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| 1 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Oral versus intravenousibuprofen for patent ductus arteriosus closure: A randomisedcontrolled trial in extremely low birthweight infants显示文摘 | Erdeve O Yurttutan S Altug N | 2012 | Arch DisChild Fetal Neonatal Ed*2012，97，4： | 1 |
| 3 | Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts显示文摘 | Altug S Demiryurek AT Kane KA | 2000 | Br J Pharmacol2000，130，： | 1 |
| 4 | Treatment rationale and study design for a phaseⅢ,double-blind,placebo-control ed study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced n显示文摘 | Paz-Ares LG Altug S Vaury AT | | 0，，： | 1 |
| 5 | Treatment rationale and study design for a phase Ⅲ, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus Cisplatin for advanced non-squamous non-small cell lung cancei显示文摘 | Paz -Ares LG Altug S Vaury AT | 2010 | BMC cancer2010，10，： | 1 |
| 6 | Effect of 2elastomeric ligatures on microbial flora and periodontal status in orthodonticpatients 显示文摘 | Akgun OM Altug H Karacay S | 2014 | Am J Orthod Dentofacial Orthop2014，145，5： | 1 |
| 7 | Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely lowbirth weight infants显示文摘 | Oncel MY Yurttutan S Degirmencioglu H Uras N Altug N Erdeve O | 2013 | Neonatology2013，103，3： | 1 |
| 8 | Treatment ra- tioale and study design for a phase Ⅲ, double-blind, placebo- controlled study of maintenance pemrtrexed plus best support- ive care versus best supportive care immediately following in- duction treatment with pemetrexed plis cisplatin for advanced nonsquamous non-small cell lung cancer显示文摘 | Paz Ares L G Altug S Vaury A T | 2010 | BMC Cancer2010，10，1： | 1 |
| 9 | Fuzzy inference systems implemented on neural architectures for motor fault detection and diagnosis显示文摘 | ALTUG S CHOW M Y TRUSSELL H J | 1999 | IEEE Transactions on Industrial Electronics1999，46，6： | 1 |
| 10 | Cancer associated fibroblasts have phenotypic and functional characteristics similar to the fibrocytes that represent a novel MDSC subset显示文摘 | Gurcan Gunaydin S Altug Kesikli Dicle Guc | 2015 | OncoImmunology2015，，9： | 1 |
| 11 | Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts显示文摘 | Altug S Demiryurek AT Kane KA | 2000 | Br J Pharmacol2000，130，： | 1 |
| 12 | Near-IR absorbing ph- thalocyanines显示文摘 | YASIN A ALTUG M S ESIN H | 2006 | Dyes and Pigments2006，68，： | 1 |
| 13 | Effects of cyclooxygenase inhibitors on nitric oxide production and sur- vival in a mice model of sepsis 显示文摘 | TUNCTAN B ALTUG S ULUDAG O | 2003 | Pharmacol Res2003，48，1： | 1 |
| 14 | Oral versus intravenous ibuprofen for patent ductus arteriosus closure:a randomised controlled trial in extremely low birthweight infants显示文摘 | Erdeve O Yurttutan S Altug N | | 0，，04： | 1 |
| 15 | Treatment rationale and study design for a phase Ⅲ, double- blind, placebo- con- trolled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treat-ment with pemetrexed plus cisplatin for advanced nonsquamous non --small cell lung cancer显示文摘 | Paz-Ares L G Altug S Vaury A T | 2010 | BMC Cancer2010，8，10： | 1 |
| 16 | , 1989, Time-to-build and Aggregate Fluctuations: Some New Evidence 显示文摘 | Altug S | 1989 | Interna- tional Economic Review1989，，： | 1 |
| 17 | Fuzzy inference systems im- plemented on neural architectures for motor fault detection and diagnosis显示文摘 | Altug S Chow M Y Trussell H Z | 1999 | IEEE Transactions on Industry Electronics1999，46，6： | 1 |
| 18 | Treatment rationale and study design for a phase Ⅲ,double-blind,placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced 显示文摘 | Paz-Ares LG Altug S Vaury AT | | 0，，： | 1 |
| 19 | Treatment rationaleand study design for a phase 瓜,double-blind,placebo-con-trolled study of maintenance pemetrexed plus best supportivecare versus best supportive care immediately following induc-tion treatment with pemetrexed plus cisplatin for advancednonsquamous non-small cell lung cancer 显示文摘 | Paz-Ares LG Altug S Vaury AT | 2010 | BMC Cancer2010，10，： | 1 |
| 20 | Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts显示文摘 | Demiryurek AT Kane KA | 2000 | Br J Pharmaco2000，130，1： | 1 |
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