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6篇 您的检索式:作者名="Alexander FM"
    题名 作者 年代 出处 被引量
1Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery.Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen 2008World Journal of Gastroenterology2008,14,45:4
2Loss of HLA haplotype and B locus down-regulation in melanoma cell lines 显示文摘Marincola FM Shamamian P Alexander RB 1994J Immunol1994,153,3:1
3Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization显示文摘This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed after 6 mo. Macro- and microscopic examination showed complete necrosis and absence of tumorous tissue. The patient was discharged without complications, and subsequent follow-up until 22 mo after resection did not reveal any new lesions in the liver. This case emphasizes the signifi cance of selective arterial embolization in the management of bleeding liver tumors and questions the need for (partial) hepatectomy after this procedure in selective cases.Volkert AL Huurman Jan HMB Stoot Edwin van der Linden Alexander F M Schaapherder Onno T Terpstra Alexander FM Schaapherder 2006World Journal of Gastroenterology2006,12,37:1
4Recent advances in the diagnosis of acute aortic syndromes显示文摘Rolf Alexander Jánosi Raimund Erbel Thomas FM Konorza 2012Expert Opinion on Medical Diagnostics2012,,6:1
5Genomic analysis of human multigene families using chromosome-specific vectorette PCR显示文摘Terry PM Alexander FM Philip AR 1996Nucl Acids Res1996,24,:1
6p38 mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin显示文摘Yahio FM Alexander RW Akers M 1998J Biol Chem1998,273,15:1
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