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| 1 | 为 cholangiocarcinoma 的化疗: 更改显示文摘 Cholangiocarcinomas(bile duct cancers) are a heterogeneous group of malignancies arising from the epithelial cells of the intrahepatic,perihilar and extrahepatic bile ducts.Patients diagnosed with cholangiocarcinoma must be evaluated by a multidisciplinary team and be treated with individualized management.First of all,it is very important to define the potential resectability of the tumor because surgery is the main therapeutic option for these patients.Overall,cholangiocarcinomas have a very poor prognosis.The 5 year survival rate is 5%-10%.In cases with a potentially curative surgery,5 year survival rates of 25%-30% are reported.Therefore,it is necessary to increase the cure rate from surgery,exploring the survival benefit of any adjuvant strategy.It is difficult to clarify the role of adjuvant treatment in localized and locally advanced cholangiocarcinomas.There are limited data and the role of adjuvant chemotherapy/chemoradiation in patients with resected biliary tract cancer is poorly defined.The most relevant studies in the adjuvant setting are one from Japan,the well known ESPAC-3 and BILCAP from the United Kingdom and a meta-analysis.We show the results of these trials.According to medical oncology guidelines,postoperative adjuvant therapy is widely recommended for all patients with intrahepatic or extrahepatic cholangiocarcinoma who have microscopically positive resection margins,as well as for those with a complete resection but node-positive disease.Clinical trials are ongoing.The locally advanced cholangiocarcinoma setting includes a heterogeneous mix of patients:(1) patients who have had surgery but with macroscopic residual disease;(2) patients with locally recurrent disease after potentially curative treatment;and(3) patients with locally unresectable disease at presentation.In these patients,surgery is not an option and chemoradiation therapy can prolong overall survival and provide control of symptoms due to local tumor effects.Nowadays,no neoadjuvant therapy can be considered a standard approach for the treatment of patients with cholangiocarcinoma.There are promising results and randomized trials are needed in patients with a metastatic cholangiocarcinoma.In systemic therapy,no single drug or combination has consistently increased median survival beyond the expected 8-12 mo.It is always recommended that patients enrol in clinical trials.Clinical trials have shown that the more standard chemotherapy for a first line regimen of gemcitabine plus cisplatin(or oxaliplatin as a potentially better tolerated agent) is superior to gemcitabine alone.Leucovorinmodulated 5-fluorouracil,capecitabine monotherapy or single agent gemcitabine are reasonable options for patients with a borderline performance status.After progression in patients with an adequate performance status,active regimens that could be considered include gemcitabine plus capecitabine,or erlotinib plus bevacizumab,for second line treatment. | Natalia Ramírez-Merino Santiago Ponce Aix Hernán Cortés-Funes | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 20 |
| 2 | The impacts of conservation agriculture on crop yield in China depend on specific practices, crops and cropping regions显示文摘For smooth and wide application of conservation agriculture(CA), remaining uncertainties about its impacts on crop yield need to be reduced. Based on previous field experiments in China, a meta-analysis was performed to quantify the actual impacts of CA practices(NT: no/reduced-tillage only, CTSR: conventional tillage with straw retention, NTSR: NT with straw retention) on crop yields as compared to conventional tillage without straw retention(CT).Although CA practices increased crop yield by 4.6% on average, there were large variations in their impacts. For each CA practice, CTSR and NTSR significantly increased crop yield by 4.9%and 6.3%, respectively, compared to CT. However, no significant effect was found for NT. Among ecological areas, significant positive effects of CA practices were found in areas with an annual precipitation below 600 mm. Similar effects were found in areas with annual mean air temperature above 5 °C. For cropping regions, CA increased crop yield by 6.4% and 5.5%compared to CT in Northwest and South China, respectively, whereas no significant effects were found in the North China and Northeast China regions. Among crops, the positive effects of CA practices were significantly higher in maize(7.5%) and rice(4.1%) than in wheat(2.9%). NT likely decreased wheat yield. Our results indicate that there are great differences in the impacts of CA practices on crop yield, owing to regional variation in climate and crop types. CA will most likely increase maize yield but reduce wheat yield. It is strongly recommended to apply CA with crop straw retention in maize cropping areas and seasons with a warm and dry climate pattern. | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，2，5： | 15 |
