2012，2012，65： | 1 |
| 18 | Living-donor liver transplantation in Budd-Chiari syndrome with inferior vena cava complete thrombosis:A case report and review of the literature显示文摘BACKGROUND Budd-Chiari syndrome(BCS)is a challenging indication for liver transplantation(LT)due to a combination of massive liver,increased bleeding,retroperitoneal fibrosis and frequently presents with stenosis of the inferior vena cava(IVC).Occasionally,it may be totally thrombosed,increasing the complexity of the procedure,as it should also be resected.The challenge is even greater when performing living-donor LT as the graft does not contain the retrohepatic IVC;thus,it may be necessary to reconstruct it.CASE SUMMARY A 35-year-old male patient with liver cirrhosis due to BCS and hepatocellular carcinoma beyond the Milan criteria underwent living-donor LT with IVC reconstruction.It was necessary to remove the IVC as its retrohepatic portion was completely thrombosed,up to almost the right atrium.A right-lobe graft was retrieved from his sister,with outflow reconstruction including the right hepatic vein and the branches of segment V and VIII to the middle hepatic vein.Owing to massive subcutaneous collaterals in the abdominal wall,venovenous bypass was implemented before incising the skin.The right atrium was reached via a transdiaphragramatic approach.Hepatectomy was performed en bloc with the retrohepatic vena cava.It was reconstructed with an infra-hepatic vena cava graft obtained from a deceased donor.The patient remains well on outpatient clinic follow-up 25 mo after the procedure,under an anticoagulation protocol with warfarin.CONCLUSION Living-donor LT in BCS with IVC thrombosis is feasible using a meticulous surgical technique and tailored strategies. | Vinicius Rocha-Santos Daniel Reis Waisberg Rafael Soares Pinheiro Lucas Souto Nacif Rubens Macedo Arantes Liliana Ducatti Rodrigo Bronze Martino Luciana Bertocco Haddad Flavio Henrique Galvao Wellington Andraus Luiz Augusto Carneiro-D'Alburquerque | 2021 | World Journal of Hepatology2021，13，1： | 1 |
| 19 | Prevalence of Subclinical Hypothyroidism in a Morbidly Obese Population and Improvement after Weight Loss Induced by Roux-en-Y Gastric Bypass显示文摘 | Cristiane M Moulin de Moraes MD Marcio C Mancini PhD Maria Edna de Melo MD Daniela Andraus Figueiredo MD Sandra Mara F Villares PhD Alessandra Rascovski PhD Bruno Zilberstein PhD Alfredo Halpern PhD | 2005 | Obesity Surgery2005，，9： | 1 |
| 20 | Simul- taneous laparoscopic resection of primary colorectal cancer and associated liver metastases: a systematic review显示文摘 | Lupinacci RM Andraus W De Paiva Haddad LB | 2014 | Tech Coloproc- tol2014，18，2： | 1 |
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