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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Assessment of protection system positioning and models using observations of lightning strikes to structures显示文摘 | Petrov N I D' Alessandro F | 2002 | Proceedings of Royal Society Lond A2002，458，1： | 1 |
| 3 | Idarubicin and cytosine arabinoside in the induction and maintenance therapy of high-risk myelodysplastic syndromes 显示文摘 | Rosangela I Alessandro P Giuseppe R | 1997 | Haematology1997，82，： | 1 |
| 4 | Online optimization of swimming and crawling in an amphibious snake robot显示文摘 | ALESSANDRO C AUKE J I | 2008 | IEEE Transaction on Robotics2008，24，1： | 1 |
| 5 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D~Alessandro F | 2003 | IEEE Transactions on Dielertrics and Electrical Insulation2003，10，4： | 1 |
| 6 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D'Alessandro F | | 0，，04： | 1 |
| 7 | Monitoring landslides from optical remotely sensed imagery: the case history of Tessina landslide, Italy显示文摘 | Javier Hervás José I Barredo Paul L Rosin Alessandro Pasuto Franco Mantovani Sandro Silvano | 2003 | Geomorphology2003，，1： | 1 |
| 8 | Busi- ness incubators and new venture creation: an assessment of incubating models显示文摘 | ROSA GR IMALD I ALESSANDRO GRAND I | 2005 | Technovation2005，25，2： | 1 |
| 9 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N Alessandro F D | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，4： | 1 |
| 10 | Phase II study of a single pegfilgrastim injection as an adjunct to chemotherapy to mobilize stem cells into the peripheral blood of pretreated lymphoma patients显示文摘 | Alessandro I Monica T Francesca B | 2005 | Haematologica2005，90，2： | 1 |
| 11 | Z-Score Models' Applica-tion to Italian Companies Subject to Extraordinary Administration显示文摘 | A Edward I D Alessandro F Alberto | 2013 | Journal of Applied Finance2013，23，1： | 1 |
| 12 | Quantification of the Probability of Lightning Strikes to Structures Using a Fractal Approach显示文摘 | PETROV N I PETROVA G N ALESSANDRO F D | | 0，，04： | 1 |
| 13 | Microsurgical endoscopy-assisted presigrnoid retrolabyrinthine approach as a minimally invasive surgical option for the treatment of medium to large vestibular schwannomas显示文摘 | Maurizio I Fabrizio S Alessandro DR | 2013 | Acta Neuroehirurgica2013，155，4： | 1 |
| 14 | Theoretical analysis of the processes involved in lightning attachment to earthed structures显示文摘 | Petrov N I Alessandro F D | 2002 | Journal of Physics D:Applied Physics2002，，35： | 1 |
| 15 | REST: an oncogene or a tumor suppressor显示文摘 | Negrini S Prada I D'Alessandro R | 2013 | Trends Cell Biol2013，23，6： | 1 |
| 16 | An ultrasound technique for 3D palmprint extraction显示文摘 | Antonio I Alessandro S S Giosue C | 2014 | Sensors and Actuators A:Physical2014，212，： | 1 |
| 17 | Comparing air quality in Italy,Germany mad Poland using BC indexes显示文摘 | OLHA BODNAR MICHELA CAMELETI'I ALESSANDRO FASSO | 2008 | Atmospheric Environment2008，42，： | 1 |
| 18 | Zinc,antioxidant systems and metallothionein in metal mediated-apoptosis:biochemical and cytochemical aspects显示文摘 | Alessla F Paola I Alessandro S | 2007 | Comp Biochem Physiol C Toxicol Pharmacot2007，146，4： | 1 |
| 19 | Quantification of the probability of lightning strikes to structures using a fractal approaeh显示文摘 | Petrov N I Petrova G N D' Alessandro F | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，4： | 1 |
| 20 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N Alessandro F D | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，4： | 1 |
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