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| 1 | Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease显示文摘AIM To compare transcriptomes of non-alcoholic fatty liver disease(NAFLD) and alcoholic liver disease(ALD) in a meta-analysis of liver biopsies.METHODS Employing transcriptome data from patient liver biopsies retrieved from several public repositories we performed a meta-analysis comparing ALD and NAFLD.RESULTS We observed predominating commonalities at the transcriptome level between ALD and NAFLD,most prominently numerous down-regulated metabolic pathways and cytochrome-related pathways and a few up-regulated pathways which include ECM-receptor interaction,phagosome and lysosome.However some pathways were regulated in opposite directions in ALD and NAFLD,for example,glycolysis was down-regulated in ALD and up-regulated in NAFLD.Interestingly,we found rate-limiting genes such as HMGCR,SQLE and CYP7A1 which are associated with cholesterol processes adversely regulated between ALD(down-regulated) and NAFLD(up-regulated).We propose that similar phenotypes in both diseases may be due to a lower level of the enzyme CYP7A1 compared to the cholesterol synthesis enzymes HMGCR and SQLE.Additionally,we provide a compendium of comparative KEGG pathways regulation in ALD and NAFLD.CONCLUSION Our finding of adversely regulated cholesterol processes in ALD and NAFLD draws the focus to regulation of cholesterol secretion into bile.Thus,it will be interesting to further investigate CYP7A1-mediated cholesterol secretion into bile-also as possible drug targets.The list of potential novel biomarkers may assist differential diagnosis of ALD and NAFLD. | Wasco Wruck James Adjaye | 2017 | World Journal of Hepatology2017，9，8： | 8 |
| 2 | The relationship between energy consumption, energy price and economic growth: time series evidence from Asian developing countries 显示文摘 | John Asafu- Adjaye | 2000 | Energy Economics2000，，22： | 1 |
| 3 | Kinetics of bitumen-derived gas oil upgrading using a commercial NiMo/Al2O3 catalyst显示文摘 | Botchwey C Dalai A K Adjaye J | | 0，，03： | 1 |
| 4 | Surface morphology of NiMo/Al2O3 catalysts incorporated with boron and phosphorus:experimental and simulation显示文摘 | Ferdous D Dalai A K Adjaye J | | 0，，： | 1 |
| 5 | Effect of EDTA on hydrotreating activity of CoMo/γ-Al2 O3 catalyst显示文摘 | SUNDARAMURTHY V DALAI A K ADJAYE J | 2005 | Catal Lett2005，102，34： | 1 |
| 6 | Product selectivity during hydrotreating and mild hydrocracking of bitumen-derived gas oil显示文摘 | Botchwey C Dalai A K Adjaye J | | 0，，05： | 1 |
| 7 | Ab initio DFT study of hydrogen dissociation on MoS2,NiMoS,and CoMoS:mechanism,kinetics,and vibrational frequencies 显示文摘 | Sun M Y Nelson A E Adjaye J | 2005 | Journal of Catalysis2005，233，2： | 1 |
| 8 | Surface mor- phology of NiMo/Al2O3 catalysts incorporated with boron and phosphorus : experimental and simulation 显示文摘 | Ferdous D Dalai A K Adjaye J | 2005 | Ap- plied Catalysis A : General2005，294，： | 1 |
| 9 | Effect of EDTA on hydrotreating activity of CoMo/r-A1203 catalyst显示文摘 | SUNDARAMURTHY V DALAI A K ADJAYE J | 2005 | Catal Lett2005，102，3： | 1 |
| 10 | Synthesis,characterization and performance of NiMo catalysts supported on titania modified alumina for the hydroprocessing of different gas oils derived from Athabasca bitumen 显示文摘 | Ferdous D Bakhshi N N Dalai A K Adjaye J | 2007 | Applied Catalysis B:Environmental2007，72，： | 1 |
| 11 | Energy Consumption,Economic Growth and Prices: A Reassessment using Panel VECM for Developed and Developing Countries 显示文摘 | MAHADEVAN R ASAFU - ADJAYE J | 2007 | Energy Policy2007，35，： | 1 |
| 12 | Comparison of hydrodenitrogenation of model basic and nonbasic nitrogen species in a trickle bed reactor using commercial NiMo/Al2O3 Catalyst显示文摘 | FERDOUS Deena DALAI A K ADJAYE J | 2003 | Energy & Fuels2003，17，1： | 1 |
| 13 | Application of muli-walled carbon nanotubes as efficient support to NiMo hydrotreating catalyst显示文摘 | ESWARAMOORTHI I SUNDARAMURTHY V DAS N DALAI A K ADJAYE J | 2008 | Appl Catal A2008，339，2： | 1 |
| 14 | The effect of phosphorus onhydrotreating property of NiMo/γ-Al2O3 nitride catalyst显示文摘 | Sundaramurthy V Dalai A K Adjaye J | 2008 | AppliedCatalysis A:General2008，335，2： | 1 |
| 15 | Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc显示文摘 | Geertrui Tavernier Katharina Wolfrum Joseph Demeester Stefaan C. De Smedt James Adjaye Joanna Rejman | 2011 | Biomaterials2011，，2： | 1 |
| 16 | Hydrodenitrogenation and hydrodesulfurization fo heavy gas oil using NiMo/Al2O3 catalyst containing boron: Experimental and kinetic studies显示文摘 | FERDOUS D DALAI A K ADJAYE J | 2006 | Ind Eng Chem Res2006，45，2： | 1 |
| 17 | On the incorporation of nickel and cobalt into MoS2-edge structures显示文摘 | Sun M Nelson A E Adjaye J | | 0，，01： | 1 |
| 18 | Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential显示文摘 | May Al-Nbaheen Radhakrishnan vishnubalaji Dalia Ali Amel Bouslimi Fawzi Al-Jassir Matthias Megges Alessandro Prigione James Adjaye Moustapha Kassem Abdullah Aldahmash | 2013 | Stem Cell Reviews and Reports2013，，1： | 1 |
| 19 | Catalytic conversion of a biomass-derived oil to fuels and chemicals Ⅰ:Model compound studies and reaction pathways显示文摘 | Adjaye J D Bakhshi N N | 1995 | Biomass and Bioenergy1995，8，3： | 1 |
| 20 | The relationship between electricity consumption, electricity prices and economic growth: time series evidence from Asian developing countries 显示文摘 | ASAFU ADJAYE J | 2000 | Energy Economics2000，22，： | 1 |
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