|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Pancreatic adenocarcinoma: detec tion and staging with dynamic MR imaging显示文摘 | Obuz F Dicle O Coker A | 2001 | Eur J Radiol2001，38，2： | 1 |
| 3 | Seismic retrofitting of highway bridges in Illinois using friction pendulum seismic isolation bearings and modeling procedures 显示文摘 | Dicleli Murat Mansour Mohamad | 2003 | Engineering Structures2003，25，： | 1 |
| 4 | Critical truck loading pattern to maximize live load effects in skewed integral bridges显示文摘 | DICLELI M YALCIN O F | 2014 | Structural Engineering International2014，24，2： | 1 |
| 5 | Effect of soil and substructure properties on live-load distribution in integral abutment bridges显示文摘 | DICLELI M ERHAN S | 2008 | Journal of Bridge Engineering2008，13，5： | 1 |
| 6 | Static Soil Structure Interac- tion Effects in Seismic - Isolated Bridges 显示文摘 | Dicleli M Albhaisi S Mansour M Y | 2005 | Practice Periodical on Structural Design and Construction ASCE2005，10，1： | 1 |
| 7 | Comprehensive evaluation of equivalent linear analysis method for seismic-isolated structures represented by Sdof systems 显示文摘 | MURAT DICLELI SRIKANTH BUDDARAM | 2007 | Engineering Structures2007，29，8： | 1 |
| 8 | Effect of near-fault ground motion and damper characteristics on the seismic performance of chevron braced steel frames 显示文摘 | DICLELI M | 2007 | Earthquake Engineering & Structural Dynamics2007，36，： | 1 |
| 9 | An Energy Approach to Sliding of Single-span Simply Supported Slab-on-girder Steel Highway Bridges with Damaged Bearings显示文摘 | Dicleli M Bruneau M | 1995 | Earthquake Engineering and Structural Dynamics1995，24，3： | 1 |
| 10 | A comparison of problem- based and traditional education on nursing students' critical thinking dispositions 显示文摘 | Ozturk C Muslu GK Dicle A | 2008 | Nurse Educ Today2008，28，5： | 1 |
| 11 | A comparison of problem-based and traditional education on nursing students' critical thinking dispositions 显示文摘 | Ozturk C Muslu GK Dicle A | 2008 | Nurse Educ Today2008，28，5： | 1 |
| 12 | Static soil-structure interaction effects in seismic-isolated bridges 显示文摘 | Dicleli M Albhaisi S Mansour M Y | 2005 | Practice Periodical on Structural Design and Construction2005，10，1： | 1 |
| 13 | Integral Abutment-backfill Behavior on Sand Soil-Pushover Analysis Approach显示文摘 | DICLELI M | 2005 | Journal of Bridge Engineering2005，10，3： | 1 |
| 14 | Performance of Abutment-backfill System Under Thermal Variations in Integral Bridges Built on Clay显示文摘 | DICLELI M ALBHAISI S M | 2004 | Engineering Structures2004，26，7： | 1 |
| 15 | Seismic performance of multispan simply supported slab-on-girder steel highway bridges显示文摘 | Dicleli M Bruneau M | 1995 | Engineering Structures1995，17，1： | 1 |
| 16 | Unusual location of purpura fulminans associated with acquired protein C deficiency and administration of propyhhiouracil 显示文摘 | Akman A Dicle O Ciftcioglu MA | 2009 | Clin Exp Dermatol2009，34，7： | 1 |
| 17 | Supplemental elastic stiffness to reduce isolator displacements for seismic-isolated bridges in near-fault zones显示文摘 | Dicleli M | | 0，，05： | 1 |
| 18 | Parametric analysis of optimum isolator properties for bridges susceptible to near-fault ground motions显示文摘 | Karalar M Padgett J E Dicleli M | | 0，，40： | 1 |
| 19 | A comparison of problem-based and traditional education on nursing students'critical thinking dispositions 显示文摘 | Ozturk C Muslu GK Dicle A | 2008 | Nurse Educ Today2008，28，5： | 1 |
| 20 | Seismic design of lifeline bridge using hybrid seismic isolation显示文摘 | Dicleli M | 2002 | Journal of Bridge Engineering2002，7，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员