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| 1 | Antibacterial activity of Rosmarinus officinalis L.alone and in combination with cefuroxime against methicillin-resistant Staphylococcus aureus显示文摘Objective:To determine the antimicrobial activity of rosemary(Rosmarinus of ficinalis L.) and to investigate the synergistic effects of this extract combined with ceforuxime against methicillinresistant Staphylococcus aureus(MRSA).Methods:The inhibitory and bactericidal activities of rosemary ethanol extract,alone and in combination with cefuroxime,were studied.Results:The minimum inhibitory concentrations(MICs) of the ethanol extract of rosemary were in the range of 0.39-3.13 mg/mL.The minimum bactericidal concentrations(MBCs) were usually equal to or double that MICs.The antimicrobial activity of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic effects against all MRSAs.Conclusions:The present work clearly demonstrates that rosemary has a key role in the elevation of susceptibility toβ-lactams. | Naser Jarrar Awni Abu-Hijleh Kamel Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 10 |
| 2 | Antibacterial activities of some plant extracts alone and in combination with different antimicrobials against multidrug-resistant Pseudomonas aeruginosa strains显示文摘Objective:To evaluate the possible in vitro interaction between ethanolic extracts of Rhus coriaria[R.coriaria)(seed),Sacropoterium spinosum(S.spinosum)(seed),Rosa damascena(R. damascene)(flower) and certain known antimicrobial drugs including oxytetracycline HCl, penicillin C,cephalexin,sulfadimethoxine as sodium,and enr of loxacin.This synergy study was carried out against 3 clinical strains of multidrug-resistant Pseudomonas aeruginosa (P.aeruginosa).Methods:Evaluation of synergy interaction between plant extracts and antimicrobial agents was carried out using microdilution method.Results:The results of this study showed that there is a decrease in the MIC in case of combination of ethanolic plant extracts and test antimicrobial agents.The most interesting result was that the combination between R. coriaria and these antibiotics,showed a high decrease in minimum inhibitory concentration(MIC), and a strong bactericidal activity against these strains.Conclusions:These results may indicate that combinations between R.coriaria extract and these antibiotics could be useful in fighting emerging drug-resistance P.aeruginosa,which may due to that R.coriaria extract contain natural inhibitors working by different mechanisms or inhibiting efflux pumps.Now we have experiments underway leading to the identification of the active molecules present in R.coriaria.Further,in vivo experiments are needed to confirm pseudomonal protection. | Ghaleb Adwan Bassam Abu-Shanab Kamel Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 4 |
| 3 | Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans显示文摘Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients. | Ghaleb Adwan Yousef Salameh Kamel Adwan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 3 |
| 4 | Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans显示文摘Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.albicans) isolates.Methods:The antifungal activity of these toothpaste formulations was determined using a standard agar well diffusion method.Statistical analysis was performed using a statistical package,SPSS windows version 15,by applying mean values using one-way ANOVA with post-hoc least square differences(LSD) method.A P value of less than 0.05 was considered significant.Results:All toothpastes studied in our experiments were effective in inhibiting the growth of all C.albicans isolates.The highest anticandidal activity was obtained from toothpaste that containing both herbal extracts and sodium fluoride as active ingredients, while the lowest activity was obtained from toothpaste containing sodium monofluorophosphate as an active ingredient.Antifungal activity of Parodontax toothpaste showed a significant difference(P<0.001) against C.albicans isolates compared to toothpastes containing sodium fluoride or herbal products.Conclusions:In the present study,it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C.albicans,while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C.albicans.Some herbal toothpaste formulations studied in our experiments,appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products.Our results may provide invaluable information for dental professionals. | Ghaleb Adwan Yousef Salameh Kamel Adwan Ali Barakat | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 3 |
