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| 1 | 睡眠不足导致警觉性降低而增强小鼠痛觉过敏显示文摘当代生活中,人们昼夜活动的不断增多导致睡眠缺乏的人群日益扩大,所以睡眠障碍像失眠症一样发病率较高。但是长期睡眠不足是怎样影响人们健康的,目前仍不是很明确。睡眠剥夺实验研究发现:如果睡眠质量和睡眠时间受到影响,第二天就可能出现疼痛症状,表明仅仅是睡眠障碍就有可能加剧疼痛。本文的研究发现,健康小鼠的睡眠不足(而不是睡眠片断化)可增加对伤害性刺激(即疼痛)的敏感性,而不是导致总体感觉的高反应性。中等程度的重复性睡眠不足,会导致睡眠不足的进行性累积和疼痛症状的进一步恶化,二者在恢复正常睡眠后都可以恢复到正常状态。两种促醒剂咖啡因(Caffeine)和莫达非尼(Modafinil),对睡眠充足的小鼠没有镇痛效果,却可快速恢复睡眠剥夺鼠的痛敏到正常痛阈水平,而不影响其睡眠不足的状态。促醒剂可减轻轻度睡眠不足诱发的疼痛,表明警觉性对痛觉过敏(痛敏)有一定的影响;本研究进一步表明,临床上睡眠不足或睡眠质量差可能会增加疼痛,这种痛敏可能对镇痛剂不敏感,但可通过提高警觉性或者改善睡眠得以缓解。 | Alexandre C Latremoliere A Ferreira A 张奉明 王兵 | 2018 | 中国疼痛医学杂志2018，24，3： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 4 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 5 | Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo显示文摘 | Alexandre J Batteux F Nicco C | 2006 | lnt J Cancer2006，119，1： | 1 |
| 6 | A study of two-dimensional microdischarge pattern formation in dielectric barrier discharges显示文摘 | Alexandre C Alexander G Alexander F | 2006 | Plasma Chemistry and Plasma Processing2006，26，2： | 1 |
| 7 | Molecular and morphologic characterization of a Cryptosporidium genotype identified in lemurs显示文摘 | Alexandre J Silva D Simone C | 2003 | Vet Parasitol2003，111，4： | 1 |
| 8 | The heterogeneous advantage:biodiesel by catalytic reactive distillation显示文摘 | KISS ANTON A FLORIN OMOTA DIMIAN ALEXANDRE C | 2006 | Topics in Catalysis2006，40，： | 1 |
| 9 | Roadmap for Developing Heat Pipes for ALCATEL SPACE's Satellites 显示文摘 | Hoa C Demolder B Alexandre A | 2003 | Applied Thermal Engineering2003，23，9： | 1 |
| 10 | Biodiesel by catalytic reactive distillation powered by metal oxides显示文摘 | KISS ANTON A DIMIAN ALEXANDRE C GADI ROTHENBERG | 2008 | Energy & Fuels2008，22，： | 1 |
| 11 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 12 | PI3K-FRAP/mTOR path-way is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival显示文摘 | Alexandre C Claude R David G | 2002 | Hepatology2002，3，： | 1 |
| 13 | Biological Applications of Rare-Earth Based Nanoparticles 显示文摘 | Bouzigues C Gacoin T Alexandrou A | 2011 | ACS Nano2011，5，11： | 1 |
| 14 | Biochemical aspects of stuck and sluggish fermentation in grape must 显示文摘 | Alexandre H Charpentier C | 1998 | Jour- nal of Industrial Microbiology & Biotechnology1998，20，1： | 1 |
| 15 | Pathophysiology of bone loss in disuse osteoporosis显示文摘 | Alexandre C Vico L | 2011 | Joint Bone Spine2011，78，6： | 1 |
| 16 | Spawning of turbot(Scophthalmus maximus) in captivity显示文摘 | Devauchelle N Alexandre J C Corre L E N | 1988 | Aquaculture1988，69，： | 1 |
| 17 | A review on the young history of the wind power short-term prediction显示文摘 | Alexandre C Antonio C Jorge N | 2008 | Renewable and Sustainable Energy Reviews2008，12，6： | 1 |
| 18 | Lymphatic system asa path underlying the spread of lung and gut injury after iniestinalisehemia/reperfusion in rats显示文摘 | Gabriela C Helori VD Alexandre LS | 2005 | Shock2005，23，4： | 1 |
| 19 | Preparation and properties of layered silicate nanocomposites based on ethylene vinyl acetate copolymers显示文摘 | ALEXANDRE M BEYER G HENRIST C | 2001 | Rapid Commun2001，22，： | 1 |
| 20 | Antioxidant and lipophilic constituents of tinosporacrispa 显示文摘 | Alexandre C K urt H Wahio D | 1998 | Planta Medica1998，64，： | 1 |
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