| 3 | Monoclonal Antibody-Based Enzyme Linked Immunosorbent Assay for the Analysis of Jasmonates in Plants显示文摘Methyl jasmonate (MeJA) and its free-acid form, jasmonic acid (JA) are naturally occurring plant growth regulators widely distributed in higher plants. In order to improve the sensitivity for the analysis of MeJA at low levels in small amounts of plant samples, a monoclonal antibody (MAb) (designated as MAb 3E5D7C4B6) against MeJA was derived from a JA-bovine serum albumin (BSA) conjugate as an immunogen. The antibody belongs to the IgG1 subclass with a κ type light chain and has a dissociation constant of approximately 6.07 × 10?9 M. MAb3E5D7C4B6 is very specific to MeJA. It was used to develop a direct competitive enzyme-linked immunosorbent assay (dcELISA), conventional and simplified indirect competitive ELISAs (icELISA). JA was derivatized into MeJA for the ELISA analysis. The IC50 value and detection range for MeJA were, respectively, 34 and 4-257 ng/mL by the conventional icELISA, 21 and 3-226 ng/mL by the simplified icELISA and 5.0 and 0.7-97.0 ng/mL by the dcELISA. The dcELISA was more sensitive than either the conventional or simplified icELISA. The assays were used to measure the content of jasmonates as MeJA in tobacco leaves under drought stress or inoculated with tobacco mosaic virus and tomato leaves inoculated with tomato mosaic virus or Lirioinyza sativae Blanchard as compared with the corresponding healthy leaves. The increased jasmonates content indicated its role in response to the drought stress and pathogens. | Aixing Deng Weiming Tan Suping He Wei Liu Tiegui Nan Zhaohu Li Baomin Wang Qing X. Li | 2008 | Journal of Integrative Plant Biology2008，50，8： | 9 |
| 4 | Organic amendments increase corn yield by enhancing soil resilience to climate change显示文摘A 22-year field experiment was conducted in Gongzhuling, Jilin province, China to investigate corn yield response to fertilization practice. Compared to an unfertilized control(CK), all fertilization treatments, including inorganic nitrogen fertilizer only(N), balanced inorganic fertilizers(NPK), NPK plus corn straw(SNPK), and NPK plus farmyard manure(MNPK), resulted in significant increases in corn yield. However, only organic matter amendments sustained increasing yield trends, with annual rates of 0.137 and 0.194 t ha-1for the SPNK and MNPK treatments, respectively(P < 0.05). During the 22 years, the daily mean, maximum and minimum temperatures increased by 0.50, 0.53, and 0.46 °C per decade, whereas precipitation displayed no significant change but showed large seasonal variation. According to a regression analysis, increased air temperature exerted positive effects on corn yields under the SNPK and the MNPK treatments. Under both treatments,soil organic carbon contents and soil nutrient availabilities increased significantly compared to their initial levels in 1990, whereas soil bulk density and total porosity changed slightly under the two treatments, which showed higher soil water storage than other treatments. In contrast, significant increases in soil bulk density and decreases in soil total porosity and soil nutrient availability were observed under the CK, N and NPK treatments. The contributions of soil fertility to corn yield were 28.4%, 37.9%, 38.4%, 39.0%,and 42.9% under CK, N, NPK, SNPK, and MNPK treatments, respectively, whereas climate changes accounted for 27.0%, 14.6%, 12.4%, 11.8%, and 10.8%. These results indicate that, in Northeast China, organic matter amendments can mitigate negative and exploit positive effects of climate change on crop production by enhancing soil quality. | Zhenwei Song Hongjun Gao Ping Zhu Chang Peng Aixing Deng Chengyan Zheng Md Abdul Mannaf Md Nurul Islam Weijian Zhang | 2015 | The Crop Journal2015，3，2： | 8 |
| 5 | Cropping system innovation for coping with climatic warming in China显示文摘China is becoming the largest grain producing and carbon-emitting country in the world,with a steady increase in population and economic development.A review of Chinese experiences in ensuring food self-sufficiency and reducing carbon emission in the agricultural sector can provide a valuable reference for similar countries and regions.According to a comprehensive review of previous publications and recent field observations,China has experienced on average a larger and faster climatic warming trend than the global trend,and there are large uncertainties in precipitation change,which shows a non-significantly increasing trend.Existing evidence shows that the effects of climatic warming on major staple crop production in China could be markedly negative or positive,depending on the specific cropping region,season,and crop.However,historical data analysis and field warming experiments have shown that moderate warming,of less than2.0 °C,could benefit crop production in China overall.During the most recent