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| 1 | Clinical approaches to non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH),leading to fibrosis and potentially cirrhosis,and it is one of the most common causes of liver disease worldwide.NAFLD is associated with other medical conditions such as metabolic syndrome,obesity,cardiovascular disease and diabetes.NASH can only be diagnosed through liver biopsy,but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis,reducing the need for liver biopsy and risk to patients.Disease progression varies between individuals and is linked to a number of risk factors.Mechanisms involved in the pathogenesis are associated with diet and lifestyle,influx of free fatty acids to the liver from adipose tissue due to insulin resistance,hepatic oxidative stress,cytokines production,reduced very low-density lipoprotein secretion and intestinal microbiome.Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD.Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial.Omega 3 polyunsaturated fatty acids and statins may offer additional benefits.Bariatric surgery should be considered in morbidly obese patients.More research is needed to assess the impact of these treatments on a long-term basis.The objective of this article is to briefly review the diagnosis,management and treatment of this disease in order to aid clinicians in managing these patients. | Katherine JP Schwenger Johane P Allard | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 3 | Typing of rhizobia by PCR DNA finger and PCR-restriction fragment length polymorphism analysis of chromosomal and symbiotic gene regions:application to Rhizobium leguminosarum and its different biovars显示文摘 | LAGUERRE G MAVINGUI P ALLARD M R | 1996 | Appl Environ Microbiol1996，62，： | 1 |
| 4 | Predictive value of cell cycle markers p53,mdm2,p21 and ki-67 in superficial bladder tumor recurrence显示文摘 | Pfister C Moore L Allard P | 1999 | Clin Cancer Res1999，5，： | 1 |
| 5 | Convection-enhanced delivery of nanoparticles for the treatment for brain tumors 显示文摘 | ALLARD E PASSIRANI C BENOIT J P | 2009 | Biomaterials2009，30，12： | 1 |
| 6 | The early clinical course of primary Ta and T1 bladder cancer: a proposed prognostic in- dex显示文摘 | Allard P Bernard P Fradet Y | 1998 | BrJ Urol1998，81，5： | 1 |
| 7 | Fatty Acid Binding Protein as a Serum Marker for the Early Diagnosis of Stroke:A Pilot Study显示文摘 | Zimmermann Ivol C G Burkhard P K Allard L | 2004 | Mol Cell Proteomics2004，3，1： | 1 |
| 8 | Polymerase chain reaction for detection of adenoviruses in stool samples 显示文摘 | Girones R Juto P | 1990 | J Clin Microbiol1990，28，12： | 1 |
| 9 | Education in ter-ventions improve cancer pain control:a systematic review显示文摘 | ALLARD P MAUNSELL E LABBE J | 2001 | JPalliat Med2001，4，2： | 1 |
| 10 | Development of sediment quality values for Hong Kong Special Administrative Region:a possible model for other jurisdictions显示文摘 | Chapman P M Allard P J Vigers G A | 1999 | Marine Pollution Bulletin1999，38，3： | 1 |
| 11 | Bilateral gait patterns in subjects fitted with a total hip prosthesis显示文摘 | Loizeau J Allard P Duhaime M | 1995 | Arch Phys Med Rehabil1995，76，： | 1 |
| 12 | Nutrition Risk Factors for Survival in the Elderly Living in Canadian Long- term Care Facilities显示文摘 | Allard J P Aghdassi E McArthur M | 2004 | J Am Geriatr Soc2004，52，1： | 1 |
| 13 | The early clinical course of primary Ta and T1bladder cancer:aproposed prognostic index显示文摘 | Allard P Bernard P Fradet Y | 1998 | Br J Urol1998，81，5： | 1 |
| 14 | ApoC-I and ApoC-Ⅲ as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke显示文摘 | Allard L Lescuyer P Burgess J | 2004 | Proteomics2004，4，： | 1 |
| 15 | Nitrogen partitioning and remobilization in relation to leaf senescence, grain yield and grain nitrogen concentration in wheat cuhivars 显示文摘 | Gaju O Allard V Martre P | 2014 | Field Crops Research2014，155，： | 1 |
| 16 | Education Interventions to Improve Cancer Pain Control:A Sysmetic Review显示文摘 | Allard P Maunsell E Labbé J | 2001 | J Palliat Med2001，4，2： | 1 |
| 17 | Relations between standing stability and body posture parameters in adolescent idiopathic scoliosis显示文摘 | Nault ML Allard P Hinse S | 2002 | Spine2002，27，17： | 1 |
| 18 | Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities 显示文摘 | Allard P Colaiaeovo MP | 2010 | Proc Natl Acad Sci U S A2010，107，20： | 1 |
| 19 | Can molluscan assemblages give insights into Holoene environmental changes other lhan sea level rise? A case study from a macrotidal bay ( Marennes O1 rnn, France ) 显示文摘 | POIRIER C SAURIAU P CHAUMILLON E ALLARD J | 2009 | Palaeogeography Palaeoclimalology Palaeneeology2009，280，12： | 1 |
| 20 | Caring for a Loved One with Advanced Cancer: Determinants of Psychological Distress in Family Caregivers显示文摘 | Dumont S Turgeon J Allard P | 2006 | Journal of Palliative Medicine2006，9，4： | 1 |
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