4篇
您的检索式：作者名="Alex Soltermann"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relevance of Periostin Splice Variants in Renal Cell Carcinoma显示文摘 | Laura Morra Markus Rechsteiner Silvia Casagrande Van Duc Luu Roger Santimaria Pierre A. Diener Tullio Sulser Glen Kristiansen Peter Schraml Holger Moch Alex Soltermann | 2011 | The American Journal of Pathology2011，，3： | 1 |
| 2 | Impact of p16,p53,smoking,and alcohol on survival in patients with oropharyngeal squamous cell carcinoma treated with primary intensity-modulated chemoradiation显示文摘 | Martina A Broglie Alex Soltermann David | 2013 | Head & Neck2013，35，12： | 1 |
| 3 | SOX2 amplification is a common event in squamous cell carcinomas of different organ sites显示文摘 | Sebastian Maier Theresia Wilbertz Martin Braun Veit Scheble Markus Reischl Ralf Mikut Roopika Menon Pavel Nikolov Karen Petersen Christine Beschorner Holger Moch Christoph Kakies Chris Protzel Jürgen Bauer Alex Soltermann Falko Fend Annette Staebler Claud | 2011 | Human Pathology2011，，8： | 1 |
| 4 | Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections显示文摘Because of the close interaction between tumors and the immune system,immunotherapies are nowadays considered as the most promising treatment against cancer.In order to define the diagnosis and the subsequent therapy,crucial information about the immune cells at the tumor site is needed.Indeed,different types or activation status of cells may be indicative for specific and personalized treatments.Here,we present a quantitative method to identify ten different immuno-markers in the same tumor cut section,thereby saving precious samples and enabling correlative analysis on several cell families and their activation status in a tumor microenvironment context.We designed and fabricated a microfluidic chip with optimal thermomechanical and optical properties for fast delivery of reagents on tissue slides and for fully automatic imaging by integration with an optical microscope.The multiplexing capability of the system is enabled by an optimized cyclic immunofluorescence protocol,with which we demonstrated quantitative sequential immunostaining of up to ten biomarkers on the same tissue section.Furthermore,we developed high-quality image-processing algorithms to map each cell in the entire tissue.As proofof-concept analyses,we identified coexpression and colocalization patterns of biomarkers to classify the immune cells and their activation status.Thanks to the quantitativeness and the automation of both the experimental and analytical methods,we believe that this multiplexing approach will meet the increasing clinical need of personalized diagnostics and therapy in cancer pathology. | Daniel Migliozzi Benjamin Pelz Diego G.Dupouy Anne-Laure Leblond Alex Soltermann Martin A.M.Gijs | 2019 | Microsystems & Nanoengineering2019，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员