|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Incidence of human papilloma virus in esophageal squamous cell carcinoma in patients from the Lublin region显示文摘AIM:To assess the prevalence of human papilloma virus(HPV) in esophageal squamous cell carcinoma(ESCC) in the south-eastern region of Poland.METHODS:The study population consisted of 56 ESCC patients and 35 controls.The controls were patients referred to our department due to other nonesophageal and non-oncological disorders with no gross or microscopic esophageal pathology as confirmed by endoscopy and histopathology.In the ESCC patients,samples were taken from normal mucosa(56 mucosa samples) and from the tumor(56 tumor samples).Tissue samples from the controls were taken from normal mucosa of the middle esophagus(35 control samples).Quantitative determination of DNA was carried out using a spectrophotometric method.Genomic DNA was isolated using the QIAamp DNA Midi Kit.HPV infection was identified following PCR amplification of the HPV gene sequence,using primers MY09 and MY11 complementary to the genome sequence of at least 33 types of HPV.The sequencing results were computationally analyzed using the basic local alignment search tool database.RESULTS:In tumor samples,HPV DNA was identified in 28 of 56 patients(50%).High risk HPV phenotypes(16 or/and 18) were found in 5 of 56 patients(8.9%),low risk in 19 of 56 patients(33.9%) and other types of HPV(37,81,97,CP6108) in 4 of 56 patients(7.1%).In mucosa samples,HPV DNA was isolated in 21 of 56 patients(37.5%).High risk HPV DNA was confirmed in 3 of 56 patients(5.3%),low risk HPV DNA in 12 of 56 patients(21.4%),and other types of HPV in 6 of 56 patients(10.7%).In control samples,HPV DNA was identified in 4 of 35 patients(11.4%) with no high risk HPV.The occurrence of HPV in ESCC patients was significantly higher than in the controls [28 of 56(50%) vs 4 of 35(11.4%),P < 0.001].In esophageal cancer patients,both in tumor and mucosa samples,the predominant HPV phenotypes were low risk HPV,isolated 4 times more frequently than high risk phenotypes [19 of 56(33.9%) vs 5 of 56(8.9%),P < 0.001].A higher prevalence of HPV was identified in female patients(71.4% vs 46.9%).Accordingly,the high risk phenotypes were isolated more frequently in female patients and this difference reached statistical significance [3 of 7(42.9%) vs 2 of 49(4.1%),P < 0.05].Of the pathological characteristics,only an infiltrative pattern of macroscopic tumor type significantly correlated with the presence of HPV DNA in ESCC samples [20 of 27(74.1%) vs 8 of 29(27.6%) for ulcerative or protruding macroscopic type,P < 0.05].The occurrence of total HPV DNA and both HPV high or low risk phenotypes did not significantly differ with regard to particular grades of cellular differentiation,phases in depth of tumor infiltration,grades of nodal involvement and stages of tumor progression.CONCLUSION:Low risk HPV phenotypes could be one of the co-activators or/and co-carcinogens in complex,progressive,multifactorial and multistep esophageal carcinogenesis. | Andrzej Dabrowski Wojciech Kwasniewski Tomasz Skoczylas Wiesawa Bednarek Dorota Kuzma Anna Gozdzicka-Józefiak | 2012 | World Journal of Gastroenterology2012，18，40： | 55 |
| 2 | Synchronous and metachronous neoplasms in gastric cancer patients:A 23-year study显示文摘AIM:To determine the prevalence and characteristics of additional primary malignancies in gastric cancer(GC)patients.METHODS:GC patients(862 total;570 men,292women;mean age 59.8±12.8 years)diagnosed at the Department of Gastroenterology at Pomeranian Medical University over a period of 23 years were included in this retrospective analysis of a prospectively maintained database.Mean follow-up time was 31.3±38.6 mo(range 1-241 mo).The following clinicopathological features of patients with synchronous tumors were compared to those with metachronous tumors:age,sex,symptom duration,family history of cancer,tumor site,stage(early vs advanced),histology,and blood group.GC patients with and without a second tumor were compared in terms of the same clinicopathological features.RESULTS:Of 862 GC patients,58(6.7%)developed a total of 62 multiple primary tumors,of which 39(63%)were metachronous and 23(37%)synchronous.Four(6.9%)of the 58 multiple GC patients developed two or more neoplasms.The predominant tumor type of the secondary neoplasms was colorectal(n=17),followed by lung(n=9),breast(n=8),and prostate(n=7).Age was the only clinicopathological feature that differed between GC patients with synchronous vs metachronous malignancies;GC patients with synchronous neoplasms