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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Avian color perception predicts behavioral responses to experimental brood parasitism in chaffinches显示文摘 | Avilés JM Vikan JR Fossoy F Antonov A Moksnes A R(o)skaft E Stokke BG | | 0，，： | 1 |
| 3 | Nasal NK/T - cell lymphoma with disseminated disease treated with aggressive combined therapy显示文摘 | Aviles A Neri N Fernandez R | 2003 | Med Oncol2003，20，1： | 1 |
| 4 | The double jcopardy of diabetes and renal insufficiency in acute coronary syndromes 显示文摘 | Askari AT Aviles R J Gurm HS | 2001 | Circulation2001，104，17： | 1 |
| 5 | Imnmnotactoid glomerulopathy in sickle cell anemia 显示文摘 | Aviles D H Craver R Warrier R P | 2001 | Pediatr Nephrol2001，16，1： | 1 |
| 6 | Conformal deformations of complete manifolds with negative curvature 显示文摘 | AVILES P MCOWEN R | 1985 | J Diff Geom1985，21，： | 1 |
| 7 | Statins promote potent systemic antioxid effects through specific inflammatory pathways显示文摘 | SHISHEHBOR M H BRENNAN M L AVILES R J | 2003 | Circulation2003，108，4： | 1 |
| 8 | Nasal NK/T cell lymphoma with disseminated disease treated with aggressive combined therapy显示文摘 | Aviles A Neri N Fernandez R | 2003 | Med Oncol2003，20，1： | 1 |
| 9 | Inflammation as a risk factor for atrial fibrillation显示文摘 | AVILES R J MARTIN D O APPERSON-HANSEN C | 2003 | Circulation2003，108，： | 1 |
| 10 | Mesh migration following repaiar of inguinal hernia: a case report and review of literature 显示文摘 | Agrawal A Avill R | 2006 | Hernia2006，10，1： | 1 |
| 11 | Inflammation as a risk factor for atrial fibrillation 显示文摘 | Aviles R J Martin DO Apperson-Hansen C | 2003 | Circulation2003，108，24： | 1 |
| 12 | Inflammation as a risk factor for atrial fibrillation 显示文摘 | Aviles R J Martin DO Apperson-Hansen C | 2003 | Circulation2003，108，： | 1 |
| 13 | Applied potential tomography:A new non invasive technique for measuring gastric function显示文摘 | Mangnall YF Baxter AJ Avill R | 1987 | Clin Phys Physiol Meas1987，8，： | 1 |
| 14 | Antcrior urethral strictures: etiology and characteristics 显示文摘 | FENTON AS MOREY AF AVILES R | 2005 | Urology2005，65，： | 1 |
| 15 | Crackpath in foam cored DCB sandwich fracture specimens显示文摘 | Carlsson L A Matteson R C Aviles F Loup D C | 2005 | Composites Science and Technology2005，65，1516： | 1 |
| 16 | Inflammationas risk fac- tor for atrial fibrillation 显示文摘 | ] Aviles R J Martin D O Apperson H C | 2003 | Circulation2003，108，12： | 1 |
| 17 | Inflam- mation as a risk factor for atrial fibrillation显示文摘 | Aviles R J Martin DO Apperson-Han-Sen C | 2003 | Circulation2003，108，24： | 1 |
| 18 | Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy显示文摘 | Aviles R J Brennan ML | 2003 | JAMA2003，289，13： | 1 |
| 19 | Pigmented axillary nodule:carcinoma of an ectopic axillarybreast显示文摘 | Avilés Izquierdo JA Martínez Sánchez D Suárez Fernandez R etal | 2005 | Dermatol Surg2005，31，2： | 1 |
| 20 | Judder vibration in disc brakes excited by thermoelastie instability显示文摘 | Altuzarra O Amezua E Aviles R | 2002 | Engineering computations2002，19，4： | 1 |
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