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| 1 | Clinical usefulness of endoscopic ultrasonography for the evaluation of ulcerative colitis-associated tumors显示文摘AIM:To evaluate the clinical usefulness of endoscopic ultrasonography(EUS) for the diagnosis of the invasion depth of ulcerative colitis-associated tumors.METHODS:The study group comprised 13 patients with 16 ulcerative colitis(UC)-associated tumors for which the depth of invasion was preoperatively estimated by EUS.The lesions were then resected endoscopically or by surgical colectomy and were examined histopathologically.The mean age of the subjects was 48.2 ± 17.1 years,and the mean duration of UC was 15.8 ± 8.3 years.Two lesions were treated by endoscopic resection and the other 14 lesions by surgical colectomy.The depth of invasion of UCassociated tumors was estimated by EUS using an ultrasonic probe and was evaluated on the basis of the deepest layer with narrowing or rupture of the colonic wall.RESULTS:The diagnosis of UC-associated tumors by EUS was carcinoma for 13 lesions and dysplasia for 3 lesions.The invasion depth of the carcinomas was intramucosal for 8 lesions,submucosal for 2,the muscularis propria for 2,and subserosal for 1.Eleven(69%) of the 16 lesions arose in the rectum.The macroscopic appearance was the laterally spreading tumor-non-granular type for 4 lesions,sessile type for 4,laterally spreading tumor-granular type for 3,semipedunculated type(Isp) for 2,type 1 for 2,and type 3 for 1.The depth of invasion was correctly estimated by EUS for 15 lesions(94%) but was misdiagnosed as intramucosal for 1 carcinoma with high-grade submucosal invasion.The 2 lesions treated by endoscopic resection were intramucosal carcinoma and dysplasia,and both were diagnosed as intramucosal lesions by EUS.CONCLUSION:EUS provides a good estimation of the invasion depth of UC-associated tumors and may thus facilitate the selection of treatment. | Kiyonori Kobayashi Kana Kawagishi Shouhei Ooka Kaoru Yokoyama Miwa Sada Wasaburo Koizumi | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 2 | 炎症性肠病的研究现状显示文摘炎症性肠病(IBD)首先在北欧和北美洲人群中发现,以后在世界各地均有报道[1]。IBD是一类病因尚未明确的慢性非特异度肠道炎症,包括溃疡性结肠炎(UC)和克罗恩病(CD),临床表现为反复腹痛、腹泻、黏液血便。近年来我国的IBD发病率不断增高[2],可能是环境、遗传、感染、免疫、内脏的敏感性及精神因素等多因素相互作用所致[3]。随着治疗方案的不断改进及生物制剂的应用。 | 张兰兰 牛润章 司依馨 | 2012 | 中国实用内科杂志2012，32，S2： | 3 |
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