were older than those with metachronous neoplasms(68.0±10.3 years vs 59.9±11.1years,respectively,P=0.008).Comparisons between patients with and without a second primary cancer revealed that the only statistically significant differences were in age and blood group.The mean age of the patients with multiple GC was higher than that of those without a second primary tumor(63.4±11.4years vs 59.5±13.0 years,respectively,P=0.026).GC patients with a second primary tumor were more commonly blood group O than those without(56.2%vs 31.6%,respectively,P=0.002).CONCLUSION:GC patients may develop other primary cancers;appropriate preoperative and postoperative diagnostic modalities are thus required,particularly if patients are older and blood group O. | Magorzata Lawniczak Alicja Gawin Halina Jaroszewicz-Heigelmann Wiesawa Rogoza-Mateja Joanna Raszeja-Wyszomirska Andrzej Biaek Katarzyna Karpińska-Kaczmarczyk Teresa Starzyńska | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 3 | 波兰中医药发展现状与分析显示文摘波兰有较为完善的医疗保险体系,所有加入法定医疗保险的公民均可享受国家补贴的医疗服务。当地缺血性心脏病、脑卒中、AD发病率较高。波兰民众保健意识较强,对传统医学的接受度较高,中医药在当地有一定的发展,目前针灸治疗痛证已被纳入波兰公立医疗保险报销范畴;多种中医药协会及多所大学的孔子学院均开设了中医药课程。但发展中亦存在一定问题,如针灸以外其他疗法的治疗价值未被完全认识;在医师培训和中医教育方面缺少规范化的标准和法律法规;缺少明确的中药质量标准等。建议通过规范中医药疗法的运用、扩大医疗保险中中医的覆盖率、加强中医药疗法的推广、完善中医教育和学历认证等措施,促进两国在中医药领域的广泛合作,推动中医药在波兰的发展与传播。 | 石晗 尹雅倩 Monika Rybicka Przemysław Tomasik Magdalena Kocot-Kepska Wiesława Klimek-Piotrowska 魏竞竞 赵静 杨龙会 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，3： | 5 |
| 4 | Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor显示文摘 | Katarzyna Gardian S?awa Janczewska Marek Durlik Grazyna Rydzewska | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 5 | Geographical distribution of persistent organochlorines in air, water and sediments from Asia and Oceania and their implications for global redistribution from lower latitudes 显示文摘 | Awa R | 1994 | Environmental Pollution1994，85，： | 2 |
| 6 | L-carnitine and cancer cachexia. I. L-carnitine distribution and metabolicdisorders in cancer cachexia显示文摘 | Jaros?aw Szefel Wies?aw Kruszewski Maciej Ciesielski Mariusz Szajewski Krzysztof Kawecki Ewa Aleksandrowicz?Wrona Jerzy Jankun Wies?awa ?ysiak-Szyd?owska | 2012 | Oncology Reports2012，，1： | 2 |
| 7 | Immunophenotype of peripheral blood natural killer cells and IL ‐10 serum levels in relation to Helicobacter pylori status显示文摘 | Karolina Rudnicka Agnieszka Matusiak Eliza Miszczyk Wies?awa Rudnicka Micha? Tenderenda Magdalena Chmiela | 2013 | APMIS2013，，9： | 2 |
| 8 | Genetic enhancement of fracture repair:healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gen显示文摘 | Baltzer AWA Lattermann C Whalen JD | 2000 | Gene Therapy2000，7，： | 1 |
| 9 | Immunotherapy for advanced renal cell cancer显示文摘 | Coppin C Porzsolt F Awa A | 2005 | Cochrane Database Syst Rev2005，25，1： | 1 |
| 10 | The increase of memory T cell subsets in children with idiopathic nephritic syndrome显示文摘 | Yan K Nakahara K Awa S | 1998 | Nephron1998，79，3： | 1 |
| 11 | Effect of ethylene absorbent on polygalacturanase activity of persimmon fruit显示文摘 | Matsoi T Kitag awa H | 1989 | Journal of the Jap anese Society for Horticultural Science1989，57，4： | 1 |
| 12 | Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation 显示文摘 | Lucas JN Awa A Straume T | 1992 | Int J Radiat Biol1992，62，1： | 1 |
| 13 | The intensity of postoperative shivering isunrelated to aillary temperature显示文摘 | Crossly AWA Mahajan RP | 1994 | Anaesthesia1994，，： | 1 |
| 14 | Treatment of deep venousthrombosis with low-molecular-weigh heparius显示文摘 | IENSING AWA PRINS MH | 1995 | 155:601-6071995，155，： | 1 |
| 15 | Biochemistry of malathion resistance in Culex tarsalis显示文摘 | Matsumura F Brown AWA | 1961 | J Econ Entomol1961，54，： | 1 |
| 16 | Dose-response analyses among atomic bomb survivors exposed to low-level radiation显示文摘 | KATO H SCHULL W J AWA A | 1987 | Health Phys1987，52，5： | 1 |
| 17 | Effect of cavity margin shavings to ensure completeness of excision on local recurrence rates following breast conserving surgery 显示文摘 | Barthelmes L A1 Awa A Crawford DJ | 2003 | Eur J Surg Oncol2003，29，8： | 1 |
| 18 | Flax/Polypropylene Composites for Lightened Structures :Multiscale Analysis of Process and Fibre Parameters显示文摘 | Awa S Doumbia Mickal Castro Denis Jouannet | 2015 | Materials and Design2015，，87： | 1 |
| 19 | The natural history of deep-vein thrombosis显示文摘 | Prandoni P Lensing AWA Prins MR | 1997 | Semin Thromb Hemos1997，23，2： | 1 |
| 20 | Persons' experience of HIV/AIDS in Japan:application of Margaret Newman's theory显示文摘 | Awa M Yamashita M | 2008 | Int Nuts Rev2008，55，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员