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| 1 | Therapeutics administered during ex vivo liver machine perfusion:An overview显示文摘Although the use of extended criteria donors has increased the pool of available livers for transplant,it has also introduced the need to develop improved methods of protection against ischemia-reperfusion injury(IRI),as these'marginal'organs are particularly vulnerable to IRI during the process of procurement,preservation,surgery,and post-transplantation.In this review,we explore the current basic science research investigating therapeutics administered during ex vivo liver machine perfusion aimed at mitigating the effects of IRI in the liver transplantation process.These various categories of therapeutics are utilized during the perfusion process and include invoking the RNA interference pathway,utilizing defatting cocktails,and administering classes of agents such as vasodilators,anti-inflammatory drugs,human liver stem cell-derived extracellular vesicles,and δ-opioid agonists in order to reduce the damage of IRI.Ex vivo machine perfusion is an attractive alternative to static cold storage due to its ability to continuously perfuse the organ,effectively deliver substrates and oxygen required for cellular metabolism,therapeutically administer pharmacological or cytoprotective agents,and continuously monitor organ viability during perfusion.The use of administered therapeutics during machine liver perfusion has demonstrated promising results in basic science studies.While novel therapeutic approaches to combat IRI are being developed through basic science research,their use in clinical medicine and treatment in patients for liver transplantation has yet to be explored. | Julianna E Buchwald Jing Xu Adel Bozorgzadeh Paulo N Martins | 2020 | World Journal of Transplantation2020，10，1： | 3 |
| 2 | Potential approaches to improve the outcomes of donation after cardiac death liver grafts显示文摘There is a growing discrepancy between the supply and demand of livers for transplantation resulting in high mortality rates on the waiting list. One of the options to decrease the mortality on the waiting list is to optimize organs with inferior quality that otherwise would be discarded. Livers from donation after cardiac death(DCD) donors are frequently discarded because they are exposed to additional warm ischemia time, and this might lead to primary-non-function, delayed graft function, or severe biliary complications. In order to maximize the usage of DCD livers several new preservation approaches have been proposed. Here, we will review 3 innovative organ preservation methods:(1) different ex vivo perfusion techniques;(2) persufflation with oxygen; and(3) addition of thrombolytic therapy. Improvement of the quality of DCD liver grafts could increase the pool of liver graft's for transplantation, improve the outcomes, and decrease the mortality on the waiting list. | Paria Mahboub Adel Bozorgzadeh Paulo N Martins | 2016 | World Journal of Transplantation2016，6，2： | 2 |
| 3 | Short-term effects of different fire severities on soil properties and Pinus halepensis regeneration显示文摘Considering that diverse fire severities can affect soil properties differently,the aim of this study was to examine to what extent changes in soil properties caused by fire could condition seedling establishment.This new approach is for identifying a new fire cause-effect chain to qualify the impacts of fire on soils with the purpose of using fire as a tool in forest management to favour Pinus halepensis Mill.regeneration.The study area was a reforested P.halepensis area which had been crossed by fire for78.8 ha,causing various degrees of damage.The forest was subdivided into three large areas according to the gravity of crown scorch,[low(LS),medium(MS)and high(HS)severity],on the basis of needle yellowing which usually occurs after exposure to direct flames.Results showed significant differences in soil properties with respect to fire severity.In the HS area,total nitrogen and carbon were considerably reduced while ash and phosphorus contents significantly increased.The changes in soil properties,in particular to nutrient