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| 1 | Antibacterial activities of some plant extracts alone and in combination with different antimicrobials against multidrug-resistant Pseudomonas aeruginosa strains显示文摘Objective:To evaluate the possible in vitro interaction between ethanolic extracts of Rhus coriaria[R.coriaria)(seed),Sacropoterium spinosum(S.spinosum)(seed),Rosa damascena(R. damascene)(flower) and certain known antimicrobial drugs including oxytetracycline HCl, penicillin C,cephalexin,sulfadimethoxine as sodium,and enr of loxacin.This synergy study was carried out against 3 clinical strains of multidrug-resistant Pseudomonas aeruginosa (P.aeruginosa).Methods:Evaluation of synergy interaction between plant extracts and antimicrobial agents was carried out using microdilution method.Results:The results of this study showed that there is a decrease in the MIC in case of combination of ethanolic plant extracts and test antimicrobial agents.The most interesting result was that the combination between R. coriaria and these antibiotics,showed a high decrease in minimum inhibitory concentration(MIC), and a strong bactericidal activity against these strains.Conclusions:These results may indicate that combinations between R.coriaria extract and these antibiotics could be useful in fighting emerging drug-resistance P.aeruginosa,which may due to that R.coriaria extract contain natural inhibitors working by different mechanisms or inhibiting efflux pumps.Now we have experiments underway leading to the identification of the active molecules present in R.coriaria.Further,in vivo experiments are needed to confirm pseudomonal protection. | Ghaleb Adwan Bassam Abu-Shanab Kamel Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 4 |
| 2 | Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans显示文摘Objective:To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium(E. elaterium)fruits alone against Staphylococcus aureus(S.aureus) strains and Candida albicans(C.albicans)strains,or in combination with penicillin against Staphylococcus areus strains. Methods:Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.Results:The results showed that ethanolic extract of E.elaterium fruits has antimicrobial activity against methicillin resistant S.aureus(MRSA),methicillin sensitive S. aureus(MSSA) and C.albicans.This extract showed a significant decrease in minimum inhibitory concentrations(MIC)of penicillin against both MRSA and MSSA strains.Fractional inhibitory concentration index(FIC)between penicillin and ethanolic extract of E.elaterium fruits against these test strains was less than 0.5.Conclusions:This study suggests that ethanolic extract of E.elaterium fruits has antimicrobial activity against S.aureus and C.albicans and there is a possibility of concurrent use of penicillin and E.elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains.A wider study is needed to identify the effective components,the mode of action and the possible toxic effect in vivo of these ingredients. | Ghaleb Adwan Yousef Salameh Kamel Adwan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 3 |
| 3 | Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans显示文摘Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.albicans) isolates.Methods:The antifungal activity of these toothpaste formulations was determined using a standard agar well diffusion method.Statistical analysis was performed using a statistical package,SPSS windows version 15,by applying mean values using one-way ANOVA with post-hoc least square differences(LSD) method.A P value of less than 0.05 was considered significant.Results:All toothpastes studied in our experiments were effective in inhibiting the growth of all C.albicans isolates.The highest anticandidal activity was obtained from toothpaste that containing both herbal extracts and sodium fluoride as active ingredients, while the lowest activity was obtained from toothpaste containing sodium monofluorophosphate as an active ingredient.Antifungal activity of Parodontax toothpaste showed a significant difference(P<0.001) against C.albicans isolates compared to toothpastes containing sodium fluoride or herbal products.Conclusions:In the present study,it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C.albicans,while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C.albicans.Some herbal toothpaste formulations studied in our experiments,appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products.Our results may provide invaluable information for dental professionals. | Ghaleb Adwan Yousef Salameh Kamel Adwan Ali Barakat | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 3 |
