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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | HighcorrosionGresistantNiGP/Ni/NiGPmultilayercoatingsonsteel显示文摘 | GuC LianJ LiG etal | 2005 | Surface&CoatGingsTechnology2005，197，1： | 1 |
| 3 | The involment of nitric oxide in the analgesic effects of Ketamine显示文摘 | Bulutcu F Dogrul A Guc MD | | 0，，07： | 1 |
| 4 | Expression of complement regulatory proteins CR1, DAF, MCP and CD59 in haematological malignancies 显示文摘 | Guc D Canpinar H Kucukaksu C | 2000 | Eur J Haemato12000，64，1： | 1 |
| 5 | HighcorrosionGresistantNiGP/Ni/NiGP multilayerscoatingsonsteel 显示文摘 | GuC LianJ LiG etal | 2005 | Surf CoatTechnol2005，197，1： | 1 |
| 6 | Oral versus intranasal midazolam premeditation for infants during echocardiographic study 显示文摘 | Yildirim SV Guc BU Bozdogan N | 2006 | Adv Ther2006，23，5： | 1 |
| 7 | Ulinastatin improves pul- monary function in severe burn- induced acute lung injury by attenuating inflammatory response 显示文摘 | Fang Y Xu P GuC | 2011 | J Trauma2011，71，5： | 1 |
| 8 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmaeol Sin2003，24，10： | 1 |
| 9 | The assessment and management of chronic cough in children according to the British Thoracic Society guidelines : descriptive, prospective, clinical trial 显示文摘 | Usta Guc B Asilsoy S Durmaz C | 2014 | Clin Respir J2014，8，3： | 1 |
| 10 | Evidence that aminoguanidine inhibits endotoxin - induced bacterial translocation显示文摘 | Agalar B K C Guc M O Sayek I | 1998 | Br J Surg1998，85，： | 1 |
| 11 | Expression of complement regulatory proteins CR1,DAF,MCP and CD59 in haematological malignancies显示文摘 | Guc D Canpinar H Kucukaksu C | | 0，，01： | 1 |
| 12 | Towards trajectory anonymization:a generalization-based approach显示文摘 | M E Nergiz M Atzori Y Saygin B Guc | 2009 | Transactions on Data Privacy2009，2，1： | 1 |
| 13 | Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment显示文摘 | Guc helaar HJ Vermes A Meerwaldt JH | 1997 | Support Care Cancer1997，5，4： | 1 |
| 14 | The involvement of nitric oxide in the analgesic effects of ketamine显示文摘 | Bulutcu F Dogrul A Guc MO | 2002 | Life Science2002，71，7： | 1 |
| 15 | Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing显示文摘 | Martino MM Briquez PS Guc E | 2014 | Science2014，343，6173： | 1 |
| 16 | IL-17family:cytokines,receptorsandsigna-ling显示文摘 | GuC WuL LiX | 2013 | Cytokine2013，64，2： | 1 |
| 17 | The assessment and manage ment of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial显示文摘 | Usta Guc B Asilsoy S Durmaz C | 2014 | Clin Respir J2014，8，3： | 1 |
| 18 | Expression of complement regulatory proteins CRI, DAF, MCP and CD59 in haematological malignancies 显示文摘 | Guc D Canpinar H Kucukaksu C | 2000 | Eur J Haematol2000，64，1： | 1 |
| 19 | Expression of complement regulatory proteins CR1,DAF,MCP and CD59 in haematological malignancies显示文摘 | Guc D Canpinar H Kucukaksu C | | 0，，01： | 1 |
| 20 | The assessment and management of chronic cough in children according to the British Thoracic Society guidelines:descriptive,prospective,clinical trial显示文摘 | Usta Guc B Asilsoy S Durmaz C | 2014 | Clin Respir J2014，8，3： | 1 |
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