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| 1 | Clinical and economic consequences of pancreatic fistula after elective pancreatic resection显示文摘BACKGROUND:Postoperative pancreatic fistula is the main cause of morbidity after pancreatic resection.This study aimed to quantify the clinical and economic consequences of pancreatic fistula in a medium-volume pancreatic surgery center.METHODS:Hospital records from patients who had undergone elective pancreatic resection in our department were identified.Pancreatic fistula was defined according to the International Study Group on Pancreatic Fistula(ISGPF).The consequences of pancreatic fistula were determined by treatment cost,hospital stay,and out-patient follow-up until the pancreatic fistula was completely healed.All costs of the treatment are calculated in Euros.The cost increase index was calculated for pancreatic fistula of grades A,B,and C as multiples of the total cost for the no fistula group.RESULTS:In 54 months,102 patients underwent elective pancreatic resections.Forty patients(39.2%) developed pancreatic fistula,and 54 patients(52.9%) had one or more complications.The median length of hospital stay for the no fistula,grades A,B,and C fistula groups was 12.5,14,20,and 59 days,respectively.The hospital stay of patients with fistula of grades B and C was significantly longer than that of patients with no fistula(P<0.001).The median total cost of the treatment was 4952,4679,8239,and 30 820 Euros in the no fistula,grades A,B,and C fistula groups,respectively.CONCLUSIONS:The grading recommended by the ISGPF is useful for comparing the clinical severity of fistula and for analyzing the clinical and economic consequences of pancreatic fistula.Pancreatic fistula prolongs the hospital stay and increases the cost of treatment in proportion to the severity of the fistula. | Filip Ceka Bohumil Jon Zdeněk ubrt Alexander Ferko | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 2 | Pancreatic Castleman disease treated with laparoscopic distal pancreatectomy显示文摘BACKGROUND: Castleman disease is an uncommon lympho-proliferative disorder most frequently occurring in the mediastinum. Abdominal forms are less frequent, with pancreatic localization of the disease in particular being extremely rare. Only seventeen cases have been described in the world literature. METHOD: This report describes an interesting and unusual case of pancreatic Castleman disease treated with laparoscopic resection. RESULTS: A 48-year-old woman presented with epigastric pain. CT scan showed a well-encapsulated mass on the ventral border of the pancreas. Endosonography with fine needle aspiration biopsy was performed. Biopsy showed lymphoid elements and structures of a normal lymph node. The patient was treated with laparoscopic distal pancreatectomy. The pancreas was transected with a Ligasure device and the pancreatic stump was secured with a manual suture. One year after surgery the patient was complaint-free and showed no signs of recurrence of the disease. CONCLUSIONS: Laparoscopic distal pancreatectomy is a feasible and safe method for the treatment of lesions in the body and tail of the pancreas. Transection of the pancreas with a Ligasure device offers the advantages of low bleeding and low risk of pancreatic fistula. | Filip ecka Alexander Ferko Bohumil Jon Zdeněk ubrt Petra Kaparová Rudolf Repák | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 4 |
| 3 | Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas显示文摘BACKGROUND:Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract;extragastrointestinal locations are extremely rare.Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported.None of the reports described a long-term follow-up of the patients.METHOD:This report describes an interesting and unusual case of GIST arising from the pancreas.RESULTS:A 74-year-old female presented with a palpable abdominal mass.CT scan showed a large mass 11×8×4 cm originating from the tail of the pancreas.Percutaneous biopsy revealed a GIST predominantly with spindle cells,but some parts also contained epitheloid cells.The patient was treated by distal pancreatic resection with splenectomy.Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST.The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease.CONCLUSION:This is the first reported case of an extragastrointestinal stromal tumor arising from the pancreas treated surgically,with a long-term survival. | Filip eka Bohumil Jon Alexander Ferko Zdeněk ubrt Dimitar H Nikolov Věra Tyová | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 3 |
| 4 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 5 | Surgical Technique in Distal Pancreatectomy: A Systematic Review of Randomized Trials显示文摘 | Filip ?e?ka Bohumil Jon Zdeněk ?ubrt Alexander Ferko Masahiko Hirota | 2014 | BioMed Research International2014，，： | 2 |
| 6 | Evaluation of methods of internal fixation of transverse patellar fractures: a biomechanical study显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | J Orthop Trauma1994，8，2： | 1 |
| 7 | Intranasal eosinophilic angiocentricfibrosis: a case report and review 显示文摘 | Sunde J Alexander KA Reddy VV | 2010 | Head Neck Pathol2010，4，3： | 1 |
| 8 | Evaluation of methods of internal fixation of transverse patella fractures: a biornechanical study显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | J Orthop Trauma1994，8，2： | 1 |
| 9 | Characterization of the calmodulin binding domain of neuromodulin functional significance of serine 41 and phenylalanine 42显示文摘 | Chapman ER Au D Alexander KA | 1991 | J Biol Chem1991，266，1： | 1 |
| 10 | Meta-analysis of animal fat or animal protein intake and colorectal cancer 显示文摘 | Alexander DD Cushing CA Lowe KA | 2009 | Am J Clin Nutr2009，89，5： | 1 |
| 11 | Evaluation of methods of internal fixation of transverse patella fractures: a biomechanical study 显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | Journal of Orthopaedic Trauma1994，8，： | 1 |
| 12 | Evaluation of methods of internal fixation of transverse patella fractures:a biomechanical study显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | J Orthop Trauma1994，8，2： | 1 |
| 13 | Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids显示文摘 | Alexander VM Roy M Steffens KA | 2010 | Int J Clin Exp Med2010，3，2： | 1 |
| 14 | RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells显示文摘 | Hall AH Alexander KA | 2003 | J Virol2003，77，： | 1 |
| 15 | Induction of cardiac INSulin-like growth factor 1 gene expression in pressure overload hypertrophy显示文摘 | Hanson MC Fath KA Alexander RW | 1993 | Am J Med Sci1993，306，： | 1 |
| 16 | Community outbreak of Mycoplasma pneumoniae infection:school-based cluster of neurologic disease associated with household transmission of respiratory illness显示文摘 | Walter ND Grant GB Bandy U Alexander NE Winchell JM Jordan HT Sejvar JJ Hicks LA Gifford DR Alexander NT Thurman KA Schwartz SB Dennehy PH Khetsuriani N Fields BS Dillon MT Erdman DD Whitney CG Moore MR | 2008 | J Infect Dis2008，198，8： | 1 |
| 17 | Assessment by meta - analysis of PCR for diagnosisof smear-negative pulmonary tuberculosis 显示文摘 | Samfiento OL Weigle KA Alexander J | 2003 | J ClinMicrobiol2003，41，7： | 1 |
| 18 | Evaluation of methods of intemalfixation of transverse patella fractures: a biomechanical study显示文摘 | Burvant JG Thonlas KA Alexander R | 1994 | J Orthop Trauma1994，8，： | 1 |
| 19 | Meta-analysis of animal fat or animal protein intake and colorectal cancer显示文摘 | Alexander DD Cushing CA Lowe KA | | 0，，5： | 1 |
| 20 | Evaluation of methods of internal fixation of transverse patellar fractures: a biomechanical study显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | J Orthop Trauma1994，8，2： | 1 |
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