levels,affected P.halepensis regeneration,mainly the first year after the fire.Greater regeneration occurred in areas affected by moderate fire severity in which the temperatures reached increased the mineralization of soil organic matter with the consequent release of nutrients available for seedling growth.Additionally,moderate fire severity suppressed the regeneration of grasses,reducing the interspecific competition.Heights of seedlings were inversely proportional to the density of grasses.Where the number was abundant(LS),the height was modest;conversely,where the number was low(HS),the greater hypsometric differentiation of pine seedlings was observed.These results suggest that moderate fire severity represents an environmental stress(hormesis)altering microscale conditions to increase pine germination and establishment.The exposure of P.halpensis to a moderate environmental factor that is damaging at higher intensities,induces an adaptive beneficial effect on seedling regeneration.This data can re-evaluate the assertion that coniferous burned areas,if left unmanaged,would remain unproductive for an indefinite period. | Federico Romeo Pasquale A.Marziliano Maria Belén Turrión Adele Muscolo | 2020 | Journal of Forestry Research2020，31，4： | 2 |
| 4 | Inhibition of hydroxyl-radical generated DNA degrdation by metallothionein显示文摘 | Reuiter N | 1989 | Toxicol Lett1989，47，： | 1 |
| 5 | DNA immunization of dairy cows with the clumping factor A of Staph- ylococcus aureus显示文摘 | ADEL N M NOUR EL-DIN LULZIM SHKRETA BRIAN G TALBOT | 2006 | Vaccine2006，24，： | 1 |
| 6 | Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter显示文摘 | Donald A T Adel M N William A G | 1990 | Angewandte Chemie International Edition in English1990，29，2： | 1 |
| 7 | Modeling of zinc bromide energy storage for vehicular applications 显示文摘 | EMAD M ADEL N RENTEL C H | 2010 | IEEE Transactions on Industrial Electronics2010，57，2： | 1 |
| 8 | Biosafety and biosecurity measures:management ofbiosafety level3 facilities显示文摘 | Adel N Zaki | 2010 | Internal Journal of AntimicrobialAgents2010，36，1： | 1 |
| 9 | Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time显示文摘 | van Adel BA Kostic C Deglon N | 2003 | Hum Gene Ther2003，14，2： | 1 |
| 10 | Typing of Haemophilus parasuis strains by PCR-RFLP analysis of the tbpA gene显示文摘 | Puente R V A Navas M J Garcíadel B N | 2003 | Vet Microbiol2003，92，3： | 1 |
| 11 | Bioequivalence evaluation of two brands of enalapril 20 mg tablets (Narapril and Renitec) in healthy human volunteers显示文摘 | Najib NM Idkaidek N Adel A | 2003 | Biopharm Drug Dispos2003，24，7： | 1 |
| 12 | Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time显示文摘 | van ADEL B A KOSTIC C DEGLON N | 2003 | Hum Gene Ther2003，14，： | 1 |
| 13 | DNA immunization of dairy cows with the clumping factor A of Staphylococcus aureus 显示文摘 | Nour E D Adel N M | 2006 | Vaccine2006，24，12： | 1 |
| 14 | High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy:a large retrospective analysis显示文摘 | Moore RA Adel N Riedel E | 2011 | J Clin Oncol2011，29，25： | 1 |
| 15 | Series Voltage Compensation for DFIG Wind Turbine Low-Voltage Ride-through Solution 显示文摘 | Omar A B Adel N | 2011 | IEEE Transactions on Energy Conversion2011，26，1： | 1 |
| 16 | DNA immunization of dairy cows with the Clumping factor A of Staphylococcus aureus显示文摘 | Adel N M Nour El-Din Lulzim Shkreta et at | 2006 | Vaccine2006，24，： | 1 |
| 17 | High incidence of thromboembolic events in patients treated with cisplatin-based chemotherapy: a large retrospective analysis 显示文摘 | MOORE RA ADEL N RIEDEL E | 2011 | J Clin Oncol2011，29，25： | 1 |
| 18 | Biotransformation of resveratrol:synthesis of trans-dehydrodimers catalyzed by laccases from Myceliphtora thermophyla and from Trametes pubescens显示文摘 | SILVIA N MARIA RC ADELE M | 2004 | Tetrahedron2004，60，： | 1 |
| 19 | Series voltage compensation for DFIG wind turbine low voltage ride through solution显示文摘 | Omar A B Adel N | 2011 | IEEE Transactions on Energy Converters2011，26，1： | 1 |
| 20 | Inhibition of hydroxyl radical-generated DNA degradation by metallothionein显示文摘 | Adel J de Ruiter N | 1989 | Toxicol Lett1989，47，： | 1 |
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