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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Insulin resistance in H pylori infection and its association with oxidative stress显示文摘AIM: To determine the insulin resistance (IR) and oxidative status in H pylori infection and to find out if there is any relationship between these parameters and insulin resistance. METHODS: Fifty-five H pylori positive and 48 H pylori negative patients were enrolled. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Serum total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined in all subjects. RESULTS: The total antioxidant capacity was significantly lower in H pylori positive group than in H pylori negative group (1.36 ± 0.33 and 1.70 ± 0.50, respectively; P < 0.001), while the total oxidant status and oxidative stress index were significantly higher in H pylori positive group than in H pylori negative group (6.79 ± 3.40 and 5.08 ± 0.95, and 5.42 ± 3.40 and 3.10 ± 0.92, respectively; P < 0.001). Insulin resistance was significantly higher in H pylori positive group than in H pylori negative group (6.92 ± 3.86 and 3.61 ± 1.67, res- pectively; P < 0.001). Insulin resistance was found to be significantly correlated with total antioxidant capacity (r = -0.251, P < 0.05), total oxidant status (r = 0.365, P < 0.05), and oxidative stress index (r = 0.267, P < 0.05). CONCLUSION: Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Further studies are needed to clarify the mechanisms underlying this association and elucidate the effectof adding antioxidant vitamins to H pylori eradication therapy on insulin resistance during H pylori infection. | Mehmet Aslan Mehmet Horoz Yasar Nazligul Cengiz Bolukbas F Fusun Bolukbas Sahbettin Selek Hakim Celik Ozcan Erel | 2006 | World Journal of Gastroenterology2006，12，42： | 15 |
| 3 | He/icobacter py/ori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin显示文摘AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched nonuremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched.The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05).CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population. | Selim Aydemir Sedat Boyacioglu Gurden Gur Muge Demirbilek Fusun Kamber Can Murat Korkmaz Ugur Yilmaz | 2005 | World Journal of Gastroenterology2005，11，6： | 5 |
| 4 | Dexmedetomidine Added to Levobupivacaine Prolongs Axillary Brachial Plexus Block显示文摘 | Aliye Esmaoglu Fusun Yegenoglu Aynur Akin Cemil Yildirim Turk | 2010 | Anesthesia & Analgesia2010，，6： | 3 |
| 5 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 6 | Effect of abdominal trauma on hemorrhagic shock-induced acute lung injury in rats显示文摘瞄准:在老鼠在出血性的导致吃惊的尖锐的肺损害上评估腹的损伤的效果。方法:五个组被分配(n = 8 ) 在学习。我作为控制组,被带的组作为出血性的吃惊组,组织 II 是的组 III 出血性的吃惊 + 剖腹术,是的组 IV 是的出血性的吃惊 + 脾切除术和组 V 脾切除术 + 网膜切除术 + 出血性的吃惊组。出血性的吃惊被拉血并且在 10 min 以内把吝啬的动脉压(地图) 归结为 40 毫米汞柱导致。在 1 h 的一个低血压患者时期以后,动物被复活。Bronchoalveolar 洗室年龄(BAL ) 被执行在复活 malondialdehyde (MDA ) 以后与 BAL 液体的 40 mL 从牙槽的空间恢复房间, L-gamma-glutamyl-L-cysteinyl-glycine (GSH ) 层次在浆液,红血球和肺织物被测量。结果:浆液,红血球,肺织物 MDA 和 GSH 层次显著地在出血性的吃惊组 II-V 被增加(P <
0.05 ) 。在 BAL 液体的淋巴细胞, neutrophil 和牙槽的巨噬细胞计数显示了在控制和吃惊组之间的有效差量(P <
0.05 ) 。结论:损伤的度增加出血性的导致吃惊的尖锐的肺损害。 | Bulent Kilicoglu Erol Eroglu Sibel Serin Kilicoglu Kemal Kismet Fusun Eroglu | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 7 | The analgesic effect of EMLA cream on sore throat following tracheal intubation显示文摘 | Fusun E Aysegul U Erol E | 2002 | Pain Clinic2002，14，1： | 1 |
| 8 | The comparison of pul- monary functions in open versus laparoscopic cholecystee- tomy显示文摘 | Osman Y Fusun A Serpil A | 2009 | J Pak Med Assoc2009，59，4： | 1 |
| 9 | Progressive autosomal dominant optic atrophy and sensorineural hearing loss in a Turkish family显示文摘 | Ozden Serap Duzcan Fusun | 2002 | Ophthalmic - Genes2002，23，1： | 1 |
| 10 | Addition of inhaled corticosteroid on combined bronchodilator therapy in patients with COPD显示文摘 | Ilknur B Fusun Y Sevgiye K | 2005 | Pulmonary Phannacol Ther2005，18，6： | 1 |
| 11 | Percutaneously inserted central catheters in the newborns: A center’s experience in Turkey显示文摘 | Ali Bulbul Fusun Okan Asiye Nuhoglu | 2010 | Journal of Maternal-Fetal and Neonatal Medicine2010，，6： | 1 |
| 12 | Partial preoperative reduction of inguinal hernia through compression with an ultrasound transducter显示文摘 | Kutsi Koseoglu Yelda Ozsunar Fusun Taskin | 2003 | Journal of Clinical Uhrasound2003，31，7： | 1 |
| 13 | Huge cavemoma with massive intracerebral hemorrhage in a child 显示文摘 | Emel AVCl AdiloZTuRK Fusun BABA | 2007 | Turkish Neumsurgery2007，17，1： | 1 |
| 14 | A serological case-control study of primary hepatocellular carcinoma in Guangxi显示文摘 | Chichun Mo Si Luo | 1985 | China Cancer Res1985，45，： | 1 |
| 15 | Promotion of Prescription Drugs and Its Impact on Physicians' Choice Behavior显示文摘 | Gonul Fusun F Franklin Carter | 2001 | Journal of Marketing2001，65，3： | 1 |
| 16 | Predictors of hospital outcome and intubation in COPD patients admitted to the respiratory ICU for acute hypercapnic respiratory failure显示文摘 | Irfan Ucgun Muzaffer Metintas Hale Moral Fusun Alatas Huseyin Yildirim Sinan Erginel | 2005 | Respiratory Medicine2005，，1： | 1 |
| 17 | The role of CD14 gene promoter polymorphism in tuberculosis susceptibility显示文摘 | Ergin Ayaslioglu Fusun Kalpaklioglu Ayse Baccioglu Kavut Arzu Erturk Nermin Capan Esra Birben | 2013 | Journal of Microbiology, Immunology and Infection2013，，： | 1 |
| 18 | The Effectiveness of Lamivudine Treatment in Cirrhotic Patients with HBV Precore Mutations: A Prospective, Open-Label Study显示文摘 | Cengiz Bolukbas MD Fusun Filiz Bolukbas MD Tulin Kendir MD Nihat Akbayir MD Ali Tuzun Ince MD Evren Abut MD Mehmet Horoz MD Ali Remzi Dalay MD Mehmet Haci Sokmen MD Oya Ovunc MD | 2006 | Digestive Diseases and Sciences2006，，7： | 1 |
| 19 | The Role of RELN in Lissencephaly and Neuropsychiatric Disease显示文摘 | Bernard S Fusun Duzcan Seonhee Kim | | 0，，02： | 1 |
| 20 | Uptake of nitrogen from indigenous soil pool by cotton plant inoculated with arbuscular mycorrhizal fungi显示文摘 | FENG Gu ZHANG Fusun LI Xiaolin | 2002 | Commun Soil Sci Plant Anal2002，33，1920： | 1 |
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