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| 1 | 不同耕作措施对冬小麦-夏玉米复种连作系统土壤有机碳和水分利用效率的影响显示文摘在连续8年田间定位试验的基础上,分析了关中平原冬小麦一夏玉米复种连作系统2008--2009年连续两个生长季期间不同耕作措施(结合秸秆还田和不还田)对土壤有机碳和水分利用率的影响.结果表明:相对于传统耕作,保护性耕作有利于土壤有机碳、水分利用效率和作物产量的提高,其中在“深松+秸秆还田”耕作模式下的增幅最高,土壤有机碳含量在0~30cm土层增幅达到19.5%,水分利用效率和作物产量提高了16.9%和20.5%,而免耕模式则有效提高了0~10cm土层有机碳含量.在该地区土壤和气候条件下,深松结合秸秆粉碎还田是最理想的耕作模式,最有利于土壤有机碳累积,并提高水分利用效率和作物产量. | 姬强 孙汉印 Taraqqi AK 王旭东 | 2014 | 应用生态学报2014，25，4： | 32 |
| 2 | Sirtuin 6抑制平滑肌细胞衰老,减少动脉粥样硬化显示文摘血管平滑肌细胞(vascular smooth muscle cell, VSMC)衰老促进动脉粥样硬化及斑块不稳定性,部分是通过脂质介导的DNA氧化损伤和端粒功能障碍起作用。Sirtuin 6(SIRT6)是一种核去乙酰化酶,参与DNA损伤应答信号转导、炎症反应和代谢。然而,其在调节VSMC衰老和动脉粥样硬化中的作用尚不清楚。 | 陈嘉睿(译) 练桂丽(审校) Grootaert M Finigan A Figg N Uryga AK Bennett M | 2021 | 中华高血压杂志2021，29，3： | 21 |
| 3 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 4 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 5 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 6 | Assessment of germ cell apoptosis in cryptorchid rats显示文摘Aim:To investigate the relationship between germ cell edgeneration and apoptosis in cryptorchid rats.Methods:Thirteen21-day-oldWistar rats were made unilaterally cryptorchid by closing the left inguinal canal.At day30(Group1,n =6)and day60(Group2,n=7)after operation,the testes were removed for histopathological examination.30(Group1,n=6)and day60(Group2,n=7)after operation,the testes were removed for histopathological examination.The controls(n=8)were sham operated and were sacrificed at day60.Germ cell apoptosis was assessed by means of theTUNEL method.Results:Spermatogenesis was arrested and the testicular and seminiferous tubular diameters were significantly reduced In the Unilateral undescended testes(UUTs)compared with the contralateral descended testes(CDTs)and the control rats.However,atrophic changes,pathological calcification,necrosis of seminiferous tubule,and absence or sloughing of germ cells were not found in all the animals,The spermatocytes were the main type of germ cells undergoing apoptosis in all the groups.In the UUTs,there was a significant and time-dependent increase in the mean apoptotic index.By60days after surgery,increased apoptosis in gern cells was also observed in the CDTs.Conclusion:Apoptosis is the predominant mechanism of germ cell death rather than atrophy and necrosis in cryptorchidism. | IzzetKoak MehmetDündar Mine Hekimgil Pinar Okyay | 2002 | Asian Journal of Andrology2002，4，3： | 11 |
| 7 | Dysregulation of gastric H,K-ATPase by cigarette smoke extract显示文摘AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke extract.METHODS: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase activity.RESULTS: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer. | Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam | 2009 | World Journal of Gastroenterology2009，15，32： | 7 |
| 8 | Molecular basis for identification of species/isolates of gastrointestinal nematode parasites显示文摘Gastrointestinal(GI) parasitism is the most serious constraint throughout the world in small ruminants which causes significant production loss in animals.GI parasites are major contributor to reduce productivity in terms of meat,milk and wool in animals.Control of GI parasite is done primarily by anthelmintic treatment where choice and schedule of treatment is done after identification and quantitation of individual parasite.Identification of GI parasites is done through microscopic method by identifying specific morphological characteristics of egg and larva(L3).Since most of parasite eggs are having similar morphological characteristics, identification up to species level through microscopy is not possible in most of cases.To address this issue,molecular techniques are the viable alternative for identification of species as well as molecular level differences within a species(isolates) of parasites.Different DNA based molecular techniques viz.PCR,AFLP,RAPD,RFLP,PCR-SSCP,real time PCR,DNA microarray etc.have been used for identification and to assess the genetic diversity among parasite population.For identification of species,the characteristic sequence of genomic DNA of different species should differ to allow the delineation of species,but at the same time,no/minor variation within the species should exist.In contrast,for purpose of identifying population variants(strains/isolates), a considerable degree of variation in the sequence should exist within a species.Various target regions,including nuclear ribosomal DNA(rDNA),mitochondrial DNA(mtDNA) or repetitive DNA elements(microsatellite loci),which show considerable variation in the number of repeats within individuals have been employed to achieve the identification of parasites species or strain. | Ahmed M Singh MN Bera AK Bandyopadhyay S Bhattacharya D | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 6 |
