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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Predictive value of cell cycle markers p53,mdm2,p21 and ki-67 in superficial bladder tumor recurrence显示文摘 | Pfister C Moore L Allard P | 1999 | Clin Cancer Res1999，5，： | 1 |
| 3 | Oxide supported MoS2 catalysts of unusual morphology 显示文摘 | Datye A K Srinivasan S Allard L F | 1996 | J Catal1996，158，： | 1 |
| 4 | Th2 allergic immune re- sponse to inhaled fungal antigens is modulated by TLR-4-inde- pendent bacterial products 显示文摘 | Allard J B Rinaldi L Wargo M J | 2009 | Eur J Immunol2009，39，3： | 1 |
| 5 | Fatty Acid Binding Protein as a Serum Marker for the Early Diagnosis of Stroke:A Pilot Study显示文摘 | Zimmermann Ivol C G Burkhard P K Allard L | 2004 | Mol Cell Proteomics2004，3，1： | 1 |
| 6 | Effect of preoxidation on the nucleation an growth behavior of chemically vapor-de- posited a-A1203 on a single-crystal Ni-based superalloy 显示文摘 | He L M Su Y F Allard L F | 2004 | Metallurgical and Materials Transactions A2004，35，13： | 1 |
| 7 | Fe-Cu two-phase nanocomposites: ap- plication of a modified rule of mixtures显示文摘 | HE L Allard L F MA E | 2000 | Scripta Materialia2000，42，： | 1 |
| 8 | Preeclampsia is associated with an increased pro-inflammatory profile in newbo rns显示文摘 | Guillemette L Lacroix M Allard C | 2015 | J Reprod Immunol2015，112，： | 1 |
| 9 | Solubilization of single-walled carbon nanotubes with diamine-terminated oligo- meric poly (ethylene glycol) in different functionalization reac- tions~显示文摘 | Huang W J Femando S Allard L F | 2003 | Nano Lett2003，3，： | 1 |
| 10 | ApoC-I and ApoC-Ⅲ as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke显示文摘 | Allard L Lescuyer P Burgess J | 2004 | Proteomics2004，4，： | 1 |
| 11 | Isolation and characterization of a polygalacturonase gene highly expressed in Brassica napus pollen显示文摘 | Robert L S Allard S Gerster J L | 1993 | Plant Molecular Biology1993，23，6： | 1 |
| 12 | The accuracy of noninvasive and continuous total hemoglobin measurement by pulse CO-Oximetry in human subjects undergoing hemodilution显示文摘 | MACKNET M R ALLARD M APPLEGATE R L 2nd | 2010 | Anesth Analg2010，111，6： | 1 |
| 13 | How we manage the haematological aspects of major obstetric haemorrhage显示文摘 | ALLARD S GREEN L HUNT BJ | 2014 | Br J Haematol2014，164，2： | 1 |
| 14 | Estima- tion of life cycle components of selection in an experi- mental plant population 显示文摘 | CLEGG M T KAHLER A L ALLARD R W | 1978 | Genetics1978，89，4： | 1 |
| 15 | The effect of overexpres- sion of two Brassica CBF/DREBI-like transcription factors on photosynthetic capacity and freezing tolerance in Brassica napus 显示文摘 | Savitch L V Allard G Seki M | 2005 | Plant Cell Physiol2005，46，9： | 1 |
| 16 | The accuracy of noninvasive and continuous total hemo- globin measurement by pulse CO-Oximetry in human sub- jects undergoing hemodilution显示文摘 | MACKNET M R ALLARD M APPLEGATE R L | 2010 | Anesthesia & Ana-lge- sia2010，111，6： | 1 |
| 17 | Regulation and characterization of four CBF transcription factors from l:rassica napus显示文摘 | Gao M J Allard G Byass L | 2002 | Plant Molecular Biology2002，49，5： | 1 |
| 18 | Regulation and characterization of four CBF transcription factors from Brassica napus显示文摘 | Gao M J Allard G Byass L | 2002 | Plant Molecular Biology2002，49，5： | 1 |
| 19 | Fungal allergen beta- glucans trigger p38 mitogen-aetivated protein kinase-mediated IL-6 translation in lung epithelial cells显示文摘 | Neveu W A Bemardo E Allard J L | 2011 | Am J Respir Cell Mol Biol2011，45，6： | 1 |
| 20 | Atomic structure of a lithium-rich layered oxide material for lithium-ion batteries: evi- dence of a solid solution显示文摘 | JARVIS K A DENG Z ALLARD L F | 2011 | Chemistry of Materials2011，23，16： | 1 |
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