warming decades,China has made successful adaptations in cropping systems,such as new cultivar breeding,cropping region adjustment,and cropping practice optimization,to exploit the positive rather than to avoid the negative effects of climatic warming on crop growth.All of these successful adaptations have greatly increased crop yield,leading to higher resource use efficiency as well as greatly increased soil organic carbon content with reduced greenhouse gas emissions.Under the warming climate,China has not only achieved great successes in crop production but also realized a large advance in greenhouse gas emission mitigation.Chinese experiences in cropping system innovation for coping with climatic warming demonstrate that food security and climatic warming mitigation can be synergized through policy,knowledge,and technological innovation.With the increasingly critical status of food security and climatic warming,further efforts should be invested in new agricultural policy,knowledge and technology creation,and popularization of climate-smart agriculture,and more financial investments should be made in field infrastructure development to increase cropping system resilience in China. | Aixing Deng Changqing Chen Jinfei Feng Jin chen Weijian Zhang | 2017 | The Crop Journal2017，5，2： | 7 |
| 6 | CNC FLEXIBLE GENERATING SPECIFIC GEAR TOOTH PROFILE BASED ON STANDARD INVOLUTE GEAR HOB显示文摘A new method named orthogonal two-way link-shift here has been proposed. Based on the method and a standard involute gear hob, a specific gear tooth profile (including an arbitrary gear tooth profile and a modified involute gear tooth profile) can be generated on a CNC(computer numerical control) hobbing machine. Computer simulation has been carried out, and the results prove that the method is right and practicable. So, the fabrication costs can be greatly decreased than before. The new method has momentous significance to realize gear's optimized modification under different work conditions. | FengXianying LiHui AiXing | 2004 | Chinese Journal of Mechanical Engineering2004，17，3： | 6 |
| 7 | Long-term inorganic plus organic fertilization increases yield and yield stability of winter wheat显示文摘An understanding of wheat yield and yield stability response to fertilization is important for sustainable wheat production. A 36-year long-term fertilization experiment was employed to evaluate the yield and yield stability of winter wheat. Five fertilization regimes were compared,including(1) CK, no fertilizer;(2) NPK, inorganic fertilizer only;(3) O, organic fertilizer only;(4)NPKO, 50% of NPK plus 50% of O, and(5) HNPKO, 80% of NPK plus 80% of O. The greatest yield increase was recorded in HNPKO, followed by NPKO, with O producing the lowest mean yield increase. Over the 36 years, the rate of wheat yield increase in fertilized plots ranged from95.31 kg ha-1 year-1 in the HNPKO to 138.65 kg ha-1 year-1 in the O. Yield stability analysis using the additive main effects and multiplicative interactions(AMMI) method assigned 62.3%, 26.3%,and 11.4% of sums of squares to fertilization effect, environmental effect, and fertilization ×environment interaction effect, respectively. The combination of inorganic and organic fertilization(NPKO and HNPKO) appeared to produce more stable yields than O or NPK, with lower coefficients of variation and AMMI stability value. However, wheat grown with O seemed to be the most susceptible to climate change and the least productive among the fertilized plots.Significant correlations of grain yield with soil properties and with mean air temperature were observed. These findings suggest that inorganic + organic fertilizer can increase wheat yield and its stability by improvement in soil fertility and reduction in variability to climate change. | Huan Chen Aixing Deng Weijian Zhang Wei Li Yuqiang Qiao Taiming Yang Chengyan Zheng Chengfu Cao Fu Chen | 2018 | The Crop Journal2018，6，6： | 5 |
| 8 | Realization of directional single-mode lasing by a GaN-based warped microring显示文摘Multimode and random directionalities are major issues restricting the application of whispering gallery mode microcavity lasers.We demonstrated a 40μm diameter microring with an off-centered embedded hole and warped geometry from strained III-nitride quantum well multilayers.Single-mode directional whispering gallery mode lasing was achieved by the warped structure and high-order mode suppression induced by the off-centered hole.In addition,the introduction of the off-centered hole reduced the lasing threshold from 3.24 to 2.79 MW/cm^(2) compared with the warped microdisk without an embedded hole while maintaining a high-quality factor of more than 4000.Directional light emission in 3D was achieved and attributed to the warped structure,which provides a vertical component of the light emission,making it promising for building multifunctional coherent light sources in optoelectronic integration. | Shengnan Zhang Yufeng Li Peng Hu Zhenhuan Tian Qiang Li Aixing Li Ye Zhang Feng Yun | 2021 | Photonics Research2021，9，4： | 2 |