| 9 | 不同pH值培养液对肝细胞一氧化氮合成的影响显示文摘目的 探讨不同 pH值条件对肝细胞培养时一氧化氮 (NO)产生的影响及对肝细胞的损伤程度。方法 本研究首先将成年健康大鼠经静脉注射灭活有毒棒状杆菌 ,感染 4天后处死动物取肝脏作肝细胞分离并培养 ,2 4h后在培养液中加入L 精氨酸 ,同时将培养液调节成pH7.0、pH7.4及 pH7.8三组 ,又在每一 pH处理组中分出对照组 (CP组 )、大肠杆菌内毒素刺激组 (CP +LPS组 )及单甲基精氨酸抑制组 (CP +LPS +NMA组 ) ,继续培养 2 4h。结果 CP组产生约 10 0 μmol/L的NO ,pH值的改变对其无明显影响。在CP +LPS处理的肝细胞 ,pH7.4及 pH7.8组的值分别为 (2 39.3± 18) μmol/L及(2 2 8.4± 14.7) μmol/L ,显著高于pH7.0组 ((16 3.2± 5 .7) μmol/L ,P <0 .0 1)。加用NMA后 ,一氧化氮的产生明显减少 ,但三组间差异无显著性。加用LPS后肝细胞的损伤加重 ,pH7.0组LDH及ALT值显著高于 pH7.4及pH7.8组。当应用NMA抑制NO生成时 ,培养液中乳酸脱氢酶 (LDH)和丙氨酸转氨酶 (ALT)值显著升高 ,并以酸性组为明显。在CP组肝细胞 ,iNOS的产生量在三种不同 pH处理间无明显差别 ,加用LPS刺激后 ,iNOS的合成明显增加 ,而且酸性或碱性情况下iNOS的合成较 pH7.4时更高。结论 对处于炎症状态的肝细胞 ,酸性环境会抑制一氧化氮合成 。 | 舒志军 韩伏莅 Jung M Beger HG Nuessler AK | 2000 | 中华消化杂志2000，20，1： | 6 |
| 10 | 血管瘤的临床表现及处理显示文摘The presentation and management of heman- giomas. Beck DO, Gosain AK. Plast Reconstr Surg, 2009, 123(6):181e-91e. | Beck DO Gosain AK | 2009 | 中国口腔颌面外科杂志2009，7，4： | 6 |
| 11 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 12 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 13 | Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients显示文摘AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis.METHODS: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo.RESULTS: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score.CONCLUSION: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. | KA Attia KC Ackoundou-N'guessan AT N’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 14 | 正常高值血压者心脏迷走神经调节、氧化应激和心血管疾病危险因素的横断面研究显示文摘高血压是心血管疾病的可控危险因素之一,与氧化应激增强和心脏迷走神经调节减弱相关。同样,正常高值血压也与心血管事件的风险增加相关。该研究探索正常高值血压和心脏迷走神经调节、氧化应激及心血管危险因素之间的相关性。 | Thiyagarajan R Pal P Pal GK Subramanian SK Bobby Z Das AK Trakroo M 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，9： | 5 |
| 15 | Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property显示文摘Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata(R.mucronata) leaf extract against the larvae of Aedes aegypti(Ae.aegypti) and Culex quinquefasciatus(Cx.quinquefasciatus).Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the Ae.aegypti and Cx.quinquefasciatus larval species.Further, characterisation such as UV,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano particles.Results:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for Ae.aegypti and Cx.quinquefasciatus larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for Ae.aegypti and Cx. quinquefasciatus species respectively.The synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 nm.The XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in(3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12) different ranges.Conclusions:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases. | M Gnanadesigan M Anand S Ravikumar M Maruthupandy V Vijayakumar S Selvam M Dhineshkumar AK Kumaraguru | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 4 |
| 16 | AZ31镁合金激光焊件的力学性能和应力腐蚀行为(英文)显示文摘采用Nd-YAG激光对AZ31 HP镁合金进行激光自熔焊接。显微组织分析表明,使用或不使用填料(焊料)AZ61镁合金得到的激光焊接接头的平均晶粒尺寸大约为12μm,显微硬度和拉伸强度与母材相近。然而,慢应变速率拉伸表明,在ASTM D1384溶液中两种焊接接头的抗应力腐蚀性能比母材略差。可观察到应力腐蚀裂纹在焊缝金属萌生并向热影响区(HAZ)扩展。然而,在以AZ61镁合金为填料(焊料)获得的焊接接头中,观察到裂纹起源及扩展出现在热影响区(HAZ)。在慢应变速率拉伸试验中,由于试样表面暴露在腐蚀环境中,在氢氧化镁/氧化镁层形成局部损伤,从而导致应力腐蚀裂纹的生成。 | P.B.SRINIVASAN S.RIEKEHR C.BLAWERT W.DIETZEL M.KO AK | 2011 | Transactions of Nonferrous Metals Society of China2011，21，1： | 4 |
