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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Biodegradation and brain tissue reaction to poly(DL- lactide- co- glycolide) microspheres显示文摘 | Menei P Daniel V Benoit J P | 1992 | Biomaterials1992，14，： | 2 |
| 3 | A transaction cost model of IT outsourcing 显示文摘 | Benoit A A Suzanne R Michel P | 2004 | Information & Management2004，41，7： | 1 |
| 4 | The significance of growth in Chironomus tentans sediment toxicity tests:relationship to reproduction and demographic endpoints显示文摘 | Sibley P K Benoit D A Ankley G T | | 0，，： | 1 |
| 5 | Sulfide controls on mercury speciation and the bioavailability in sediment pore waters显示文摘 | BENOIT J M GILMOUR C C MASON R P | 1999 | Environmental Science & Technology1999，33，： | 1 |
| 6 | Convection-enhanced delivery of nanoparticles for the treatment for brain tumors 显示文摘 | ALLARD E PASSIRANI C BENOIT J P | 2009 | Biomaterials2009，30，12： | 1 |
| 7 | Recombinant desmodus ro tundus salivary plasminogen activator crosses the blood brain barrier through a low - density lipoprotein receptor - related pro- tein- dependent mechanism without exerting neurotoxic effects 显示文摘 | Jose P Lopez - Atalaya Benoit D | 2007 | Stroke2007，38，： | 1 |
| 8 | A pharmaco-genetics study of the human glucuronosyltransferase UGT1A4显示文摘 | BENOIT B MARIE O ADAM J P | 2009 | Pharm Genomics2009，19，12： | 1 |
| 9 | Rapid improvement in sleep apnoea of acromegaly after short-term treatment with somatostatinanalogue SMS 201-995显示文摘 | Chanson P Timsit J Benoit O | 1986 | Lancet1986，1，8492： | 1 |
| 10 | Synthesis,structural characterization, experimental, and computational spectrophotometric studies of 8-quinolinyloxymethypho- sphonate compounds 显示文摘 | Man S P Benoit D M Buchaca E | 2006 | Inorg Chem2006，45，： | 1 |
| 11 | Light scattering from non-Gaussian chains显示文摘 | BENOIT H DOTY P | 1954 | J PhysChem1954，57，9： | 1 |
| 12 | Quality assessment of stereoscopic images显示文摘 | BENOIT A CALLET P L CAMPISI P | 2008 | Journal on Image and Video Processing2008，209，： | 1 |
| 13 | Cardiac toxicityof intravenous erythromycin lactobionate in preterm infants显示文摘 | Gouyon JB Benoit A Betremieux P ef al | 1994 | Pediatr Infect Dis J1994，13，9： | 1 |
| 14 | West wind climate simulation of the mountainous Yukon 显示文摘 | PINARD J P BENOIT R YU W A | 2005 | Atmosphere-Ocean2005，43，3： | 1 |
| 15 | Chemical processes at the sediment-water interface 显示文摘 | SANTSCHI P HOHENER P BENOIT G | 1990 | Marine Chemistry1990，30，： | 1 |
| 16 | Quality Assessment of Stereoscopic Image显示文摘 | Benoit A Callet P L Campisi P | | 0，，： | 1 |
| 17 | Pesticide desorption from soils facilitated by dissolved organic matter coming from composts: ex- perimental data and modelling approach显示文摘 | Barriuso E Andrades M S Benoit P | 2011 | Biogeochemistry2011，106，： | 1 |
| 18 | Multiple-object auctions with budget constrained bidders 显示文摘 | Benoit J P Krishna V | 2001 | Review of Economic Studies2001，68，1： | 1 |
| 19 | Chemical processes at the sediment-water interface显示文摘 | Santschi P H H(o)ehener P Benoit G Brink M B | 1990 | Mar Chem1990，30，： | 1 |
| 20 | The diagnostic use of the second oscillatory potential in clinical electroretinography 显示文摘 | Lachapelle P Benoit J Little JM | 1989 | Doc Ophthalmol1989，73，： | 1 |
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