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| 1 | Factors affecting breastfeeding duration in Greece:What is important?显示文摘AIM:To investigate factors associated with breastfeeding duration(BD) in a sample of mothers living in Greece.METHODS:Four hundred and twenty-eight mothers(438 infants) were initially recruited in a tertiary University Hospital.Monthly telephone interviews(1665in total) using a structured questionnaire(one for each infant) were conducted until the sixth postpartum month.Cox regression analysis was used to assess factors influencing any BD.RESULTS:Any breastfeeding rates in the first,third,and sixth month of the infant's life reached 87.5%,57.0%and 38.75%,respectively.In the multivariate analysis,maternal smoking in the lactation period[hazard-ratio(HR) = 4.20]and psychological status(HR = 1.72),and the introduction of a pacifier(HR =2.08),were inversely associated,while higher maternal education(HR_(university/college vs primary/high school) = 0.53,HR_(master's vs primary/high school) = 0.20),and being an immigrant(HR = 0.35) were positively associated with BD.CONCLUSION:Public health interventions should focus on campaigns against smoking during lactation,target women of lower educational status,and endorse the delayed introduction of pacifiers. | Evangelia-Filothei Tavoulari Vassiliki Benetou Petros V Vlastarakos Theodora Psaltopoulou George Chrousos George Kreatsas Alexandras Gryparis Athena Linos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 12 |
| 2 | NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease显示文摘AIM: To assess whether the polymorphisms of NOD2/ CARD15 , autophagy-related 16-like 1 (ATG16L1 ), and interleukin-23 receptor (IL23R ) genes play a more critical role in the susceptibility of childhood-onset than in adult-onset Crohn’s disease (CD). METHODS: Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 ; rs2241880 A/G of ATG16L1 , and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. Analysis of polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 genotyping was performed by allele specific polymerase chain reaction (PCR) or by PCR-restriction fragment length polymor-phism analysis. The polymorphisms rs2241880 A/G of the ATG16L1 , and rs11209026 (R381Q) of the IL23R gene in the children’s cohort were genotyped by PCR and melting curve analysis whereas adult group genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 5.0 (500K). RESULTS: The 3020insC allele in NOD2/CARD15 was significantly higher in childhood than in adult-onset CD (P = 0.0067). Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without co- lonic involvement). Even if the frequency of G allele of the rs2241880 ATG16L1 polymorphism was increased in both paediatric and adult CD patients compared to con- trols (P = 0.017 and P = 0.001, respectively), no difference was observed between the childhood and the adult cohort. The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. The presence of the rs2241880 ATG16L1 and rs11209026 IL23R polymorphisms did not influence disease phenotype. CONCLUSION: Polymorphism 3020insC in NOD2/ CARD15 occurs statistically significantly more often in patients with childhood-onset CD than in patients with adult-onset CD. The ATG16L1 and IL23R variants are associated with susceptibility to CD, but not earlyonset disease. | Maria Gazouli Ioanna Pachoula Ioanna Panayotou Gerassimos Mantzaris George Chrousos Nicholas P Anagnou Eleftheria Roma-Giannikou | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 3 | Glucocorticoids and their actions: an introduction显示文摘 | Charmandari E Kino T Chrousos G P | 2004 | Arm N Y Acad Sci2004，1024，： | 1 |
| 4 | The concept of stress and stress system disorders显示文摘 | Chrousos GP God PW | 1992 | JAMA1992，267，9： | 1 |
| 5 | Glucocorticoid receptor β:iewⅠ显示文摘 | Alessandra V George P Chrousos | 1999 | TEM1999，10，8： | 1 |
| 6 | The stress response and immune function : Clinical implications 显示文摘 | CHROUSOS G P | 2000 | Ann NY Aead Sei2000，917，： | 1 |
| 7 | Sleep, the hypothalamic pituitary adrenal axis and cytokines : multiple interactions and disturbances insleep disorders 显示文摘 | Vgontzas AN Chrousos GP | 2002 | Endorinol Metab Clin North Am2002，31，1： | 1 |
| 8 | Assisted reproduction and its neuroendocrine impact on the offspring显示文摘 | Kanaka-Gantenbein C Sakka S Chrousos GP | 2010 | Prog Brain Res2010，182，： | 1 |
| 9 | Sleep apnea is a manifes- tation of the metabolic syndrome显示文摘 | Vgontzas AN Bixler EO Chrousos GP | 2005 | Sleep Med Rev2005，9，3： | 1 |
| 10 | Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster:potential physiological implications显示文摘 | Nader N Chrousos G P Kino T | 2009 | FASEB J2009，23，5： | 1 |
| 11 | The concept of stress and stress system disorders 显示文摘 | Chrousos G P Gold P W | 1992 | JAMA1992，267，9： | 1 |
| 12 | Human glucocorticoid receptor isoform p: recent understanding of its potential implications in physiology and pathophysiology显示文摘 | Kino T Su Y A Chrousos G P | 2009 | Cellular and Molecular Life Sciences2009，66，： | 1 |
| 13 | Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy显示文摘 | Meduri GU Annane D Chrousos GP | 2009 | Chest2009，136，6： | 1 |
| 14 | Adrenal insufficiency显示文摘 | Charmandari E Nicolaides NC Chrousos GP | 2014 | Lancet2014，383，9935： | 1 |
| 15 | Interactions of the circadian CLOCK system and the HPA axis显示文摘 | Nader N Chrousos G P Kino T | 2010 | Trends Endocrinol Metab2010，21，5： | 1 |
| 16 | Aerobic Exercise Training Improves Insulin Sentivity Without Changes in Body Weight,Body Fat,Adiponectin,and Inflammatory Markers in Overweight and Obese Girls显示文摘 | Yannakoulia M Chrousos GP Sidossis LS | 2005 | Metabolism2005，54，11： | 1 |
| 17 | The hypothalamic-pituitary-adrenal axis and immune- mediated inflammation 显示文摘 | Chrousos GP | 1995 | N Engl J Med1995，332，20： | 1 |
| 18 | The Sympathetic Nerve-an Integrative Interface between Two Supersystems: The Brain and the Immune System显示文摘 | ELENKOV I J WILDER R L CHROUSOS G P | 2000 | Pharmacol Rev2000，52，： | 1 |
| 19 | Physiology of the hypothalamic-pituitary-adrenal axis in health and dysregulation in psychiatric and autoimmune disorders显示文摘 | Tsigos C Chrousos GP | | 0，，03： | 1 |
| 20 | Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man显示文摘 | Charmandari E Chrousos G P Lambrou G I | 2011 | PLoS One2011，6，25： | 1 |
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