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| 1 | Post-traumatic hepatic artery pseudoaneurysm treated with endovascular embolization and thrombin injection显示文摘Post-traumatic hepatic artery pseudoaneurysm is unc-ommon,appearing in approximately 1%of hepatic trauma cases.Most are extrahepatic(80%)and have a late onset.Although they are usually asymptomatic, they should always be treated becasue of the high risk of complications,especially breakage.Currently the treatment of choice is endovascular embolization with coils or the exclusion of the pseudoaneurysm using other intravascular devices.Recently there have been accounts of a treatment that combines embolization with coils and image-guided percutaneous human thrombin injection.We present a case of post-traumatichepatic artery pseudoaneurysm that was successfully treated using this combined technique. | Lloret Esta Francisco López Conesa Asunción Capel Alemán Antonio Robles Campos Ricardo Reus Pintado Manuel Marín Hernández Caridad | 2010 | World Journal of Hepatology2010，2，2： | 9 |
| 2 | Porous media grain size distribution and hydrodynamic forces effects on transport and deposition of suspended particles显示文摘The effects of porous media grain size distribution on the transport and deposition of polydisperse suspended particles under different flow velocities were investigated. Selected Kaolinite particles(2–30 μm) and Fluorescein(dissolved tracer) were injected in the porous media by step input injection technique. Three sands filled columns were used: Fine sand,Coarse sand, and a third sand(Mixture) obtained by mixing the two last sands in equal weight proportion. The porous media performance on the particle removal was evaluated by analysing particles breakthrough curves, hydro-dispersive parameters determined using the analytical solution of convection–dispersion equation with a first order deposition kinetics, particles deposition profiles, and particle-size distribution of the recovered and the deposited particles. The deposition kinetics and the longitudinal hydrodynamic dispersion coefficients are controlled by the porous media grain size distribution. Mixture sand is more dispersive than Fine and Coarse sands. More the uniformity coefficient of the porous medium is large, higher is the filtration efficiency. At low velocities, porous media capture all sizes of suspended particles injected with larger ones mainly captured at the entrance.A high flow velocity carries the particles deeper into the porous media, producing more gradual changes in the deposition profile. The median diameter of the deposited particles at different depth increases with flow velocity. The large grain size distribution leads to build narrow pores enhancing the deposition of the particles by straining. | Nasre-Dine Ahfir Ahmed Hammadi Abdellah Alem HuaQing Wang Gilbert Le Bras Tariq Ouahbi | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
| 3 | A comparative assessment on regeneration status of indigenous woody plants in Eucalyptus grandis plantation and adjacent natural forest显示文摘差异,密度和在桉树类下面的自然地改革的木本植物的种类作文宏大种植园和邻近的自然森林被调查并且比较。二十个阴谋,与 20 m ×的一个区域为各个的 20 m, E 在两个被建立。宏大独立地是种植园和邻近的自然森林。在每个阴谋,种类名字,丰富,直径和高度被记录。幼苗的数字在五次要情节被收集(在每个主要阴谋以内的 4 m 2) 。在种植园的 46 种类的一个总数,和自然森林里的 52 种类,它属于 36 个家庭被记录。种类(H′) 的差异在种植园是 2.19 并且 2.74 在自然森林里。密度在故事下面,木本植物在自然森林里是在种植园和 4122 stems/ha 的 3842 stems/ha。自然森林和种植园里的幼苗的密度分别地是 8101 stems/ha 和 4151 stems/ha。木质的种类作文的高类似在自然森林和种植园之间被发现。E。宏大种植园被发现比另外的在下面木质的种类以一个好一些的方法赞成 Millitia ferruginia 和 Coffea 阿拉伯咖啡的新生和生长。 | Shiferaw Alem Tadesse Woldemariam | 2009 | Journal of Forestry Research2009，20，1： | 4 |
| 4 | 巨桉(Eucalyptus grandis)植被和其相邻的山地雨林中土壤营养的评价(英文)显示文摘研究评价巨桉(Eucalyptus grandis)植被和其相邻的山地雨林中土壤营养状况。在研究地建立了20个样方,每个小样方为20mx20m。在每个小样方内对土壤进行5个样点的采样(4角和中心点)。把每个小样方的不同点采集的土样进行混合,并独立放置。分析结果表明,巨桉植被和其相邻的山地雨林中土壤指标(全N、有效P、可交换性K、Ca和Mg含量),pH值以及全碳含量)没有明显的变化。但两种林地土壤中的粘土颗粒和可交换性N含量有明显的变化。与巨桉植被相邻的山地雨林中土壤指标比较表明,巨桉植被有提高土壤营养和全碳含量的作用。 | Shiferaw Alem Tadesse Woldemariam Jindrich Pavlis | 2010 | Journal of Forestry Research2010，21，4： | 3 |
| 5 | Liver steatosis in hepatitis C patients显示文摘There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in 'pure' steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients. | Emilio González-Reimers Geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 6 | Mechanisms of Obesity-induced Gastrointestinal Neoplasia显示文摘 | José O. Alemán Leonardo H. Eusebi Luigi Ricciardiello Kavish Patidar Arun J. Sanyal Peter R. Holt | 2013 | Gastroenterology2013，，： | 3 |