| 4 | Synergistic effects of plant extracts and antibiotics on Staphylococcus aureus strains isolated from clinical specimens显示文摘Objective:This study has been done to evaluate the interaction between water extracts of Psidium guajava, Rosmarinus officinalis,Salvia fruticosa,Majorana syriaca,Ocimum basilucum,Syzygium aromaticum,Laurus nobilis,and Rosa damascena alone and then synergy testing of these extracts with known antimicrobial agents including oxytetracycline HCl,gentamicin sulfate,penicillin G,cephalexin and enrofloxacin.This study was conducted against five S.aureus isolates;one is Methicillin -resistant Staphylococcus aureus(MRSA) and 4 Methicillin - sensitive Staphylococcus aureus(MSSA).Methods:Evaluation of the interaction between plant extracts and different antimicrobial agents has been done using well - diffusion and microdilution methods. Results:The results of the conducted experiments using well - diffusion method demonstrate that these plants showed in vitro interactions between antimicrobial agents and plant extracts were additive,while using microdilution method showed synergistic effects with significant reduction in the MICs of the test antibiotics against these strains of S.aureus.This change in MIC was noticed in all plant extracts against test antibiotics including these plants showed weak antibacterial activity by well diffusion method.Synergism effect was occurred in both sensitive and resistant strains but the magnitude of minimum fold reduction of inhibitory concentration in resistant strains especially MRSA strain was higher than the sensitive strains.Coclusion:This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S.aureus strains or at least the concomitant administration may not impair the antimicrobial activity of these antibiotics. | Ghaleb Adwan Mohammad Mhanna | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 5 | Larval stages of digenetic trematodes in Melanopsis praemorsa snails from freshwater bodies in Palestine显示文摘Objective:To detect the species of larval trematodes(cercariae) in Melanopsis praemorsa snails from 5 different fresh water bodies in Palestine.Methods:A total of 1 880 Melanopsis praemona snails were collected from different fresh water bodies in Palestine from October,2008 to November,2010.Cercariae in Melanopsis praemona snails were obtained by lighting and crushing methods.The behavior of cercariae was observed using a dissecting microscope.Results:Three different species of larval trematodes were identified from Melanopsis praemona snails collected only from Al-Bathan fresh water body,while snails from other water bodies were not infected. These species were microcercous cercaria,xiphidiocercaria and brevifurcate lophocercous cercaria.These cercariae called Cercaria melanopsi palestinia 1,Cercaria melanopsi palestinia H and Cercaria melanopsi palestinia III have not been described before from this snail in Palestine. The infection rate of Melanopsis praemona collected from Al-Bathan fresh water body was 5.7%, while the overall infection rate of snails collected from all fresh water bodies was 4.3%.Details are presented on the morphology and behavior of the cercariae as well as their development within the snail.Conclusions:These results have been recorded for the first time and these cercariae may be of medical and veterinary importance. | Sami Bdir Ghaleb Adwan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 1 |
| 6 | Prevalence of intestinal parasitic infections in Jenin Governorate,Palestine:a 10-year retrospective study显示文摘Objective:To assess the prevalence of intestinal parasites among Jenin Govemorate(Northern Palestine) population.Methods:A retrospective laboratory analysis of stool specimens was carried out for intestinal parasite examination in Jenin Governmental Hospital,Jenin Govemorate,Northern Palestine.The records were collected from the clinical microbiology laboratory of the Jenin Governmental Hospital between January 2000 and December 2009. Results:Our retrospective study showed that the prevalence of intestinal parasite infection during 10 years ranged from 32.0-41.5%.There are at least 7 different parasites encountered.The most common pathogenic parasites identified were:Entamoeba histolytica(8.2-18.2%),Enterobius vermicularis(15.6-28.9%).The other parasites present were Giardia lamblia,Ascaris lumbricoides, Strongyloides stercoralis,Taenia species and Ancylostoma duodenale.(Hookworms).Conclusions: Intestinal parasitic infection is an important public health problem in Jenin govemorate, Palestine.It is necessary to develop effective prevention and control strategies including health education and environmental sanitation improvement. | Sami Bdir Ghaleb Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 1 |
| 7 | Three new species of cercariae from Melanopsis praemorsa (L. 1758, Buccinum) snails in Al-Bathan fresh water body, Palestine显示文摘 | Sami Bdir Ghaleb Adwan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，2： | 1 |
