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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Formation of an ant cemetery: Swarm intelligence of statistical accident显示文摘 | Martin M Chopard B Albuquerque P | 2002 | Future Generation Computer Systems2002，18，： | 2 |
| 5 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 6 | Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 显示文摘 | Tso L O Costello M F Albuquerque L E | 2009 | Cochrane Database Syst Rev2009，，00： | 1 |
| 7 | Muttimodal MRI-Based Study in Patients with SPG4 Mutationse 显示文摘 | Rezende TJ de Albuquerque M Lamas GM | 2015 | PLoS On2015，10，01： | 1 |
| 8 | Transesterification of ethyl butyrate with methanol using MgO/CaOcatalyst 显示文摘 | ALBUQUERQUE M C G AZEVEDO D C S CAVALCANTE C L | 2009 | Journal of Molecular Catalysis A : Chemical2009，300，12： | 1 |
| 9 | A randomized controlled trial comparing vaginal misoprostol versus Foley catheter plus oxytocin for labor induction 显示文摘 | MORAES FILHO O B ALBUQUERQUE R M CECATYI J G | 2010 | Acta Obstetricia et Gyriecologica Scandinavica2010，89，8： | 1 |
| 10 | Trends in the analytical methods for the determinationof trans fatty acids content in foods显示文摘 | ALBUQUERQUE T G COSTA H S CASTILHO M C | 2011 | Trends in Food Scienceand Technology2011，22，11： | 1 |
| 11 | Image thresholding using Tsallis entropy 显示文摘 | Poftes de Albuquerque M Esquef I A Gesualdi Mello A R | 2004 | Pattern Recognition Letters2004，25，9： | 1 |
| 12 | Biofilm development and ammonia removal in the nitrification of a saline wastewater显示文摘 | Rosa M F Furtado A A L Albuquerque R T | 1998 | Bioresource Technology1998，65，12： | 1 |
| 13 | Formation of an ant cemetery: Swarm intelligence or statistical accident显示文摘 | Martin M Chopard B Albuquerque P | 2002 | Future Generation Computer Systems2002，18，7： | 1 |
| 14 | Strategies for the development of a side stream process for poly- hydroxyalkanoate (PHA) production from sugar cane mo- lasses 显示文摘 | Albuquerque M G E Eiroa M Torres C | 2007 | Journal of Biotechnology2007，130，： | 1 |
| 15 | Antimicrobial and insecticidal activities of cashew tree gum exudates显示文摘 | MARQUES M K ALBUQUERQUE L M XAYIER-FILHO J | 1992 | Annals of Applied Biology1992，121，2： | 1 |
| 16 | Structural analysis and optimization in the framework ofreduced-basis method 显示文摘 | Afonso S M B Lyra P R M Albuquerque T M M | 2010 | Structural andMultidisciplinary Optimization2010，40，16： | 1 |
| 17 | Image thresholding using Tsallis entropy显示文摘 | Pones de Albuquerque M Esquef I A Gesualdi Mello A R | 2004 | Pattern Rec- ognition Letters2004，25，9： | 1 |
| 18 | Biological sulphate reduction and redox mediator effects on azo dye decolourisation in anaerobic-aerobic sequen- cing batch reactors显示文摘 | ALBUQUERQUE M G E LOPES A T SERRALHEIRO J M | 2005 | Enzyme and Microbial Technology2005，36，79： | 1 |
| 19 | Formation of an ant cemetery: swarm intelligence or statistical accident? 显示文摘 | MARTIN M CHOPARD B ALBUQUERQUE P | 2002 | Future Generation Computer Systems2002，，18： | 1 |
| 20 | Image thresholding using Tsallis entropy 显示文摘 | De Albuquerque M P Esquef I A Gesualdi Mello A R | 2004 | Pattern Recognition Letters2004，25，9： | 1 |
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