| 7 | Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C显示文摘AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration (< 400 000 vs ≥ 400 000), genotype (1/4 vs 3/4), cirrhotic status and ribavirin dose (800/1000/1200 mg/d).RESULTS: A total of 1014 patients were included in the study. Mean age of the patients was 44.3 ± 9.8 years, 70% were male, and 97% were Caucasian. The main sources of HCV infection were intravenous drug abuse (25%) and blood transfusion (23%). Seventyeight percent were infected with HCV genotype 1/4 (68% had genotype 1) and 22% with genotypes 2/3. The HCV-RNA level was > 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%). The planned treatment duration was 48 wk for 92% of patients with genotype 2/3 and 24 wk for 97% of those with genotype 1/4 (P < 0.001). Seven percent of patients experienced at least one reduction in ribavirin or peginterferon α-2a dose, respectively. Only 2% of patients required a dose reduction of both drugs. Treatment was continued until week 12 in 99% of patients. Treatment compliance was ≥ 80% in 98% of patients. EVR was achieved in 87% of cases (96% vs 83% of patients with genotype 2/3 and 1/4, respectively; P < 0.001). The bivariate analysis showed that patients who failed to achieve EVR were older (P < 0.005), had higher ALT (P < 0.05), AST (P < 0.05), GGT (P < 0.001) and ferritin levels (P < 0.001), a diagnosis of cirrhosis (P < 0.001), and a higher baseline viral load (P < 0.05) than patients reaching an EVR. Age < 40 years [odds ratios (OR): 0.543, 95%CI: 0.373-0.790, P < 0.01], GGT < 85 IU/mL (OR: 3.301, 95%CI: 0.192-0.471, P < 0.001), low ferritin levels (OR: 0.999, 95%CI: 0.998-0.999, P < 0.01) and genotype other than 1/4 (OR: 4.716, 95%CI: 2.010-11.063, P < 0.001) were identified as independent predictors for EVR in the multivariate analysis. CONCLUSION: CHC patients treated with peginterferon-α-2a/ribavirin in clinical practice show high EVR. Older age, genotype 1/4, and high GGT were associated with lack of EVR. | Javier García-Samaniego Miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 8 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 9 | Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties显示文摘 | Mhamed Ramchoun Hicham Harnafi Chakib Alem Berthold Büchele Thomas Simmet Mustapha Rouis Fouad Atmani Souliman Amrani | 2012 | e-SPEN Journal2012，，3： | 2 |
| 10 | β_2-AR激动剂BI-167107的合成显示文摘BI-167107是一种新的长效β2肾上腺素受体(β2-AR)激动剂,在鉴定G蛋白偶联受体(GPCR)/配体络合物的结构方面具有重要应用.以2-硝基间苯二酚为原料,经过七步反应,合成了目标化合物,其结构经1H NMR,13C NMR和MS确证.此合成路线的优点是避免了使用有毒试剂,可以便捷地用于制备较大量的BI-167107及结构相近的苯并噁嗪类化合物. | 王江波 Seungkirl Ahn Alem W.Kahsai 刘蓉 任杰 胡昆 孙小强 陈新 | 2013 | 有机化学2013，33，3： | 2 |
| 11 | S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism显示文摘AIM:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(AdoMet).METHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DMSO or 4 mmol/L AdoMet and thenexposed to 100 mmo/L ethanol.Hepatocyte apoptosiswas determined by the TUNEL and DNA ladder assays.JNK activity and its inhibition by SP600125 and AdoMetwere determined by Western blot analysis of c-junphosphorylation and Bid fragmentation.SP600125 andAdoMet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 fragmentation.The AdoMeteffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell cytometry.RESULTS:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(P<0.05).AdoMet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by ethanol.JNK activation may be independentfrom ROS generation,since AdoMet which exertedantioxidant properties did not have a significant effect onJNK activity.JNK pathway modulator agents and AdoMetmay be components of promising therapies for alcoholicliver disease(ALD)treatment. | Maria del Pilar Cabrales-Romero Lucrecia Márquez-Rosado Samia FatteI-Fazenda Cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 12 | Titania ultrafihration membrane:preparation,characterization and photocatalytic activity显示文摘 | ALEM A SARPOOLAKY H KESHMIRI M | 2009 | Journal of the European Ceramic Society2009，29，4： | 1 |
| 13 | Graphs for the design of laterally loaded piles in clay显示文摘 | Abdellah Alem Ahmed Benamar | 2002 | The Electronic Journal of Geotechnical Engineering2002，，： | 1 |
| 14 | Increased risk of hip fracture among patients with end-stage renal disease 显示文摘 | Alem AM Sherrard DJ Gillen DL | 2000 | Kidney Int2000，58，1： | 1 |
| 15 | Acupuncture in the rehabilitation of women after breast cancer surgery-a case series显示文摘 | Alem M Gurgel MS | | 0，，02： | 1 |
| 16 | Contribution ofLeu and Hyp residues to antioxidant and ACE-inhibitory activi-ties of peptide sequences isolated from squid gelatin hydrolysate显示文摘 | Alemán A Giménez B Pérez-Santin E | 2011 | Food Chem2011，125，2： | 1 |
| 17 | Filtration of kaolinite particles in a saturated porous medium: hydrodynamic effects显示文摘 | Abdellah Alem Abdulghadir Elkawafi Nasre-Dine Ahfir HuaQing Wang | 2013 | Hydrogeology Journal2013，，3： | 1 |
| 18 | Utility of the concept of minor depressive disorder:Evidence from a large rural community sample in a developing country setting显示文摘 | Fekadu A Alem A Medhin G | 2007 | J Affective Diserderg2007，104，： | 1 |
| 19 | Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development显示文摘 | Alem MA Oteef MD Flowers TH | | 0，，10： | 1 |
| 20 | Utilization,Predictability,Workloads, and User Runtime Estimates in Scheduling the IBM SP2 with Backfilling 显示文摘 | A W Mu'alem D G Feitelson | 2001 | IEEE Trans on Parallel and Distributed System2001，12，6： | 1 |
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