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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Intensity of labor pain and cesarean delivery显示文摘 | Alexander JM Sharma SK Mclntire DD | 2001 | Anesth Analg2001，92，： | 1 |
| 3 | The course of labor with and without epidural anal-gesia显示文摘 | Alexander JM | 1998 | Am J Obstet Gynecol1998，178，3： | 1 |
| 4 | Efficacy of treatment for syphilis in pregnancy显示文摘 | Alexander JM Sheffield JS Sanchez PJ | 1999 | Obstet Gynecol1999，93，1： | 1 |
| 5 | Rates mad intensity of re-infection with human helminths after treatment and the influ- ence of individual, household, and environmental factors in a Brazilian community显示文摘 | Cundill B Alexander N Bethony JM | 2011 | Parasitology2011，138，11： | 1 |
| 6 | The bene? ts of peer collaboration on strategy use,metacognitive causal attribution,and recall显示文摘 | Manion V Alexander JM | | 0，，02： | 1 |
| 7 | Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice显示文摘 | Alexander JM Bab I Fish S Muller R Uchiyama T Gronowicz G Nahounou M Zhao Q White DW Chorev M Gazit D Rosenblatt M | | 0，，： | 1 |
| 8 | Effects of hyperoxia on bacteria translocation and mortality during gut-derived-sepsis显示文摘 | Gennart R Alexander JM | 1996 | Arch surg1996，131，： | 1 |
| 9 | Placenta accreta, increta, and percreta 显示文摘 | Wortman AC Alexander JM | 2013 | Obstet Gynecol Clin North Am2013，40，1： | 1 |
| 10 | Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma显示文摘 | Alexander HR Grem JL Hamilton JM | 1995 | Cancer J Sci Am1995，1，1： | 1 |
| 11 | Epidural analgesia during labor and maternal fever显示文摘 | Phillip J Alexander JM Sharma S | 1999 | Anesthesiology1999，90，9： | 1 |
| 12 | A tumor-specific truncated estrogen receptor splice variant enhances estrogen-stimulated gene expression显示文摘 | Chaidarun SS Alexander JM | 1998 | Mol Endocrinol1998，12，： | 1 |
| 13 | Effect of matrix metalloproteinases activity on outflow in perfused human organ culture显示文摘 | Bradley JM Vranka J Colvis CM Conger DM Alexander JP Fisk AS | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 14 | Risk of hepatitis B transmission after amniocentesis in chronic hepatitis B carriers显示文摘 | Alexander JM Ramus R Jackson G | | Infect Dis Obstet Gynecol0，7，6： | 1 |
| 15 | Epidural analgesia lengthens the Friedman active phase of labor显示文摘 | Alexander JM Sharma SK McIntire DD | 2002 | Obstet Gynecol2002，100，1： | 1 |
| 16 | Efficacy of treatment for syphilis in pregnancy显示文摘 | ALEXANDER JM SHEFFIELD JS SANCHEZ PJ | 1999 | Obstet Gynecol1999，93，： | 1 |
| 17 | Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility显示文摘 | Alexander BH Olsen GW Burris JM | 2003 | Oceup Environ Med2003，60，： | 1 |
| 18 | Differential expression of estrogen receptor-beta (ER beta) in human pituitary tumors:functional interactions with ER alpha and a tumor-specific splice variant显示文摘 | Chaidarun SS Swearingen B Alexander JM | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 19 | Patient perceptions of orthognathic surgery显示文摘 | Flanary CM Barnwell GM Jr Alexander JM | 1985 | Am J Orthod1985，88，2： | 1 |
| 20 | severe pre-eclampsia and the very low brith weight infant: Is induction of labor harmful? 显示文摘 | Alexander JM Bloom SL MCIntire DD | 1999 | Obstet Gynecol1999，93，： | 1 |
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