| 17 | Effects of manganese doping on magnetocaloric effect in Ge-rich Gd_5Ge_(2.05)Si_(1.95) alloy显示文摘The structure, magnetic and magnetocaloric properties of the Ge-rich Gd5Ge2.05-xSi1.95-xMn2x (x=0.01 and 0.03) alloys were investigated by scanning electron microscopy, X-ray powder diffraction, differential scanning calorimeter (DSC) and magnetization measurements. The results of energy dispersive X-ray analysis (EDX) and X-ray diffraction analyses showed that the composition and crystal structure of the alloys were desired. DSC measurements were performed to determine the transformation temperatures for each alloy. Both alloys exhibited the first order phase transition around room temperature. The alloys showed an anti-ferromagnetic transition around 60 K. The isothermal magnetic entropy changes of the alloys were determined from the isothermal magnetization measurements by using the Maxwell relation. The maximum values of isothermal magnetic entropy change of the Gd5Ge2.05-xSi1.95-xMn2x alloy with x=0.01 was found to be -12.1 and -19.8 J/(kg·K) using Maxwell equation around 268 K in applied fields of 2 and 5 T, respectively. | E.Yüzüak I.Dincer Y.Elerman | 2012 | Journal of Rare Earths2012，30，3： | 4 |
| 18 | Is the pain in chronic pancreatitis of neuropathic origin? Support from EEG studies during experimental pain显示文摘AIM: To prove the hypothesis that patients with chronic pancreatitis would show increased theta activity during painful visceral stimulation. METHODS: Eight patients and 12 healthy controls underwent an experiment where the esophagus was electrically stimulated at the pain threshold using a nasal endoscope. The electroencephalogram (EEG) was recorded from 64 surface electrodes and 'topographic matching pursuit' was used to extract the EEG information in the early brain activation after stimulation. RESULTS: A major difference between controls and patients were seen in delta and theta bands, whereas there were only minor differences in other frequency bands. In the theta band, the patients showed higher activity than controls persisting throughout the 450 ms of analysis with synchronous brain activation betweenthe channels. The main theta components oscillated with 4.4 Hz in the patients and 5.5 Hz in the controls. The energy in the delta (0.5-3.5 Hz) band was higher in the controls, whereas the patients only showed scattered activity in this band. CONCLUSION: The differences in the theta band indicate that neuropathic pain mechanisms are involved in chronic pancreatitis. This has important implications for the understanding and treatment of pain in these patients, which should be directed against drugs with effects on neuropathic pain disorders. | AsbjФrn M Drewes Maciej Gratkowski Saber AK Sami Georg Dimcevski Peter Funch-Jensen Lars Arendt-Nielsen | 2008 | World Journal of Gastroenterology2008，14，25： | 4 |
| 19 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action显示文摘AIM: To evaluate the protective activity of allylpyrocatechol (APC), the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties. METHODS: Male Sprague-Dawley rats were divided into five groups. Normal control rats (group Ⅰ) were given the vehicle oral dose of gum acacia in distilled water (1 mL per rat); ulcerated control and treated rats (groups Ⅱ-Ⅴ) were given a single dose of indomethacin (30 mg/kg body wt.); group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle (1 mL per rat) or APC (2 mg/kg body wt.) or misoprostol (1.43 μg/kg body wt.) once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS: Treatment with APC (2 mg/kg body wt per day) and misoprostol (1.43 μg/kg body wt per day) for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively (P < 0.05). Both APC and misoprostol accelerated ulcer healing observed in natural recovery (P < 0.05), their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhancethe mucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and misoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively (P < 0.05). Likewise, both APC and misoprostol increased the SOD, catalase, and mucin levels significantly (P < 0.05), the effect of APC being better. CONCLUSION: APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties. | S Bhattacharya D Banerjee AK Bauri S Chattopadhyay SK Bandyopadhyay | 2007 | World Journal of Gastroenterology2007，13，27： | 4 |
| 20 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
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