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| 1 | Regulation of metabolism by the Mediator complex显示文摘 | Dou Yeon Youn Alus M. Xiaoli Jeffrey E. Pessin Fajun Yang | 2016 | Biophysics Reports2016，2，2： | 2 |
| 2 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 3 | Targeted therapy for head and neck cancer:signaling pathways and clinical studies显示文摘Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed. | Qingfang Li Yan Tie Aqu Alu Xuelei Ma Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 4 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 5 | Pairing an epsilon-negative slab with a mu-negative slab: resonance, tunneling and transparency显示文摘 | Alu A Engheta N | 2003 | IEEE Trans AP2003，51，10： | 1 |
| 6 | Multifrequency optical invisibility cloak with layered plasmonic shells显示文摘 | ALU A | 2008 | Physical Review Letters2008，100，11： | 1 |
| 7 | Distribution, antioxidant and characterisation of phenolic compounds in soybeans, flaxseed and olives显示文摘 | Alu’datt M H Rababah T Ereifej K | 2013 | Food Chemistry2013，139，14： | 1 |
| 8 | Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection显示文摘The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants.In Chengdu,China,an infection wave was predominantly induced by the BA.5 subvariant.It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection. | Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 9 | Plasmonic cloaking and scattering cancelation for electromagnetic and acoustic waves显示文摘 | GUILD M D HABERMAN M R Alu A | 2011 | Wave Motion2011，48，6： | 1 |
| 10 | Cerebral oxi- metry in neurosurgical patients with cerebraovascular dis- eases--Ⅰ: analysis of causes of intraoperative changes in rSO2 values and its prognostic significance 显示文摘 | Shmigel'skiǐ AV Lubnin Alu Sazonova OB | 2000 | Anesteziol Reanimatol2000，，4： | 1 |
| 11 | Controlling sound with acoustic metamaterials显示文摘 | Cummer S Christensen J Alu A | 2016 | Nat Rev Mater2016，，16： | 1 |
| 12 | Pairing an epsilon-negative slab with a mu-negative slab: resonance, tunneling and transparency显示文摘 | Alu A Engheta N | 2003 | IEEE Trans on An- tennas Propag2003，51，： | 1 |
| 13 | Clinical and X-ray diagnosis of initial degenerative changes in the lumbar section of the spine in flight personnel显示文摘 | Vasil′ev Alu Vit′ko NK | 1996 | Aviakosm Ekolog Med1996，30，2： | 1 |
| 14 | Sub-wavelength elliptical patch antenna loaded with μ-negative metamaterials显示文摘 | Chen P Y Alu A | 2010 | IEEE Trans on Antennas Propag2010，58，9： | 1 |
| 15 | Early postpartum breast-feeding outcomes and breast-feeding self-efficacy in Turkish mothers undergoing vaginal birth or cesarean birth with different types of anesthesia显示文摘 | Alus Tokat M Sercekus P Yenal K | 2015 | Int J Nurs Knowl2015，26，2： | 1 |
| 16 | Pairing an epsilon-negative slab with a mu- negative slab:resonance, tunneling and transparency显示文摘 | Alu A Engheta N | 2003 | IEEE Transactions on Antennas and Propagation2003，51，10： | 1 |
| 17 | EFR like peptides and their receptors as prognostic factors for the survival of patients with non-small-cell lung cancer显示文摘 | Kostyleva OI Gerstein ES Dykhno Alu | 1999 | Vopr Onkol1999，45，6： | 1 |
| 18 | M-PSK and M-QAM BER computation using signal-space concepts显示文摘 | aLU JIANHUA LETAIEF K B CHUANG J C-I | 1999 | IEEE Transactions on Communications1999，47，2： | 1 |
| 19 | All Optical Metamaterial Circuit Board at the Nanoscale显示文摘 | Andrea Alu Nader Engheta | 2009 | Phys Rev Lett2009，103，14： | 1 |
| 20 | On the relationship between crowd density and movement velocity显示文摘 | Z Fang S M Lo J ALu | 2003 | Fire Safety Journal (S0379-7112)2003，38，： | 1 |
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