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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Leaf respiration of show gum in light and dark interaction between temperature and irradiance 显示文摘 | ATKIN O K EVANS J R BALL M C | 2000 | Plant Physiology2000，122，： | 1 |
| 3 | Influence of the carrier on the catalytic performance of impregnated phosphoric acid in the hydration of ethylene显示文摘 | atkins M P Wolderich W F | 1999 | Applied catalysis A:general1999，181，1： | 1 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Anatomy of pilon fractures of the distal tibia显示文摘 | Topliss CJ Jackson M Atkins RM | 2005 | J Bone Joint Surg Br2005，87，5： | 1 |
| 6 | Joint optimization of ma- intenance and inventory policies for a simple system显示文摘 | ARMSTRONG M ATKINS D | 1996 | lie Transactions1996，28，5： | 1 |
| 7 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 8 | TGF - 13 in the context of an inflammatory cytokine milieu supports de novo differentia- tion ofiL- 17 producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，5： | 1 |
| 9 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 10 | QoS negotiation in real-time systems and its applications to automated flight control 显示文摘 | Atdelzater T F Atkins E M Shin K G | 2000 | IEEE Trans on Computers2000，49，11： | 1 |
| 11 | The valid use of utility in adaptive real-time systems 显示文摘 | PRASAD D BURNS A ATKINS M | 2003 | Real-Time System2003，25，23： | 1 |
| 12 | The role of appropriability in sustaining competitive advantage-An electronic auction system case study 显示文摘 | Atkins M H | 1998 | Journal of Strategic Information Systems1998，7，： | 1 |
| 13 | Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer显示文摘 | ATKINS M REGAN M MCDERMOTT D | 2005 | Clin Cancer Res2005，11，： | 1 |
| 14 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 15 | TGF-beta in the context of an inflammatory cytokine milieu supports de novo dif- ferentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking RJ Atkins CJ et 01 | 2006 | Immunity2006，24，2： | 1 |
| 16 | TGF - beta in the context of an infla - mmatory cytokine milieu sup- ports de novo differentiation of IL - 17 - producing T cells 显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 17 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 18 | Joint optimization of maintenance and inventory policies for a simple system显示文摘 | Armstrong M J Atkins D R | 1996 | IIE Transactions1996，28，5： | 1 |
| 19 | TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17 produing T cells显示文摘 | Veldhoen M Hocking RJ Atkins CJ | 2006 | Immunity2006，24，： | 1 |
| 20 | Interleukin -6 as an anti-inflammatory cytokine : induction of circulating IL - 1 receptor antagonist and soluble tumor necrosis factor receptor p55 显示文摘 | TILG H TREHU E ATKINS M B | 1994 | Blood1994，83，1： | 1 |
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