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| 1 | Human biofield therapy does not affect tumor size but modulates immune responses in a mouse model for breast cancer显示文摘OBJECTIVE:To assess the effect of human biofield therapy, an integrative medicine modality, on the development of tumors and metastasis, and immune function in a mouse breast cancer model. METHODS: Mice were injected with 66cl4 mammary carcinoma cells. In study one, mice received biofield therapy after cell injection. In study two, mice were treated by the biofield practitioner only prior to cell injection. Both studies had two control groups of mock biofield treatments and phosphatebuffered saline injection. Mice were weighed and tumor volume was determined. Blood samples were collected and 32 serum cytokine/chemokine markers were measured. Spleens/popliteal lymph nodes were isolated and dissociated for fluorescent-activated cell sorting(FACS) analysis of immune cells or metastasis assays in cell culture.RESULTS: No significant differences were found in weight, tumor size or metastasis. Significant effects were found in the immune responses in study one but no additional effects were found in study two. In study one, human biofield treatment significantly reduced percentage of CD4^+CD44lo CD25^+ and percentage of CD8^+ cells, elevated by cancer in the lymph nodes, to control levels determined by FACS analysis. In the spleen, only CD11b^+ macrophages were increased with cancer, and human biofield therapy significantly reduced them. Of 11 cytokines elevated by cancer, only interferon-g, interleukin-1, monokine induced by interferon-g, interleukin-2 and macrophage inflammatory protein-2 were significantly reduced to control levels with human biofield therapy.CONCLUSION: Human biofield therapy had no significant effect on tumor size or metastasis but produced significant effects on immune responses apparent in the down-regulation of specific lymphocytes and serum cytokines in a mouse breast cancer model. | Gloria Gronowicz Eric R.Secor Jr. John R.Flynn Liisa T.Kuhn | 2016 | Journal of Integrative Medicine2016，14，5： | 3 |
| 2 | Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro显示文摘 | Gohel A McCarthy MB Gronowicz G | 1999 | Endocrinology1999，140，： | 2 |
| 3 | Aseorbic acid alters collagen integrins in bone euhure 显示文摘 | Ganta DR McCarthy MB Gronowicz GA | 1997 | Endocrinology1997，138，9： | 1 |
| 4 | Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice显示文摘 | Alexander JM Bab I Fish S Muller R Uchiyama T Gronowicz G Nahounou M Zhao Q White DW Chorev M Gazit D Rosenblatt M | | 0，，： | 1 |
| 5 | Integrin-mediated signaling in osteoblasts on titanium implant materials显示文摘 | KRAUSE A COWLES E A GRONOWICZ G | 2000 | J Biomedical Materials Research2000，52，4： | 1 |
| 6 | Transforming growth factor-beta 1 (TGF-β1) prevents the age-dependent decrease in bone formation in human osteoblast/implant cultures显示文摘 | Zhang H Aronow MS Gronowicz GA | 2005 | J Biomed Mater Res2005，75，1： | 1 |
| 7 | Functionalized silk-based biomaterials for bone formation显示文摘 | Sofia S McCarthy M B Gronowicz G | 2001 | J Biomed Mater Res2001，54，1： | 1 |
| 8 | Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts显示文摘 | Cowles EA Brailey LL Gronowicz GA | 2000 | J Biomed Mater Res2000，52，4： | 1 |
| 9 | Functionalized silk - based biomaterials for bone formation显示文摘 | Sofia S McCarthy MB Gronowicz G | 2001 | J Biomed Mater Res2001，54，1： | 1 |
| 10 | Estrogen prevents glucoeorticoid-induced apoptosis in osteoblasts in vivo and in vitro显示文摘 | Gohel A McCarthy M B Gronowicz G | 1999 | Endocrinology1999，140，11： | 1 |
| 11 | Funetionalized silk-based biomaterials for bone formation显示文摘 | SOFIA S MCCARTHY M B GRONOWICZ G | 2001 | J Biomed Mater Res2001，54，1： | 1 |
| 12 | Functionalized silk-based biomaterials for bone formation 显示文摘 | Sofia S McCarthy M B Gronowicz G | 2001 | J Biomed Mater Res A2001，54，1： | 1 |
| 13 | Functionalized silk-based biomaterials for bone formation显示文摘 | Sofia S McCarthy M B Gronowicz G | 2000 | J Biomed Mater Res2000，54，1： | 1 |
| 14 | 显示文摘 | Sofia S McCarthy M B Gronowicz G | 2001 | J Biomed Mater Res2001，54，： | 1 |
| 15 | Prostaglandin E2 stimulates preosteoblast replication: an autoradiographic study in cultured fetal rat calvariae显示文摘 | Gronowicz GA Fall PM Raisz LG | 1994 | Exp Cell Res1994，212，3： | 1 |
| 16 | Maturation of the reticulocyte in vitro显示文摘 | Gronowicz G Swift H Steck T L | 1984 | J Cell Sci1984，71，1： | 1 |
| 17 | Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts 显示文摘 | Cowles EA Brailey LL Gronowicz GA | 2000 | J Biomed Mater Res2000，52，4： | 1 |
| 18 | Effect of platelet-rich plasma with autogenous bone graft for sinus augmentation in a rabbit model显示文摘 | Butterfield KJ Bennett J Gronowicz G | 2005 | J Oral Maxillofac Surg2005，63，3： | 1 |
| 19 | An in vitro model for mineralization of human osteoblast-like cells on implant materials 显示文摘 | Ahmad M McCarthy MB Gronowicz G | 1999 | Biomaterials1999，20，3： | 1 |
| 20 | Immunogold localization of beta 1-integrin in bone: effect of glucocorticoids and insu- lin-like growth factor I on integrins and osteocyte forma- tion 显示文摘 | Gohel AR Hand AR Gronowicz GA | 1995 | J Histochem Cytochena1995，43，11： | 1 |
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