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| 1 | 精氨酸:生物化学、生理学及治疗学意义显示文摘目前营养学进展已集中在单个氨基酸的药理学作用及其器官特异性作用研究方面。有关精氨酸,已有大量工作研究了其作为治疗药物时的作用。精氨酸的生物化学所有的机体组织利用精氨酸合成细胞浆蛋白和核蛋白;精氨酸也是脒的的提供者,用于合成胍基乙酸,进而合成肌酸。 | Adrian Barbul 郭长江 | 1987 | 氨基酸和生物资源1987，15，2： | 22 |
| 2 | GENERAL PRINCIPLES OF WOUND HEALING显示文摘 | Maria B. Witte Adrian Barbul | 1997 | Surgical Clinics of North America1997，，3： | 4 |
| 3 | HEALING IN THE GASTROINTESTINAL TRACT显示文摘 | Frank J. Thornton Adrian Barbul | 1997 | Surgical Clinics of North America1997，，3： | 2 |
| 4 | Role of β-Hydroxy β-Methylbutyrate (HMB) in Cancer Cachexia/ Sarcopenia显示文摘Cancer cachexia is a complex multifactorial syndrome that has a substantial impact on the quality of life of cancer patients. Although some treatment options exist to counteract cachexia, very few options counteract sarcopenia (loss of muscle mass). HMB may be a viable component in multi-modal approaches targeting treatment of cancer cachexia/sarcopenia. Evidence suggests that HMB promotes myogenic events, suppresses proteasome activity, and activates protein synthesis. HMB also represses inflammation, reduces tumor growth, and increases lifespan. | Hana Ajouz Amaury MartinezGarcia Adrian Barbul | 2019 | Journal of Nutritional Oncology2019，4，1： | 2 |
| 5 | Intra-abdominal sepsis impairs colonic reparative collagen synthesis显示文摘 | Gretchen M. Ahrendt Udaya S. Tantry Adrian Barbul | 1996 | The American Journal of Surgery1996，，： | 1 |
| 6 | Immunostimulatory effects of arginine in normal and injured rats 显示文摘 | Barbul Adrian Wasserkrug Hannah L Seifter Eli | 1980 | Journal of Surgical Research1980，29，3： | 1 |
| 7 | Repair of full-thickness bowel injury显示文摘 | Maria B. Witte Adrian Barbul | 2003 | Critical Care Medicine . 2003 (8 Su)2003，，8： | 1 |
| 8 | Arginine Metabolism in Cancer:A Valid Therapeutic Target?显示文摘Arginine is a conditionally essential amino acid that has been identified as an important player in a number of biologic processes,including normal functions of the cardiovascular and immune systems.Numerous studies have demonstrated that arginine is necessary for cellular growth and can become limiting in states of rapid growth like malignancy.Given this requirement for arginine in malignant cells,investigators have examined the potential for arginine deprivation therapy as an adjuvant treatment for cancers that are unable to synthesize arginine de novo.Additionally,arginine has been identified as being critically important for immune surveillance that targets and destroys malignant cells.Thus,paradoxically,arginine has been identified as being both necessary for cancer growth and normal immune destruction of malignant cells.A number of factors,including the type of cancer,expression of arginine synthetic genes,tumor microenvironment and host immune cell-cancer cell interactions,can affect the progression of malignancy.Herein we review the data supporting arginine deprivation and supplementation in cancer therapies and the currently registered trials that aim at understanding which of these strategies may lead to advances in cancer therapy. | Vance L. Albaugh Carolina Pinzon-Guzman Adrian Barbul | 2017 | Journal of Nutritional Oncology2017，2，1： | 0 |
| 9 | 特殊营养素与肿瘤(详见光盘)显示文摘癌症恶液质的定义是指一种以持续性的骨骼肌丢失(伴有或不伴有脂肪组织丢失)为特征,不能被常规营养支持完全逆转,并导致进行性功能损害的多因素综合征。其病理学特征表现为:低摄入量和代谢异常导致的蛋白及能量负平衡。一旦出现便有可能会影响治疗方案的实施,降低化疗的敏感性,增加治疗难度和相关治疗并发症的发生,严重影响患者生活质量,缩短生存期。 | Adrian Barbul | 2019 | 肿瘤代谢与营养电子杂志2019，6，1： | 0 |
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