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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Carbon nanotubes as reinforcement of styrene-butadiene rubber 显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Surface Science2007，254，1： | 1 |
| 3 | Phosphorylation of extra-nuclear ERK/MAPK is required for long-term memory consolidation in the crab Chasmagnathus 显示文摘 | Mariana F Beatriz D Alejandro D | 2005 | Behav Brain Res2005，158，2： | 1 |
| 4 | Essence of kernel Fisher discriminant: KPCA plus LDA 显示文摘 | Yang J Jin Z Yang J Y Zhang D Alejandro F F | 2004 | Pattern Recognition2004，37，： | 1 |
| 5 | Two-dimensional PCA: A new approach to appearance-based face representation and recognition显示文摘 | Yang Jian Zhang D Alejandro F | 2004 | IEEE Transactions on PAMI2004，26，1： | 1 |
| 6 | Phosphorylation of extranuclear MAPK is required for long-term memory consolidation in the crab Chasmagnathus显示文摘 | Mariana F Beatriz D Alejandro D | 2005 | Behavioural Brain Res2005，158，2： | 1 |
| 7 | Carbon nanotubes as reinforcement of styrene-butadiene rubber显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Sur- face Science2007，254，1： | 1 |
| 8 | Two-Di- mensional PCA: A new approach to appearance-based face representation and recognition 显示文摘 | YANG J ZHANG D ALEJANDRO F | 2004 | IEEE Trans on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 9 | Two-dimensional PCA: a new approach to appearance-based face representation and recognition显示文摘 | Yang J Zhang D Alejandro F | 2004 | IEEE Transaction on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 10 | Haar-Iikefeatures with optimally weighted rectangles for rapid object detec-tion显示文摘 | SRI-KAUSHIK P DAVID D ALEJANDRO F F | 2010 | Pattern Recognition2010，43，1： | 1 |
| 11 | Phosphorylation of extranuelear ERK/MAPK is required for long term memory consoli dation in the crab Chasmagnathus显示文摘 | MARIANA F BEATRIZ D ALEJANDRO D | 2005 | Behavioural Brain Res2005，158，2： | 1 |
| 12 | Phosphorylation of extranuclear ERK/MAPK is required for long-term memory consolidation in the crab Chasmagnathus显示文摘 | Mariana F Beatriz D Alejandro D | 2005 | Behav Brain Res2005，158，2： | 1 |
| 13 | Two-Dimensional PCA : A New Approach to Appearance-Based Face Representationand Recognition 显示文摘 | Yang J Zhang D Alejandro F F | 2004 | IEEE Trans on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 14 | Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy显示文摘The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy. | Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner David L Horn | 2017 | World Journal of Stem Cells2017，9，3： | 1 |
| 15 | Two-dimensional PCA: a new approach to appearance-based face representation and recognition显示文摘 | YANG Jian ZHANG D ALEJANDRO F | 2004 | IEEE Trans on Pattern Analysis and Machine In- telligence2004，26，1： | 1 |
| 16 | Phosphorylation of extra - nu- clear ERK/MAPK is required for long - term memory eonsolidation in the crab Chasmagnathus 显示文摘 | Mariana F Beatfiz D Alejandro D | 2005 | Behav Brain Res2005，158，2： | 1 |
| 17 | Phosphorylation of extra - nu-clear ERK /MAPK is required for long - term memory consolidation inthe crab Chasmagnathus显示文摘 | Mariana F Beatriz D Alejandro D | 2005 | Behavioural Brain Res2005，158，2： | 1 |
| 18 | Twodimensional PCA: A new approach to appearancebased face representation and recognition 显示文摘 | YANG J ZHANG D ALEJANDRO F F | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 19 | Two-Dimen sional PCA: A New Approach to Appearance Based Face Representation and Recognition显示文摘 | Yang J Zhang D Frangi Alejandro F | 2004 | Journal of IEEE Transaction on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 20 | Antiatherogenic and anti-angiogenic activities of polyphenols from propolis显示文摘 | Julio B D Vanessada S F Alejandro P | 2011 | Journal of Nutritional Biochemistry2011，，7： | 1 |
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