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| 1 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 2 | Analysis of variables and interactions among variables associated with a sustained virological response to pegylated interferon alfa-2a plus ribavirin in hepatitis C virus genotype 3-infected patients显示文摘 | Hafsa Aziz Abida Raza Yasir Waheed Uzma Gill Muzaffar Lateef Gill | 2012 | International Journal of Infectious Diseases2012，，8： | 1 |
| 3 | Evaluation of prognostic factors for Peg Interferon alfa-2b plus ribavirin treatment on HCV infected patients in Pakistan显示文摘 | Hafsa Aziz Muzaffar Latif Gil Yasir Waheed Uzama Adeeb Abida Raza Iram Bilal Muhammad Amin Athar | 2011 | Infection Genetics and Evolution2011，，3： | 1 |
| 4 | Assessment of Phytochemical Analysis,Nutritional Composition and Antimicrobial Activity of Moringa oleifera显示文摘Moringa oleifera is a miracle plant rich in nutrients,antioxidants,and antibiotic properties.Present study was designed to evaluate various biochemical attributes of leaves and flowers of M.oleifera.Plant parts(leaves,flowers)of M.oleifera,collected from different roadsides of Multan district,Punjab,Pakistan,were used as experimental material.Result indicates that alkaloids,saponin,carbohydrates,fats,and protein had a high value in the aqueous extract of both leaves and flowers of M.oleifera.Whereas phenol content was high in methanolic leaves extract and the phenol contents were high in aqueous extract of flowers.The extract yield of M.oleifera leaves and flowers both showed a higher percentage in aqueous extract(57.5%),followed by methanol extract and lowest in ethyl acetate extract.Flavonoids contents were higher in ethyl acetate extract of leaves(33.67%)and aqueous extract of flowers(53.71%).While crude fiber was high in methanolic extract of leaves(12.40%)and in flowers crude fiber was high in ethyl acetate extract(15.86%).The moisture contents were higher in leaves(8.87%)than flowers(7.3%)and similarly,ash percentage in flowers(52.60%)than leaves(41.84%).Ethyl acetate extracts of M.oleifera leaves show antibacterial activity against Pseudomonas aeruginosa while methanolic extract of M.oleifera flowers shows antibacterial activity against Xanthomonas sp.Maximum growth inhibits show in all extracts of leaves against Aspergillus flavus,F.oxysporum,and P.glabrum except for the concentrated aqueous extract of leaves.While in flowers maximum growth inhibits all extracts against P.glabrum,A.niger,and A.flavus except the diluted ethyl acetate extract.Phytochemicals present in different parts of moringa have significant edible and commercial potential.Moringa extracts exhibited significant antimicrobial activity,therefore have applications in pharmaceuticals. | Naima Asghar Abida Aziz Muhammad Farooq Azhar Mohamed El-Sharnouby Uzma Irfan Iqra Rafiq Husnain Farooq Muhammad Ishaq Asif Rehmani Mohamed I.Sakran A.Altalhi Fahad M.Alzuaibr Ayman El Sabagh | 2022 | Phyton-International Journal of Experimental Botany2022，91，8： | 1 |
| 5 | A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan显示文摘Background:Approximately 10 million people in Pakistan are infected with the hepatitis C virus(HCV).Most patients develop chronic hepatitis,with rare cases of spontaneous clearance.However,little is known about multidrug resistant viral variants in Pakistan.Findings:This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003.After an initial diagnosis of viral infection,the patient remained treatment naïve for 5 years.He received two therapy cycles of interferon(IFN)plus ribavirin(RBV)in 2007 and 2010,however,he was non-responsive to the therapy.The patient then received an additional two treatment cycles of pegylated IFNα-2b plus RBV(in 2011 and 2013);he was still non-responsive.In 2016,the patient underwent sofosbuvir plus RBV combination therapy,however,the sustained virological response was still not achieved.The host genetic factor was found to be heterozygous guanine and thymine(GT)and cytosine and thymine(CT)genotypes of rs8099917 and rs12979860 polymorphism of IL28B,respectively.Phylogenetic analysis suggests that the resistant variant belong to an out-group and may require triple therapy.Conclusions:This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in Pakistan.Further studies are needed to understand multidrug-resistant HCV variants in the Pakistani population. | Asad Zia Muhammad Ali Hafsa Aziz Muhammad Zia Zabta Khan Shinwari Abida Raza | 2018 | Infectious Diseases of Poverty2018，7，1： | 0 |
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