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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | The use of flow cytometry to detect expression of subunits encoded by 11 Salmonella enterica serotype Typhimurium fimbrial operons 显示文摘 | Humphries AD Raffatellu M Winter S Weening EA Droleskey R Zhang SP Figueiredo J Khare S Nunes J Adams LG Tsolis RM Baumler AJ | 2003 | Mol Microbiol2003，48，5： | 1 |
| 3 | Familial Sneddon's syndrome:clinical,hematologic,and radiographic findings in two brothers显示文摘 | Wassewrman BA Adams NL | 1994 | Neurology1994，44，： | 1 |
| 4 | Simultaneous lichen striatus insiblings along the same Blaschko line 显示文摘 | Racette AJ Adams AD Kessler SE | 2009 | Pediatr Dermatol2009，26，1： | 1 |
| 5 | Predicting total knee replacement pain:a prospective,observational study显示文摘 | Brander VA Stulberg SD Adams AD | | 0，，416： | 1 |
| 6 | Use of the anterior chamber maintainer in anterior segment surgery显示文摘 | Chawla HB Adams AD | 1996 | J Cataract Refract Surg1996，22，2： | 1 |
| 7 | Predicting total knee replacement pain: a prospective, observational study显示文摘 | Brander VA Stulberg SD Adams AD | 2003 | Clin Orthop Relat Res2003，416，： | 1 |
| 8 | Use of the anterior chamber maintainer in anterior segment surgery显示文摘 | Adams AD | 1996 | J Cataract Refract Surg1996，22，2： | 1 |
| 9 | Evaluation of a 2% chlorhexidine gluconate in 70% is opropylal coholsk indi sinfectant 显示文摘 | Adams AD Quayumb M Worthingtonb T | 2005 | Journal of Hospital In fection2005，61，2： | 1 |
| 10 | Guidelines for the cardiac sonographer in the performance of contrast echocardiography: recommendations of the American Society of Echocardiography Council on Cardiac Sonography 显示文摘 | Waggoner AD Ehler D Adams D | 2001 | J Am Soc Echocardiogr2001，14，5： | 1 |
| 11 | Use of the anterior chamber maintainer in anterior segment surgery显示文摘 | Chawla HB Adams AD | 1996 | J Cataract Refract Surg1996，22，2： | 1 |
| 12 | Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection显示文摘 | Miller DG Adam MA Miller AD | 1990 | Mol Cell Biol1990，10，8： | 1 |
| 13 | Expression of fascin-1 , the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis显示文摘 | Adèle De Arcangelis Elisabeth Georges-Labouesse Josephine C. Adams | 2004 | Gene Expression Patterns2004，，6： | 1 |
| 14 | Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection显示文摘 | Miller DG Adam MA Miller AD | 1994 | Mol Cell Biol1994，10，10： | 1 |
| 15 | Changes in endothelial, leucocyte and platelet markers following contrast medium injection during angiography in patients with peripheral artery disease 显示文摘 | Blann AD Adams R Ashleigh R | 2001 | Br J Radiol2001，74，885： | 1 |
| 16 | Social-cognitive predictors of intention to vaccinate against the human papillomavirus in college-age women 显示文摘 | Bennett KK Buchanan JA Adams AD | 2012 | J Soc Psychol2012，152，4： | 1 |
| 17 | Amphipathic 3-phenyl-7- propylbenzisoxazoles; human PPARγ, δ and a agonists 显示文摘 | Adams AD Yuen W Hu Z | 2003 | Bioorg Med Chem Lett2003，13，： | 1 |
| 18 | The neurological complications of dissectingaortic aneurysm 显示文摘 | Weisman AD Adams RD | 1944 | Brain1944，67，1： | 1 |
| 19 | Supplemental insurance and use of effective cardiovascular drugs among elderly medicare beneficiaries with coronary heart disease显示文摘 | Federman AD Adams AS Ross-Degnan D | 2001 | JAMA2001，286，14： | 1 |
| 20 | Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection显示文摘 | Miller DG Adam MA Miller AD | 1990 | Mol Cell Biol1990，10，8： | 1 |
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