|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | ESPEN Guidelines for nutrition screening 2002 显示文摘 | Kondrup J Allison P Elia M | 2003 | Clin Nutr2003，22，4： | 1 |
| 5 | ESPEN guidelines for nutri tion screening 2002显示文摘 | Kondrup J Allison S P Elia M | 2003 | Clin Nutr2003，22，4： | 1 |
| 6 | ESPEN guidelines fnr nutrition screening 2002显示文摘 | KONDMP J ALLISON S P ELIA M | 2003 | Clin Nutr2003，22，4： | 1 |
| 7 | ESPEN Guide- lines for Nutrition Screening 2002 显示文摘 | KONDRUP J ALLISON S P ELIA M | 2003 | Clin Nutr2003，22，4： | 1 |
| 8 | Seasonal chemical and isotopic variations of soil CO2 at Trout Creek,Outario显示文摘 | REARDON E J ALLISON G B FRITZ P | 1979 | Journal of Hydrology1979，43，1： | 1 |
| 9 | Resonance response of scanning force mi- croscopy cantilevers显示文摘 | Chen G Y Warmack R J Thundat T Allison D P Huang A | 1994 | Review of Scientific Instru-ment1994，65，8： | 1 |
| 10 | The effects of customized site features on internet apparel shopping 显示文摘 | Kiseol Yang Allison P Young | 2009 | Journal of Fashion Marketing and Management2009，13，1： | 1 |
| 11 | An evaluation of the potential of the multiple antibiotic resistance operon(mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms显示文摘 | Maria-Litran T Allison DG Gilbert P | 2000 | J Antimicrob Chemother2000，45，： | 1 |
| 12 | Thermal and ambient-induceddeflections of scanning force microscope cantilevers显示文摘 | Thundat T Warmack R J Chen O Y Allison D P | 1994 | Applied Physics Let- ters1994，64，21： | 1 |
| 13 | PD-L1 and PD-L2 are differentially regulated by Thl and Th2 cells显示文摘 | Loke P Allison JP | 2003 | Proc Natl Acad Sci U S A2003，100，9： | 1 |
| 14 | An improved non-selective culture medium for animal bacterial and its use in determining diurnal variation in numbers of bacteria in the rumen显示文摘 | Allison I M | 1961 | J Dairy Sci1961，44，： | 1 |
| 15 | Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis 显示文摘 | ALLISON M A CHEUNG P CRIQUI M H | 2006 | Circulation2006，113，6： | 1 |
| 16 | Randomized trial of hydroxyethyl starch versus gelatine for trauma resuscitation显示文摘 | Allison KP Gosling P Jones S | 1999 | J Trauma1999，47，6： | 1 |
| 17 | Responses of extracellular enzymesto simple and complex nutrient inputs显示文摘 | ALLISON S D VITOUSEK P M | 2005 | Soil Biology and Biochem-istry2005，37，5： | 1 |
| 18 | Transformation of and Heterologous Protein Expression in,Lactobacillus agilis and Lactobacillus vaginalis Isolates from the Chicken Gastrointestinal Tract显示文摘 | STEPHENSON D P MOORE RJ ALLISON G E | | 0，，1： | 1 |
| 19 | Growth rate control of adher- ent bacterial populations 显示文摘 | Gilbert P Allison DG Evans DJ | 1989 | Appl Environ Microbiol1989，55，5： | 1 |
| 20 | CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation显示文摘 | Krumme Allison J P | 1995 | J Immunoh1995，182，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员