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| 1 | Relationship of functional gastrointestinal disorders and psychiatric disorders: Implications for treatment显示文摘这篇文章重游在象急躁的肠症候群( IBS )那样的精神病理学和功能的胃肠的混乱之间的连接,讨论抗抑郁剂的合理使用以及非药理学来临到 IBS 的管理,并且从知识的现在的状态基于一个学科交差的观点为 IBS 的处理建议指南。精神病学的混乱上的相关出版文学,特别躯体化混乱在 IBS 的上下文,并且为管理的文学提供方向被考察,并且新方向在文学从调查结果被提供。IBS 是有为它的临床的演讲负责的各种各样的潜在的机制的异构的症候群。IBS 与在另外的机关系统的精神病学的问题, unexplained 症状,和功能的症候群典型地是复杂的。没有表明的原因,大多数 IBS 病人有多重抱怨,并且这些症状能包含除肠以外的系统,例如骨头和关节(fibromyalgia,颞下颌关节症候群) ,心(非心脏的胸痛) ,脉管(绝经后的症候群) ,并且大脑(焦虑,消沉) 。大多数 IBS 病人没有精神病学的病伴随他们的 somatoform (当医药混乱不在时的物理症状) 的精神分析形式(当精神病学的混乱不在时的心理抱怨) 的本身,而是一个范围症状抱怨。作为精神病学的病人把 IBS 病人标记不是正确的(除了有真躯体化的那些更困难的病人混乱) 。治疗的一个模式是不大可能的普遍有效或解决大多数症状。心理疗法或认知行为的治疗的技术能允许 IBS 病人与他们的病更乐意地处理。特定的事件压抑或焦虑混乱能为那些条件作为适当被管理。设计改进焦虑或消沉的药不为在 IBS 的精神病学的抱怨是一致地有用的,因为听起来类似于在精神病学的混乱看见的那些的精神分析形式症状不能与 IBS 在病人有一样的意义。 | Carol S North Barry A Hong David H Alpers | 2007 | World Journal of Gastroenterology2007，13，14： | 17 |
| 2 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 3 | Diagnostic accuracy of clinical symptoms and signs in children w:th meningitis 显示文摘 | Amarilyo G Alper A Ben - Tov A | 2011 | Pediatr Errverg Care2011，27，3： | 1 |
| 4 | Highly reliable genetic identification of individual northern hairy - nosed wombats from sin- gle remotely collected hairs: a feasible censusing method 显示文摘 | Sloane M A Sunnucks P Alpers D | 2000 | Mo- lecular Ecology2000，9，9： | 1 |
| 5 | The effect of high-flux hemodialysis on renal anemia显示文摘 | Deniz A Meltem A Alper A | 2004 | Journal of Nephrology2004，17，5： | 1 |
| 6 | Complex expression of nature killer receptor genes in single natural killer cells 显示文摘 | Husain H Alper C A Yunis E J | 2002 | Immunology2002，106，3： | 1 |
| 7 | Alterations in T4 (CD,) protein and mRNA synthesis in cells infected with HIV 显示文摘 | HOXIE J A ALPERS J D RACKOWSKI J L | 1986 | Science1986，234，4780： | 1 |
| 8 | High-frequency sensorineural hearing loss in patients with ankylosing spondylitis:is it an extrarticuler feature of disease显示文摘 | Mehmet A Alper NE Didem A | | 0，，： | 1 |
| 9 | Hemodynamic shear stress and its role in atherosclerosis显示文摘 | Malek A M Alper S L Izumo S | 1999 | JAMA1999，282，21： | 1 |
| 10 | Hemodynamic shear stress and its role in atherosclerosis 显示文摘 | Alper S L Izumo S | 1999 | JAMA1999，282，： | 1 |
| 11 | Childhood uric acid predicts adult blood pressure显示文摘 | ALPER A B CHEN W YAU L | 2005 | Hypertension2005，45，： | 1 |
| 12 | Myo- cardial infarction rardefined: a consensus doncument of the re - dryintition krmyocardial infovrction 显示文摘 | Alper JS Thygesen K Antman E et a| | 2011 | J AM Coll Caidiol2011，36，： | 1 |
| 13 | Rat intestinal alkaline phosphatase secretion into lumen and serum is coordinately regulated显示文摘 | Elialim R Mahmood A Alpers DH | 1991 | Bioehim Biophys Acta1991，1091，： | 1 |
| 14 | Long-term results of surgery for liver hemangiomas 显示文摘 | Ozden I Emre A Alper A | 2000 | Arch Surg2000，135，12： | 1 |
| 15 | Probing the gold nanorod-ligand-solvent interface by plasmonie absorption and thermal decay显示文摘 | Schmidt A J Alper J D Chiesa M | 2008 | Journal of Physical Chemistry C2008，，13： | 1 |
| 16 | A three-level hysteresis function approach to the sliding-mode control of single-phase UPS inverters显示文摘 | Kukrer O Komurcugil H Alper Doganalp A | 2009 | IEEE Transactions on Industrial Electronics2009，56，9： | 1 |
| 17 | Directed differentiation of human embryonic stem ceils into functional retinal pigment epithelium cells 显示文摘 | Idelson M Alper R Obolensky A Shushan EB Hemo L Cohen NY | 2009 | Cell Stem Ceii2009，5，4： | 1 |
| 18 | long term results of surgery for liver hemangiomas 显示文摘 | Ozden I Emre A Alper A | 2000 | Arch Surg2000，135，8： | 1 |
| 19 | Membranes of poly(ether imide) and nanodispersed silica显示文摘 | S.P Nunes K.V Peinemann K Ohlrogge A Alpers M Keller A.T.N Pires | 1999 | Journal of Membrane Science1999，，2： | 1 |
| 20 | Hemodynamic shear stress and its role in atherosclerosis显示文摘 | MALEK A M ALPER S L IZUMO S | 1999 | JAM A1999，282，20： | 1 |
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