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| 1 | A Study on the Protective Effect of Cynodon dactylon Leaves Extract in Diabetic Rats显示文摘Objective To investigate the antidiabetic, antioxidant and hypolipidemic efficacy of Cynodon dactylon in diabetic rats. Methods The experimental rats were randomly divided into three groups: Group I: control; Group II: Alloxan diabetic, untreated; and Group III: Alloxan diabetic treated with ethanolic extract of C. dactylon leaves (450 mg/kg bw). Experimental diabetes was induced by alloxan in a single dose of 150 mg/kg bw. Results A Significant diminution of fasting blood sugar level was observed and also significant increase in HDL and decrease (P<0.05) in cholesterol, triglyceride, LDL and VLDL were observed after 15 days of treatment. The investigation also revealed, the activities of AST, ALT, ALP, AP, LDH, and CPK (P<0.05) were decreased in the extract‐supplemented group. The significant decrease in protein content and SOD, CAT, GPx, and GSH (P<0.05) activity and increase in LPO in plasma were found to be ameliorated after treatment. Conclusion Our result supports the fact that administration of extract of C. dactylon leave is able to reduce hyperglycemia and hyperlipidemia risk and also reduced the oxidative stress in diabetic rats. | Karthik D Ravikumar S | 2011 | Biomedical and Environmental Sciences2011，24，2： | 10 |
| 2 | Influence of heat treatment on the machinability and corrosion behavior of AZ91 Mg alloy显示文摘In the present study,AZ91 Mg alloy was heat treated at 410℃ for 6,12 and 24 h to investigate the influence of heat treatment on machinability and corrosion behavior.The effect of soaking time on the amount and distribution of Mg 17 Al 12(β-phase)was analyzed under the optical microscope.Microhardness measurements demonstrated the increased hardness with increased heat treatment soaking time,which can be attributed to the solid solution strengthening.The influence of super saturatedα-grains on reducing the cutting force(F z)with respect to increased cutting speed was observed as prominent.The corrosion behavior of the heat treated specimens was studied by conducting electrochemical tests.Surprisingly,corrosion rate of heat treated samples was observed as increased compared with the base material.From the results,it is evident that the machinability of AZ91 Mg alloy can be improved by producing super saturatedα-grains through heat treatment but at the cost of losing corrosion resistance. | Swetha Chowdary V Ravikumar Dumpala Anand Kumar S Kondaiah VV Ratna Sunil B | 2018 | Journal of Magnesium and Alloys2018，6，1： | 7 |
| 3 | Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property显示文摘Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata(R.mucronata) leaf extract against the larvae of Aedes aegypti(Ae.aegypti) and Culex quinquefasciatus(Cx.quinquefasciatus).Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the Ae.aegypti and Cx.quinquefasciatus larval species.Further, characterisation such as UV,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano particles.Results:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for Ae.aegypti and Cx.quinquefasciatus larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for Ae.aegypti and Cx. quinquefasciatus species respectively.The synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 nm.The XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in(3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12) different ranges.Conclusions:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases. | M Gnanadesigan M Anand S Ravikumar M Maruthupandy V Vijayakumar S Selvam M Dhineshkumar AK Kumaraguru | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 4 |
