|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 2 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 3 | How to make a good oocyte:an update on in vitro models to study follicle regulation显示文摘 | Thomas FH Walters KA Telfer EE | 2003 | Hum Reprod Update2003，9，6： | 1 |
| 4 | Effects of bone minerad density on pedicle screw fixation显示文摘 | Halvorson TL Kelley LA Thomas KA | 1994 | Spine1994，19，： | 1 |
| 5 | Fate of water soluble azo dyes in the activated sludge process显示文摘 | SHAUL Glenn M THOMAS J Holdsworth CLYDE R Dempsey Dostal KA | 1991 | Chemosphere1991，22，12： | 1 |
| 6 | Aggressive angiomyxoma:a distinct clinical entity显示文摘 | Behranwala KA Thomas JM | 2003 | Eur J Surg Oncol2003，29，7： | 1 |
| 7 | Acidic libroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat显示文摘 | Laird JM Mason GS Thomas KA Hargreaves RJ Hill RG | 1995 | Neuroscience1995，65，1： | 1 |
| 8 | Pressure volume characteristics of the intact and disrupted pelvic retroperitoneum 显示文摘 | Grimm MR Vrahas MS Thomas KA | 1998 | J Trauma1998，44，3： | 1 |
| 9 | Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers显示文摘 | Thomas DL Villano SA Riester KA | 1998 | J Infect Dis1998，177，6： | 1 |
| 10 | Evaluation of methods of internal fixation of transverse patellar fractures: a biomechanical study显示文摘 | Burvant JG Thomas KA Alexander R | 1994 | J Orthop Trauma1994，8，2： | 1 |
| 11 | The effects of simulated transverse, anterior column,and posterior column fractures of the acetabulum on the stability of the hip joint显示文摘 | Vrahas MS Widding KK Thomas KA | 1999 | J Bone Joint Surg Am1999，81，7： | 1 |
| 12 | Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotidc Modifier显示文摘 | Lennox KA Owczarzy R Thomas DM | 2013 | Mol Ther Nucleic Acids2013，2，： | 1 |
| 13 | The neurobiology of virtual reality pain attenuation显示文摘 | Gold JI Belmont KA Thomas DA | 2007 | Cyberpsychol Behav2007，10，4： | 1 |
| 14 | Aggressive angiomyxoma= a distinct clinical enty显示文摘 | Behranwala KA Thomas JM | 2003 | Eur J Surg Oneol2003，29，： | 1 |
| 15 | Evaluation of hip stability after simulated transvers acetabulum fractures 显示文摘 | Thomas KA Vrahas MS Nobel JW | 1997 | Clin Orthop Re- lat Res1997，，340： | 1 |
| 16 | The SMART-COP score performs well for pneumonia risk stratification in Australia′s Tropical Northern Territory:a prospective cohort study显示文摘 | Robins-Browne KL Cheng AC Thomas KA | 2012 | Trop Med Int Health2012，17，7： | 1 |
| 17 | A new stitch for llgament-ten- don fixation显示文摘 | Krackow KA Thomas SC Jones LC | 1986 | J Bone Joint Surg(Am)1986，68，： | 1 |
| 18 | MEHP/DEHP gonadal toxici- ty and effects on rodent accessory sec organs显示文摘 | Thomas JA Curto KA Thomas MJ | 1982 | Environ Health Perspect1982，45，： | 1 |
| 19 | Urothelial tissue culture for bladder reconstruction : an experimental study 显示文摘 | Hutton KA Trejdosiewicz LK Thomas DFM | 1993 | J Urol1993，150，： | 1 |
| 20 | L- Thyroxine activates Akt signaling in the heart显示文摘 | Kuzman JA Vogelsang KA Thomas TA | 2005 | J Mol Cell Cardiol2005，39，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员