|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori vs coronary heart disease-searching for connections显示文摘In this review,we discussed the findings and concepts underlying the potential role of Helicobacter pylori(H.pylori) infections in the initiation,development or persistence of atherosclerosis and coronary heart disease(CHD).This Gram-negative bacterium was described by Marshall and Warren in 1984.The majority of infected subjects carries and transmits H.pylori with no symptoms; however,in some individuals these bacteria may cause peptic ulcers,and even gastric cancers.The widespread prevalence of H.pylori infections and the fact that frequently they remain asymptomatic may suggest that,similarly to intestinal microflora,H.pylori may deliver antigens that stimulate not only local,but also systemic inflammatory response.Recently,possible association between H.pylori infection and extragastric disorders has been suggested.Knowledge on the etiology of atherosclerosis together with current findings in the area of H.pylori infections constitute the background for the newly proposed hypothesis that those two processes may be related.Many research studies confirm the indirect association between the prevalence of H.pylori and the occurrence of CHD.According to majority of findings the involvement of H.pylori in this process is based on the chronic inflammation which might facilitate the CHDrelated pathologies.It needs to be elucidated,if the infection initiates or just accelerates the formation of atheromatous plaque. | Magdalena Chmiela Adrian Gajewski Karolina Rudnicka | 2015 | World Journal of Cardiology2015，7，4： | 33 |
| 2 | Structural modifications of Helicobacter pylori lipopolysaccharide:An idea for how to live in peace显示文摘In this review,we discuss the findings and concepts underlying the'persistence mechanisms'of Helicobacter pylori(H.pylori),a spiral-shaped,Gram-negative rod bacterium that was discovered as a gastric pathogen by Marshall and Warren in 1984.H.pylori colonizes the gastric mucosa of nearly half of the human population.Infections appear in early childhood and,if not treated,persist for life.The presence or absence of symptoms and their severity depend on multiple bacterial components,host susceptibility and environmental factors,which allow H.pylori to switch between pathogenicity and commensalism.Many studies have shown that H.pylori components may facilitate the colonization process and the immune response of the host during the course of H.pylori infection.These H.pylori-driven interactions might result from positive or negative modulation.Among the negative immunomodulators,a prominent position is occupied by a vacuolating toxin A(VacA)and cytotoxin-associated gene A(CagA)protein.However,in light of the recent studies that are presented in this review,it is necessary to enrich this panel with H.pylori lipopolysaccharide(LPS).Together with CagA and VacA,LPS suppresses the elimination of H.pylori bacteria from the gastric mucosa by interfering with the activity of innate and adaptive immune cells,diminishing the inflammatory response,and affecting the adaptive T lymphocyte response,thus facilitating the development of chronic infections.The complex strategy of H.pylori bacteria for survival in the gastric mucosa of the host involves both structural modifications of LPS lipid A to diminish its endotoxic properties and the expression and variation of Lewis determinants,arranged in O-specific chains of H.pylori LPS.By mimicking host components,this phenomenon leaves these bacteria'invisible'to immune cells.Together,these mechanisms allow H.pylori to survive and live for many years within their hosts. | Magdalena Chmiela Karolina Rudnicka Eliza Miszczyk | 2014 | World Journal of Gastroenterology2014，20，29： | 15 |
| 3 | Immunophenotype of peripheral blood natural killer cells and IL ‐10 serum levels in relation to Helicobacter pylori status显示文摘 | Karolina Rudnicka Agnieszka Matusiak Eliza Miszczyk Wies?awa Rudnicka Micha? Tenderenda Magdalena Chmiela | 2013 | APMIS2013，，9： | 2 |
| 4 | Quantifying effect of statins on low density lipoprotein cholesterol,ischaemic heart disease,and stroke:systematic review and meta-analysis显示文摘 | LAW M R WALD N J RUDNICKA A R | 2003 | BMJ2003，326，7404： | 1 |
| 5 | Comma hairs: a dermatoscopic marker for tinea capitis: a rapid diagnostic method 显示文摘 | Slowinska M Rudnicka L Schwartz RA | 2008 | J Am Acad Dermatol2008，59，5： | 1 |
| 6 | Quantifying effect of statins on low density lipoprotein cholesterol , ischaemic heart disease,and stroke : systematic review and meta-analysis 显示文摘 | Law MR Wald NJ Rudnicka AR | 2003 | BMJ2003，326，： | 1 |
| 7 | Cutaneous ad- verse reactions of amiodarone显示文摘 | Jaworski K Walecka I Rudnicka L | 2014 | Med Sci Monit2014，21，20： | 1 |
| 8 | Second-trimester prenatal screening markers for Down syndrome in women with insulin-dependent diabetes mellitus显示文摘 | Huttly W Rudnicka A Wald NJ | 2004 | Prenat Diagn2004，24，10： | 1 |
| 9 | Weakness of cellular response to Listeria antigens in pregnant mice 显示文摘 | Rozalska B Rudnicka W | 1993 | Med Dosw Mikrobiol1993，45，1： | 1 |
| 10 | Refractive and corneal astigmatism in white school children in northern ireland显示文摘 | O' Donoghue L Rudnicka AR McClelland JF Logan NS Owen CG Saunders KJ | | 0，，07： | 1 |
| 11 | Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis 显示文摘 | Rudnicka AR Jarrar Z Wormald R | 2012 | Ophthalmology2012，119，3： | 1 |
| 12 | The prevalence of stroke in patients with obstructive sleep apnoea 显示文摘 | Rudnicka A Ptywaczewski R Jonczak L | 2010 | Pneumonol Alergol Pol2010，78，2： | 1 |
| 13 | Childhood ethnic differences in ametropia and ocular biometry:the Aston Eye Study显示文摘 | Logan NS Shah P Rudnicka AR Gilmartin B Owen CG | 2011 | Ophthalmic Physiol Opt2011，31，5： | 1 |
| 14 | Quantifying effect of statins on low density lipoprotein cholesterol,ischaemic heart disease,and stroke:systematic review and meta-analysis显示文摘 | Law MR Wald NJ Rudnicka AR | 2003 | BMJ2003，326，： | 1 |
| 15 | Quantifying effect of statins on low density lpoprotein cholesterol,ischaemic heart disease,and strok:systematic reviw and meta-anlysis显示文摘 | Law MR Wald NJ Rudnicka AR | 2003 | BMJ2003，326，7404： | 1 |
| 16 | Quantifying effect ofstatins on low density lipoproteinchoiesterol? ischaemicheart disease,and stroke:systematicreview and meta-analysis显示文摘 | Law MR Wald NJ Rudnicka AR | 2003 | BMJ2003，326，： | 1 |
| 17 | The role of heparan sulphate-binding activity of Helicobacter pylori bacteria in their adhesion to murine macrophages显示文摘 | Chmiela M Paziak-Domanska B Rudnicka W | 1995 | APMIS1995，103，6： | 1 |
| 18 | Combined intraarteriaL/intrave- nous thrombolysis for acute ischemic stroke 显示文摘 | Keris V Rudnicka S Vorona V | 2001 | AJNR2001，22，2： | 1 |
| 19 | Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive pro- tein, tissue plasminogen activator,and yon Willebrand factor in a 45-year-old population 显示文摘 | Rudnicka AR Rumley A Lowe GD | 2007 | Circulation2007，115，8： | 1 |
| 20 | Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis 显示文摘 | Rudnicka AR Mt-Isa S Owen CG | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员