| 8 | Molecular characterization and phylogenetic analysis of Middle East 2009 H1N1 pdm isolates显示文摘Objective:To study hemagglutinin genetic evolution of some Middle East(ME) 2009 H1N1 pdm isolates and compared them with prototype vaccine strain[A/California/07/2009(H1N1)],which is used as a vaccine strain in the Northern Hemisphere 2010-2011.Methods:Nucleotide and/ or amino acid sequences of HA gene of fifty-four ME 2009 H1N1 pdm isolates were retrieved from GenBank Database by using Basic BLAST engine.Phylogenetic trees were established for both nucleotide and amino acid sequences using the muscle algorithm of the computer program CLC free workbench 5.6.1 JRE software.Amino acids alignment was also done to compare sequences HA1 domains of HA genes of ME 2009 H1N1 pdm isolates(n=39) with amino acid sequence of prototype vaccine strain A/California/07/2009(H1N1).Results:Phylogenetic analysis of amino acids and nucleotides of the HA gene of the ME 2009 H1N1 pdm isolates confirmed their evolutionary position in cluster with prototype vaccine strain(A/California/07/2009(H1N1)) which is used as vaccine strain in the Northern Hemisphere 2010-2011.Antigenically,the ME 2009 H1N1 pdm isolates were homogeneous and closely related to prototype vaccine.Only a few amino acid substitutions in the HA among the ME 2009 H1N1 pdm isolates were analyzed.Conclusions: The current influenza vaccine is expected to provide a good protection against ME 2009 H1N1 pdm because it contains strains with H1HA[A/California/07/2009(H1N1)]-like strain. | Ghaleb Adwan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 0 |
| 9 | Deep Learning and Machine Learning for Early Detection of Stroke and Haemorrhage显示文摘Stroke and cerebral haemorrhage are the second leading causes of death in the world after ischaemic heart disease.In this work,a dataset containing medical,physiological and environmental tests for stroke was used to evaluate the efficacy of machine learning,deep learning and a hybrid technique between deep learning and machine learning on theMagnetic Resonance Imaging(MRI)dataset for cerebral haemorrhage.In the first dataset(medical records),two features,namely,diabetes and obesity,were created on the basis of the values of the corresponding features.The t-Distributed Stochastic Neighbour Embedding algorithm was applied to represent the high-dimensional dataset in a low-dimensional data space.Meanwhile,the Recursive Feature Elimination algorithm(RFE)was applied to rank the features according to priority and their correlation to the target feature and to remove the unimportant features.The features are fed into the various classification algorithms,namely,Support Vector Machine(SVM),K Nearest Neighbours(KNN),Decision Tree,Random Forest,and Multilayer Perceptron.All algorithms achieved superior results.The Random Forest algorithm achieved the best performance amongst the algorithms;it reached an overall accuracy of 99%.This algorithm classified stroke cases with Precision,Recall and F1 score of 98%,100%and 99%,respectively.In the second dataset,the MRI image dataset was evaluated by using the AlexNet model and AlexNet+SVM hybrid technique.The hybrid model AlexNet+SVM performed is better than the AlexNet model;it reached accuracy,sensitivity,specificity and Area Under the Curve(AUC)of 99.9%,100%,99.80%and 99.86%,respectively. | Zeyad Ghaleb Al-Mekhlafi Ebrahim Mohammed Senan Taha H.Rassem Badiea Abdulkarem Mohammed Nasrin M.Makbol Adwan Alownie Alanazi Tariq S.Almurayziq Fuad A.Ghaleb | 2022 | Computers, Materials & Continua2022，，7： | 0 |
| 10 | Emergence of vancomycin-intermediate resistant Staphylococcus aureus in north of Palestine显示文摘Objective:This study was conducted to update the prevalence of methicillin-resistant Staphylococcus aureus(MRSA) isolates among human clinical S.aureus isolates recovered from Northern Palestine,to evaluate the possible presence of vancomycin-Resistant S.aureus(VRSA) and vancomycin- intermediate resistant S.aureus strains(VISA) and to determine the antimicrobial susceptibilities of these clinical isolates.Methods:The in vitro activities of 11 antibiotics against 204 non-duplicate S.aureus isolates from clinical samples in North of Palestine were determined by the diskdiffusion method.These samples were isolated between June 2006 and December 2007.The minimum inhibitory concentration (MIC) of vancomycin for 115 methicillin resistant Staphylococcus aureus(MRSA) strains was carried out using the agar dilution method.Results:One hundred and fifteen(56.4%) of these isolates were MRSA and according to their antibiotic profile these are multidrug resistant(resistant to three or more non-p-lactam antibiotics). Ninety nine(43.6%) isolates were methicillin sensitive S.aureus(MSSA),forty four of MSSA isolates(44.4%) were multidrug resistant,while forty five(45.6%) were non multidrug resistant.Our results showed that the most common resistance(95.6%) was to penicillin.Two strains of MRSA have shown to be vancomycin- intermediate resistant,had MIC of 4μg/rnL and 8μg/mL and these vancomycin- intermediate resistant S.aureus strains(VISA) are resistant to all antibiotics tested.Conclusion:According to our information this is the first study report about VISA in Palestine. | Ghaleb Adwan Bassam Abu-Shanab Marwan Odeh | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，5： | 0 |
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