| 5 | Synergistic effects of plant extracts and antibiotics on Staphylococcus aureus strains isolated from clinical specimens显示文摘Objective:This study has been done to evaluate the interaction between water extracts of Psidium guajava, Rosmarinus officinalis,Salvia fruticosa,Majorana syriaca,Ocimum basilucum,Syzygium aromaticum,Laurus nobilis,and Rosa damascena alone and then synergy testing of these extracts with known antimicrobial agents including oxytetracycline HCl,gentamicin sulfate,penicillin G,cephalexin and enrofloxacin.This study was conducted against five S.aureus isolates;one is Methicillin -resistant Staphylococcus aureus(MRSA) and 4 Methicillin - sensitive Staphylococcus aureus(MSSA).Methods:Evaluation of the interaction between plant extracts and different antimicrobial agents has been done using well - diffusion and microdilution methods. Results:The results of the conducted experiments using well - diffusion method demonstrate that these plants showed in vitro interactions between antimicrobial agents and plant extracts were additive,while using microdilution method showed synergistic effects with significant reduction in the MICs of the test antibiotics against these strains of S.aureus.This change in MIC was noticed in all plant extracts against test antibiotics including these plants showed weak antibacterial activity by well diffusion method.Synergism effect was occurred in both sensitive and resistant strains but the magnitude of minimum fold reduction of inhibitory concentration in resistant strains especially MRSA strain was higher than the sensitive strains.Coclusion:This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S.aureus strains or at least the concomitant administration may not impair the antimicrobial activity of these antibiotics. | Ghaleb Adwan Mohammad Mhanna | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 6 | Gentamicin resistance in clinical strains ofEnterobacteriaceae associated with reduced gentamicin uptake显示文摘 | K. Adwan N. Abu-Hasan | 1998 | Folia Microbiologica1998，，4： | 2 |
| 7 | The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasis显示文摘 | Georges R B Adwan H Hamdi H | 2011 | Cancer Biol Ther2011，12，1： | 1 |
| 8 | Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease 显示文摘 | ADWAN L ZAWIA N H | 2013 | Pharmacol Ther2013，139，1： | 1 |
| 9 | The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasis显示文摘 | Georges R B Adwan H Hamdi H | | 0，，01： | 1 |
| 10 | Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma显示文摘 | Adwan H Zhivkova-Galunska M Georges R | | 0，，2： | 1 |
| 11 | Osteonectin influ-ences growth and invasion of pancreatic cancer cells显示文摘 | Guweidhi A Kleeff J Adwan H | | 0，，2： | 1 |
| 12 | Larval stages of digenetic trematodes in Melanopsis praemorsa snails from freshwater bodies in Palestine显示文摘Objective:To detect the species of larval trematodes(cercariae) in Melanopsis praemorsa snails from 5 different fresh water bodies in Palestine.Methods:A total of 1 880 Melanopsis praemona snails were collected from different fresh water bodies in Palestine from October,2008 to November,2010.Cercariae in Melanopsis praemona snails were obtained by lighting and crushing methods.The behavior of cercariae was observed using a dissecting microscope.Results:Three different species of larval trematodes were identified from Melanopsis praemona snails collected only from Al-Bathan fresh water body,while snails from other water bodies were not infected. These species were microcercous cercaria,xiphidiocercaria and brevifurcate lophocercous cercaria.These cercariae called Cercaria melanopsi palestinia 1,Cercaria melanopsi palestinia H and Cercaria melanopsi palestinia III have not been described before from this snail in Palestine. The infection rate of Melanopsis praemona collected from Al-Bathan fresh water body was 5.7%, while the overall infection rate of snails collected from all fresh water bodies was 4.3%.Details are presented on the morphology and behavior of the cercariae as well as their development within the snail.Conclusions:These results have been recorded for the first time and these cercariae may be of medical and veterinary importance. | Sami Bdir Ghaleb Adwan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 1 |
| 13 | The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasis显示文摘 | Georges RB Adwan H Hamdi H | | 0，，01： | 1 |
| 14 | Tolfenamic acid re-duces Tau and CDK5 levels: implications for dementia andTauopathies显示文摘 | Adwan L Subaiea GM Basha R et aL | 2014 | J Neurochem2014，，： | 1 |
| 15 | Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231breast cancer cells and its application to the effects of an antibody against bone sialoprotein显示文摘 | Bauerle T Adwan H Kiessling F | 2005 | Int J Cancer2005，115，2： | 1 |
| 16 | Riproximin: A type II ribosome inactivating protein with anti-neoplasticpotential induces IL24/MDA-7 and GADD genes in colorectal cancer cell lines显示文摘 | Asim Pervaiz Hassan Adwan Martin Berger | 2015 | International Journal of Oncology2015，，3： | 1 |
| 17 | Downregulation of osteopontin and bone sialoprotein Ⅱ is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells显示文摘 | Adwan H Bauerle T J Berger M R | 2004 | Cancer Gene Ther2004，11，2： | 1 |
| 18 | Sustained delivery and ef- ficacy of polymeric nanopartieles containing osteopontin and bone sialoprotein ant/senses in rats with breast cancer bone me- tastasis显示文摘 | Elazar V Adwan H Bauerle T | 2010 | Int J Cancer2010，126，7： | 1 |
| 19 | Sustained delivery and efficacy of polymeric nanoparticles containing osteopontin and bone sialoprotein antisenses in rats with breast cancer bone metastasis 显示文摘 | Elazar V Adwan H Bauerle T | 2010 | Int J Cancer2010，126，7： | 1 |
| 20 | Osteonectin influencesgrowth and invasion of pancreatic cancer cells显示文摘 | Guweidhi A Kleeff J Adwan H | 2005 | Ann Surq2005，242，2： | 1 |
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