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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Typing of rhizobia by PCR DNA finger and PCR-restriction fragment length polymorphism analysis of chromosomal and symbiotic gene regions:application to Rhizobium leguminosarum and its different biovars显示文摘 | LAGUERRE G MAVINGUI P ALLARD M R | 1996 | Appl Environ Microbiol1996，62，： | 1 |
| 3 | Zn, Cd and Hg accumulation by microorganisms, organic and inorganic soil components in multi-compartment systems 显示文摘 | Ledin M Krantz-Rulcker C Allard B | 1996 | Soil Biology and Biochemistry1996，28，6： | 1 |
| 4 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 5 | Th2 allergic immune re- sponse to inhaled fungal antigens is modulated by TLR-4-inde- pendent bacterial products 显示文摘 | Allard J B Rinaldi L Wargo M J | 2009 | Eur J Immunol2009，39，3： | 1 |
| 6 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole显示文摘 | Feres M Haffajee AD Allard K | 2001 | J Clin Periodontol2001，28，7： | 1 |
| 7 | Soluble HLA-I/peptide monomers mediate antigen-specific CD8 T cell activation through passive peptide exchange with cell-bound HLAq molecules 显示文摘 | Allard M Oger R Benlalam H | 2014 | J lmmunol2014，192，1： | 1 |
| 8 | Genetic diversity of Salmonella pathogenicity islands SPI-5 and SPI-6 in Salmonella Newport显示文摘 | Cao G Allard M Strain E Stones R Zhao S Brown E Meng J | 2014 | Foodborne Pathog Dis2014，11，10： | 1 |
| 9 | Removal of estrogenicity in Swedish municipal sewage treatment plants 显示文摘 | Svenson A Allard A S Ek M | 2003 | Water Res2003，37，18： | 1 |
| 10 | Removal of estrogenicity in Swedish municipal sewage treatment plants 显示文摘 | Svenson A Allard A S Ek M | 2003 | Water Res2003，37，12： | 1 |
| 11 | Effect of preoxidation on the nucleation an growth behavior of chemically vapor-de- posited a-A1203 on a single-crystal Ni-based superalloy 显示文摘 | He L M Su Y F Allard L F | 2004 | Metallurgical and Materials Transactions A2004，35，13： | 1 |
| 12 | Development of sediment quality values for Hong Kong Special Administrative Region:a possible model for other jurisdictions显示文摘 | Chapman P M Allard P J Vigers G A | 1999 | Marine Pollution Bulletin1999，38，3： | 1 |
| 13 | Bilateral gait patterns in subjects fitted with a total hip prosthesis显示文摘 | Loizeau J Allard P Duhaime M | 1995 | Arch Phys Med Rehabil1995，76，： | 1 |
| 14 | Nutrition Risk Factors for Survival in the Elderly Living in Canadian Long- term Care Facilities显示文摘 | Allard J P Aghdassi E McArthur M | 2004 | J Am Geriatr Soc2004，52，1： | 1 |
| 15 | Preeclampsia is associated with an increased pro-inflammatory profile in newbo rns显示文摘 | Guillemette L Lacroix M Allard C | 2015 | J Reprod Immunol2015，112，： | 1 |
| 16 | Rapid identification of rhizobia by restriction fragment length polyrnorplism analysis of PCR-amplified 16S rRNA genes显示文摘 | Laguerre G Allard M Revory F | 1994 | Appl Environ Microbiol1994，60，1： | 1 |
| 17 | The accuracy of noninvasive and continuous total hemoglobin measurement by pulse CO-Oximetry in human subjects undergoing hemodilution显示文摘 | MACKNET M R ALLARD M APPLEGATE R L 2nd | 2010 | Anesth Analg2010，111，6： | 1 |
| 18 | Serum soluble HLA-E in melanoma: a new potential immune-related marker in cancer显示文摘 | Allard M Oger R Vignard V | 2011 | PLoS One2011，6，21： | 1 |
| 19 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases显示文摘 | ALLARD W J MATERA J MILLER M C | 2004 | Clin Cancer Res2004，10，20： | 1 |
| 20 | Estima- tion of life cycle components of selection in an experi- mental plant population 显示文摘 | CLEGG M T KAHLER A L ALLARD R W | 1978 | Genetics1978，89，4： | 1 |
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