| 8 | MicroRNAs: New players in endometriosis显示文摘Endometriosis is an estrogen-dependent inflammatory disorder that limits the quality of life of affected women. This pathology affects 10% of reproductive-age women, although the prevalence in those patients experiencing pain, infertility or both is as high as 35%-50%. Endometriosis is characterized by endometrial-like tissue outside the uterus, primarily on the pelvic peritoneum, ovaries and the pouch of Douglas. Despite extensive research endeavours, a unifying theory regarding the exact etiopathogenic mechanism of this high prevalent and incapacitating condition is still lacking, although it has been suggested that epigenetics could be involved. Micro RNAs(mi RNAs), one of the epigenetic players, are small non-coding RNAs that can act as post-transcriptional regulators of gene expression, reducing the expression of their target m RNAs either inhibiting its translation or promoting its degradation. Mi RNA expression profiles are specific of tissue and cell type. Abnormal mi RNA expression has been described in different pathological conditions, such as a myriad of oncological, cardiovascular and inflammatory diseases and gynecological pathologies. In endometriosis, mi RNA expression patterns of eutopic endometrium from patients and control women and from different endometriotic lesions have been described. These small non-coding molecules have become attractive candidates as novel biomarkers for an early non-invasive diagnosis of the disease, which could suppose a valuable benefit to the patients in terms of improvement of prognosis and reduction of the ratio of recurrence. In this systematic review we will focus on the role of mi RNAs in the pathophisiology of endometriosis. | Josep Marí-Alexandre Moisés Barceló-Molina María Olcina-Guillem Javier García-Oms Aitana Braza-Bo?ls Juan Gilabert-Estellés | 2016 | World Journal of Obstetrics and Gynecology2016，5，1： | 0 |
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