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| 1 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways显示文摘Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis(Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anticancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt(also known as protein kinase B) and AMP-activated protein kinase(AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed. | Do Luong Huynh Neelesh Sharma Amit Kumar Singh Simrinder Singh Sodhi ZHANG Jiao-Jiao Raj Kumar Mongre Mrinmoy Ghosh Nameun Kim Yang Ho Park Dong Kee Jeong | 2017 | Chinese Journal of Natural Medicines2017，15，1： | 32 |
| 2 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
| 3 | Immunofluorescence on paraffin embedded renal biopsies:Experience of a tertiary care center with review of literature显示文摘AIM To describe the technique of immunofluorescence on paraffin embedded tissue sections and discuss the potential pitfalls with an in depth review of literature.METHODS Immunofluorescence is integral to diagnostic renal pathology. Immunofluorescence on paraffin embedded renal biopsies(IF-P) after enzyme treatment has been described in literature, however has not found widespread use in renal pathology laboratories. In our laboratory proteinase K digestion of paraffin embedded renal biopsy material was standardized and applied prospectively in cases where immunofluorescence on fresh frozen tissue was non contributory or not possible. Diagnostic utility was assessed and in a cohort of cases comparison of intensity of staining with routine immunofluorescence was performed. RESULTS Over the 5-year study period, of the 3141 renal biopsies received IF-P was performed on 246 cases(7.7%) and was interpretable with optimal digestion in 214 cases(6.8%). It was of diagnostic utility in the majority of cases, which predominantly included glomerular disease. Nondiagnostic IF-P was found in membranous nephropathy(2 of 11 cases), membranoproliferative glomerulonephritis(2 of 32 cases), lupus nephritis(1 of 25 cases), post infectious glomerulonephritis(1 of 11 cases) and chronic glomerulonephritis(3 of 8 cases). Comparing cases with both routine IF and IF-P, 35 of 37 showed either equal intensity or a minor difference in intensity of staining(1+) for the diagnostic immunoglobulin/complement. Technically assessment of immunofluorescence on the paraffin embedded tissue was found to be easier with clearly observed morphology, however a false positive staining pattern was observed in under-digested tissue. CONCLUSION As a 'salvage' technique, immunofluorescence on paraffin embedded renal biopsies is of great diagnostic utility, however not without pitfalls. | Geetika Singh Lavleen Singh Ranajoy Ghosh Devajit Nath Amit Kumar Dinda | 2016 | World Journal of Nephrology2016，5，5： | 3 |
| 4 | Multi-criteria land evaluation for suitability analysis of wheat:a case study of a watershed in eastern plateau region,India显示文摘Improper land use results in land degradation as well as decline in agricultural productivity.To obtain optimum benefit from the land,proper utilization of its resources is necessary.Land suitability analysis is the evaluation and grouping of specific areas of land in terms of their suitability for a defined use,which is a precondition for sustainable land use planning.This study investigated the applicability of Geographical Information System(GIS)techniques in combination with multi-criteria land evaluation for analysing land suitability.The study used the weighted overlay technique for multi-criteria evaluation with GIS for the assessment of suitability of wheat cultivation in Beko watershed(Purulia,India).The watershed area is moderately suitable for wheat crop production,with constraints like imperfect drainage and poor soil depth. | Aditi SARKAR Amit GHOSH Pabitra BANIK | 2014 | Geo-Spatial Information Science2014，17，2： | 3 |
| 5 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 6 | Gastric food retention at endoscopy is associated with severity of liver cirrhosis显示文摘BACKGROUND Gastrointestinal symptoms are prevalent in patients with cirrhosis.Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis.However,the contributing factors have not been fully elucidated.Retained gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity.Therefore,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver disease.Additionally,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of cirrhosis.AIM To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated factors.METHODSWe performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated factors.RESULTSOverall, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P = 0.015), opioid use (P = 0.004),Child-Pugh class C (24.1% Child-Pugh class C vs 6.4% Child-Pugh class A, P =0.007), and lower platelet count (P = 0.027). On multivariate logistic regressionanalysis, in addition to the presence of cirrhosis (adjusted OR = 5.83;95%CI: 2.32-14.7, P < 0.001), diabetes mellitus (types 1 and 2 combined) (OR = 2.34;95%CI:1.08-5.06, P = 0.031), opioid use (OR = 3.08;95%CI: 1.29-7.34, P = 0.011), andChild-Pugh class C (OR = 4.29;95%CI: 1.43-12.9, P = 0.01) were also associatedwith a higher likelihood of food retention on EGD.CONCLUSIONCirrhotics have a higher frequency of retained food at EGD than non-cirrhotics.Decompensated cirrhosis, defined by Child-Pugh class C, is associated with ahigher likelihood of delayed gastric emptying. | David B Snell Shirley Cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul J Christos Arun B Jesudian | 2019 | World Journal of Hepatology2019，11，11： | 2 |
| 7 | Preface显示文摘This conference on Femtochemistry,Femtobiology,and Femtophysics(Femto IX)was organized in Beijing during the period of August8-13,2009.The event was timely not only because of the rise of science and technology in China and neighboring Asian countries but also because of the cultural and economic | Arne K DAHLE Amit K GHOSH | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 2 |
| 8 | Preparation of NiFe_2O_4 nanopowder via EDTA precursor and study of its properties显示文摘An ethylene diamine tetra acetic acid (EDTA) precursor-based chemical method is reported for preparing single-phase nickel ferrite (NiFe 2 O 4 ) nanopowder. The synthesized powder was characterized by thermogravimetric analysis, differential scanning calorimetric analysis, X-ray diffraction, particle size analysis and scanning electron microscopy. DC electrical resistivity and magnetic property of the syn- thesized NiFe 2 O 4 were measured by using a two-probe method and a vibrating sample magnetometer respectively. The DC resistivity behaviour of the NiFe 2 O 4 nanopowder was correlated with the change of microstructure, during sintering. This EDTA precursor-based method is capable of producing nanos- tructured single-phase NiFe 2 O 4 powder at a comparatively low calcination temperature and offers the potential of a simple and cost-effective route, including the preparation of other ferrite nanoparticles. | Amit B.Rajput Subhenjit Hazra Niharika B.Krishna Pavani Chavali Sneha Datla Narendra Nath Ghosh | 2012 | Particuology2012，10，1： | 1 |
| 9 | Recent development on polyphenol-protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive syetem显示文摘 | Bandyopadhyay P Amit K Ghosh | 2012 | The Royal Society of Chemistry2012，5，： | 1 |
| 10 | Tensile deformation behavior of aluminum alloy at warm forming temperature 显示文摘 | Li Daoming Amit Ghosh | 2003 | Materials Science and Engineering A2003，352，： | 1 |
| 11 | Conducting blends of poly (o-toluidine) and poly (ester) urathane显示文摘 | GHOSH PREMAMOY CHAKRABARTI AMIT KAR SWARNENDU B | 2004 | Synthetic Metals2004，144，3： | 1 |
| 12 | Appraisal of a rural co-operative with the thrust on rural development: an empirical study显示文摘 | Amit KoChakrabarty Krishnamay Ghosh | 2009 | International Journal of Social Economics2009，36，12： | 1 |
| 13 | Biaxial warm forming behavior of aluminum sheet alloys 显示文摘 | Li Daoming Amit Ghosh | 2004 | Journal of Materials Processing Technology2004，145，： | 1 |
| 14 | Tensile deformation behavior of aluminum alloys at warm forming temperatures 显示文摘 | Li Daoming Ghosh Amit | 2003 | Materials Science and Engineering2003，352，： | 1 |
| 15 | Conducting carbon black filled EPDM vulcanizates: assessment of dependene of physical and mechanical properties and conducting character on variation of filler loading显示文摘 | Ghosh Premamoy Chakrabarti Amit | 2000 | Eurropean Polymer Journal2000，36，5： | 1 |
| 16 | A Criterion for ductile fracture in sheets under biaxial loading显示文摘 | Amit K. Ghosh | 1976 | Metallurgical Transactions A1976，，3： | 1 |
| 17 | Superplasticity in a high strength powder aluminum显示文摘 | Murray W. Mahoney Amit K. Ghosh | 1987 | Metallurgical Transactions A1987，，5： | 1 |
| 18 | Biaxial warm forming behavior of aluminum Sheet alloys 显示文摘 | Li Daoming Amit K Ghosh | 2004 | Journal of Materials Processing Technology2004，145，： | 1 |
| 19 | Tensile deformation behavior of aluminum alloys at warm forming temperatures 显示文摘 | Li Daoming Amit Ghosh | 2003 | Materials Science and Engineering2003，352，： | 1 |
| 20 | A Simple Approach To Detect Caff eine in Tea Beverages显示文摘 | Ghosh Amit K Ghosh Chandrasekhar Gupta Ashutosh | 2013 | Journal of Agricultural and Food Chemistry2013，61，： | 1 |
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