| 9 | Connexin43downregulationanddephosphoryla-tioninnonischemicheartfailureisassociatedwithenhancedcolo-calizedproteinphosphatasetype2A显示文摘 | AiX PogwizdSM | 2005 | CircRes2005，96，1： | 1 |
| 10 | Impacts of planting systems on soil moisture, soil temperature and corn yield in rainfed area of Northeast China显示文摘 | Zhenwei Song Jinrui Guo Zhenping Zhang Taiji Kou Aixing Deng Chengyan Zheng Jun Ren Weijian Zhang | 2013 | European Journal of Agronomy2013，，： | 1 |
| 11 | Identification of erylltype genes from bacillus thuringiensis strainsand characterization of a novel erylI-type gene显示文摘 | Fuping Song Jie Zhang Aixing Gu | 2003 | Applied and Environmental Microbiol- ogy2003，69，9： | 1 |
| 12 | Will higher minimum temperatures increase corn production in Northeast China? An analysis of historical data over 1965–2008显示文摘 | Changqing Chen Chengxia Lei Aixing Deng Chunrong Qian Willem Hoogmoed Weijian Zhang | 2011 | Agricultural and Forest Meteorology2011，，12： | 1 |
| 13 | Identification of cry1I-type genes from Bacillus thuringiensis strains and characterization of a novel cry1 I-type gene显示文摘 | SONG FUPING ZHANG JIE GU AIXING | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 14 | Adult respiratory distress syndrome in full-term newborns显示文摘 | aix RG Viscardi RM Dipietro MA | 1989 | Pediatrcs1989，83，6： | 1 |
| 15 | Efficacy evaluation and mechanism of Bacillus subtilis EBS03 against cotton Verticillium wilt显示文摘Background:In our previous study,a strain EBS03 with good biocontrol potential was screened out of 48 strains of cotton endophyte Bacillus subtilis by evaluating the controlling effect against cotton Verticillium wilt.However,its mechanism for controlling Verticillium wilt remains unclear.The objective of this study was to further clarify its con-trolling effect and mechanism against cotton Verticillium wilt.Results:The results of confrontation culture test and double buckle culture test showed that the inhibitory effects of EBS03 volatile and nonvolatile metabolite on mycelium growth of Verticillium dahliae were 70.03%and 59.00%,respectively;the inhibitory effects of sporulation and microsclerotia germination were 47.16%and 70.06%,respec-tively.In the greenhouse test,the EBS03 fermentation broth root irrigation had the highest controlling effect at 87.11%on cotton Verticillium wilt,and significantly promoted the growth of cotton seedlings.In the field experi-ment,the controlling effect of EBS03 fermentation broth to cotton Verticillium wilt was 42.54%at 60 days after cotton sowing,and the boll number per plant and boll weight in EBS03 fermentation broth seed soaking,root irrigation,and spraying treatments significantly increased by 19.48%and 7.42%,30.90%and 2.62%,15.99%and 9.20%,respec-tively.Furthermore,EBS03 improved the resistance of cotton leaves against the infection of V.dahliae,and induced the outbreak of reactive oxygen species and accumulation of callose.In addition,the results of real time fluorescent quantitative polymerase chain reaction(RT-qPCR)detection showed that EBS03 significantly induced upregulation expression level of defense-related genes PAL,POD,PPO,and PR10 in cotton leaves,enhanced cotton plant resistance to V.dahliae,and inhibited colonization level of this fungal pathogen in cotton.Conclusion:Bacillus subtilis EBS03 has a good biological defense capability,which can inhibit the growth and coloni-zation level of V.dahliae,and activate the resistance of cotton to Verticillium wilt,thus increase cotton yield. | BAI Hongyan FENG Zili ZHAO Lihong FENG Hongjie WEI Feng ZHOU Jinglong GU Aixing ZHU Heqin PENG Jun ZHANG Yalin | 2022 | Journal of Cotton Research2022，5，4： | 1 |
| 16 | SJES14110700524164显示文摘 | Chengyan Zheng Yu Jiang Changqing Chen Yanni Sun Jinfei Feng Aixing Deng Zhenwei Song Weijian Zhang | 2014 | The Crop Journal2014，，5： | 1 |
| 17 | Clinical value of PET/CT's SUV, at baseline, early follow-up,and end of treatment reevaluation as a prognostic factor in small cell lung cancer patients with extended disease 显示文摘 | Aix SP Kopp RM Sepulveda JM | 2013 | ] Clin On- col2013，，： | 1 |
| 18 | Will higher minimum temperatures increase corn production in NortheastChina? An analysis of historical data over 1965-2008显示文摘 | Chen Changqing Lei Chengxia Deng Aixing | 2011 | Agri- cultural and Forest Meteorology2011，151，12： | 1 |
| 19 | Will higher minimum temperatures increase corn production in Northeast China? An analysis of historical data over 1965–2008显示文摘 | Changqing Chen Chengxia Lei Aixing Deng Chunrong Qian Willem Hoogmoed Weijian Zhang | 2011 | Agricultural and Forest Meteorology2011，，12： | 1 |
| 20 | Novel method for dynamic optimization of stability in high-speed milling system显示文摘 | SONGQinghua WANYi AiXing | 2009 | Transactions of Nanjing University of Aeronautics &Astronautics2009，，26： | 1 |
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