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27篇 您的检索式:作者名="Adam RN"
    题名 作者 年代 出处 被引量
1Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation.Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes 2016World Journal of Diabetes2016,7,2:4
2Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation显示文摘Drachman DB Angus CW Adams RN 1978N Engl J Med1978,98,:1
3Rebooting the immune system with high-dose cyclophosphamide for treatment of refractory myasthenia gravis显示文摘Drachman DB Adams RN Hong R 2008Ann N Y Acad Sci2008,1132,:1
4S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population显示文摘Adam M. Zawada Kyrill S. Rogacev Bj?rn Hummel Judith T. Berg Annika Friedrich Heinz J. Roth Rima Obeid Jürgen Geisel Danilo Fliser Gunnar H. Heine 2014Atherosclerosis2014,,1:1
5Pro-survival AKTand ERK signaling from EGFR and mutant EGFRvIII enhancesDNA double-strand break repair in human glioma cells 显示文摘Golding SE Morgan RN Adams BR 2009Cancer Biol Ther2009,8,8:1
6Pathology,histochemistry and im-munocytochemistry of lesions in acute multiple sclerosis显示文摘Adams CW Poston RN Buk SJ 1989J Neu-rol Sci1989,92,:1
7Pro - survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double- strand break repair in human glioma eeUs显示文摘Golding SE Morgan RN Adams BR 2009Can- cer biology & therapy2009,8,8:1
8Rational Approximation of Frequency Domain Responses by Vector Fitting显示文摘Bjφrn Gustavsen Adam Semlyen 1999IEEE Trans On Power Delivery1999,14,3:1
9Rebooting the immune system with high-dose cyelophosphamide for treatment of refractory myasthenia gravis显示文摘Drachman DB Adams RN Hu R 2008Ann NY Acad Sci2008,1132,:1
10Iron and mycobacterium tuberculosis infection显示文摘Adams HS Nieuwenhuijsen MJ Colvile RN 2001J Clin Virol2001,20,:1
11The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry 显示文摘Cammack J Ghasemzadeh B Adams RN 1991Brain Res1991,565,:1
12Myasthenic antibod- ies cross-link acetylcholine receptors to accelerate degradation 显示文摘Drachman DB Angus CW Adams RN 1978New Engl J ned1978,298,20:1
13Rebooting the immune system with highdose cyclophosphamide for treatment of refractory myasthenia gravis显示文摘Drachman DB Adams RN Hu R Jones RJ Brodsky RA 2008Ann N Y Acad Sci2008,1132,:1
14Rebooting the immune system with high-dose cyclophosphamide for treatment of refractory myasthenia gravis显示文摘Drachman DB Adams RN Hu R 2008Ann N Y Acad Sci2008,1132,:1
15Treatment of ongoing experimental myasthenia gravis with short term high dose cyclophosphamide 显示文摘Pestronk A Draehman DB Adams RN 1982Muscle Nerve1982,5,10:1
16ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction:executive summary显示文摘Anderson JL Adams RN Antman EM 2007Circulation2007,116,:1
17Potential oxidative pathways of brain catecholamines显示文摘Tse DC McCreery RL Adams RN 1976J Med Chem1976,19,1:1
18Mental tough- ness in sport : Achievement level, gender, age, experience, and sport type differences 显示文摘Adam RN Remco CJP Andrew RL 2009Personality and Individual Differences2009,47,1:1
19Fine particle (PMzs) personal exposure levels in transport microenvironments, London,UK显示文摘Adams HS Nieuwenhuijsen MJ Colvile RN 2001Sei Total Environ2001,279,:1
20Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation显示文摘Drachman DB Angus CW Adams RN el al 1978N Engl J Med1978,298,:1
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