| 4 | Anticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines显示文摘Objective:To investigate the anticancer property of marine sediment actinomvceles against two different breast cancer cell lines.Methods:In vitro anticancer activity was carried out against breast(MCF-7 and MDA-MB-231)cancer cell lines.Partial sequences of the 16s rRNA gene,phylogenetic tree construction,multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes isolates.Results:Of the selected five actinomycete isolates,ACT01 and ACT02 showed the IC_(50)value with(10.13±0.92)and(22.34±5.82)μg/mL concentrations,respectively for MCF-7 cell line at 48 h,but ACT01 showed the minimum(18.54±2.49μg/mL)level of IC_(50)value with MDA-MB-231 cell line.Further,the 16s rRNA partial sequences of ACT01,ACT02,ACT03,ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246,GQ478247,GQ478248,GQ478249 and GQ478250.respectively.The phylogenetic tree analysis showed that,the isolates of ACT02 and ACT03 were represented in groupⅠandⅢ,respectively,but ACT01 and ACT02 were represented in groupⅡ.The multiple sequence alignment of the actinomycete isolates showed that,the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs,65 to 119th base pairs and 55,48 and 31st base pairs.Secondary structure prediction of the 16s rRNA showed that,the maximum free energy was consumed with ACT03 isolate(-45.4 kkal/mol)and the minimum free energy was consumed with ACT04 isolate(-57.6 kkal/mol).Conclusions:The actinomycete isolates of ACT01 and ACT02(GQ478246 and GQ478247)which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines. | Ravikumar S Fredimoses M Gnanadesigan M | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 5 | In vitro antibacterial potential of metal oxide nanoparticles against antibiotic resistant bacterial pathogens显示文摘 | R Gokulakrishnan S Ravikumar J Anandha Raj | 2012 | Asian Pacific Journal of Tropical Disease2012，，5： | 2 |
| 6 | Rapamycin andmTOR-independent autophagy inducers ameliorate toxicityof polyglutamine-expanded huntingtin and related protei-nopathies显示文摘 | Sarkar S Ravikumar B Floto RA | 2009 | Cell Death Differ2009，16，1： | 1 |
| 7 | Regulation of mammalian autophagy in physiology and pathophysiology显示文摘 | Ravikumar B Sarkar S Davies JE | 2010 | Physiol Rev2010，90，4： | 1 |
| 8 | Ten-year follow-up of breast carcinoma in situ in connecticut显示文摘 | Ward B A Mckhann C F Ravikumar T S | 1992 | Arch Surg1992，127，： | 1 |
| 9 | Application of response surface methodology to optimize the process variables for reactive red and acid brown dye removal using a novel adsorbent显示文摘 | RAVIKUMAR K RAMALINGAM S KRISHNAN S | 2006 | Dyes and Pigmcnts2006，70，1： | 1 |
| 10 | Regulation of mammalian autophagy in physiology and pathophysiology显示文摘 | Ravikumar B Sarkar S Davies JE | 2010 | Physiol Rev2010，90，： | 1 |
| 11 | Regulation of mamma- lian autophagy in physiology and pathophysiology 显示文摘 | Ravikumar B Sarkar S Davies JE | 2010 | Physiol Rev2010，90，4： | 1 |
| 12 | Analysis of failures in boiler tubes due to fireside corrosion in a waste heat recovery boiler显示文摘 | SRIKANTH S RAVIKUMAR B GOPALAKRISHNA K | 2003 | Eng Fail Anal2003，10，： | 1 |
| 13 | Raman spectroscopic study of phase transitions in natural gypsum显示文摘 | Sarma L P Prasad P S R Ravikumar N | 1998 | J Raman Spectrosc1998，，29： | 1 |
| 14 | Antibacterial potential of biosynthe-sized silvernanoparticles using Avicennia marina mangroveplant显示文摘 | Gnanadesigan M Anand M Ravikumar S | 2012 | Applied nanoscience2012，，2： | 1 |
| 15 | 25-year experience with 456 combined mitral and aortic valve replacement for rheumatic heart disease显示文摘 | John S Ravikumar E John CN | 2000 | Ann Thorac Surg2000，69，4： | 1 |
| 16 | Virtual screening of cathepsin k inhibitors using docking and pharmacophore models显示文摘 | Ravikumar M Pavan S Bairy S | 2008 | Chem Biol Drug Des2008，72，1： | 1 |
| 17 | Raman Spectroscopic Study of Phase Transitions in Natural Gypsum 显示文摘 | Sarma L P Prasad P S R Ravikumar N | 1998 | Raman Spectrose1998，29，： | 1 |
| 18 | J Appl Electrochem显示文摘 | Shukla A K Ravikumar M K Arico A S | 1995 | 389:5281995，389，： | 1 |
| 19 | Rapamycin and mTOR- independent autophagy inducers ameliorate toxicity of polyglu- tamine-expanded huntingtin and related proteinopathies 显示文摘 | Sarkar S Ravikumar B Floto RA | 2009 | Cell Death Differ2009，16，1： | 1 |
| 20 | Synthesis and biologicalevaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2Inhibitors显示文摘 | Singh S K Saibaba V Ravikumar V | 2004 | Bioorg Med Chem2004，12，8： | 1 |
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