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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 3 | 子痫前期:病理生理学和临床意义显示文摘子痫前期是一种常见疾病,尤其影响首次妊娠。其临床表现多样,但通常表现为高血压和蛋白尿。这些全身症状是由于在合体滋养细胞的压力作用下,胎盘释放了可溶性因子。子痫前期主要有早发型和迟发型2种亚型,其他几种亚型目前尚未确定。早发型子痫前期是由于胎盘缺陷而出现,而迟发型子痫前期可能是由于胎盘的正常衰老,以及母体对心血管和代谢疾病的遗传易感性交互产生。子痫前期因胎盘和母体因素产生的原因因人而异。最近的研究主要集中在早孕期的胎盘-子宫相互作用。本文旨在对关于子痫前期的预测、预防和治疗方法的最新文献进行归纳综述。 | Graham J Burton Christopher W Redman James M Roberts Ashley Moffett 秦萌(译) 金滢 潘凌亚(校 | 2019 | 英国医学杂志中文版2019，22，11： | 6 |
| 4 | Hospitalized prevalence and 5-year mortality for IBD:Record linkage study显示文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency. | Lori A Button Stephen E Roberts Michael J Goldacre Ashley Akbari Sarah E Rodgers John G Williams | 2010 | World Journal of Gastroenterology2010，16，4： | 3 |
| 5 | Alcoholic hepatitis: The pivotal role of Kupffer cells显示文摘Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis(AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides(LPS). LPS binds to LPS-binding proteins and presents it to a membrane glycoprotein called CD14, which then activates Kupffer cells via a receptor called tolllike receptor 4. This endotoxin mediated activation of Kupffer cells plays an important role in the inflammatory process resulting in alcoholic hepatitis. There is no effective treatment for AH, although notable progress has been made over the last decade in understanding the underlying mechanism of alcoholic hepatitis. We specifically review the current research on the role of Kupffer cells in the pathogenesis of AH and the treatment strategies. We suggest that the imbalance between the pro-inflammatory and the anti-inflammatory process as well as the increased production of reactive oxygen species eventually lead to hepatocyte injury, the final event of alcoholic hepatitis. | Duminda B Suraweera Ashley N Weeratunga Robert W Hu Stephen J Pandol Richard Hu | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 3 |
| 6 | Bilateral renal cortical necrosis associated with smoking synthetic cannabinoids显示文摘Synthetic cannabinoids have become a common drug of abuse in recent years and their toxicities have come to light as well. They are known to be notorious for the kidneys, with acute tubular necrosis, acute interstitial nephritis and rhabdomyolysis induced renal injury being the frequent nephrotoxic outcomes in users. We report a case of bilateral renal cortical necrosis, leading to irreversible renal damage and lifelong dialysis dependency. | Kanaan Mansoor Ashley Zawodniak Tibor Nadasdy Zeid J Khitan | 2017 | World Journal of Clinical Cases2017，5，6： | 2 |
| 7 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 8 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 9 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 10 | Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance(CURES-32)显示文摘 | Surendar J Anuradha S Ashley B | 2009 | Metab Syndr Relat Disord2009，7，5： | 1 |
| 11 | The association of chemotherapy induced neutropenia on treatment outcomes in small ceLl lung cancer显示文摘 | Banerji U Ashley S Coward J | 2006 | Lung Cancer2006，54，3： | 1 |
| 12 | The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo显示文摘 | Powers J Chen M | 2005 | Cardiovasc Res2005，65，1： | 1 |
| 13 | The endogenous peptide Apelin potently improves cardiac contractility and reduces cardiac loading in vivo显示文摘 | Ashley EA Powers J Chen M | 2005 | Cardiovas Res2005，65，1： | 1 |
| 14 | Urachal anomalies:a lon- gitudinal study of uraehal remnants in children and adults显示文摘 | Ashley R A Inman B A Routh J C | 2007 | JUrol2007，178，4： | 1 |
| 15 | Basal-like breast carcinomas:clinical outcome and response to chemotherapy显示文摘 | BANERJEE S REIS FILHO J S ASHLEY S | 2006 | J Clin Pathol2006，59，7： | 1 |
| 16 | Good clinical response of breast cancers to neoadjuvant chemoendocfine therapy is associatedwith improved overall survival显示文摘 | Cleator S J Makris A Ashley S E | 2005 | Ann Oncol2005，16，2： | 1 |
| 17 | Selective targeting of RANK signa- ling pathways as new therapeutic strategies fir osteoporosis 显示文摘 | Jules J Ashley JW Feng X | 2010 | Ex- pert Opin Ther Targets2010，9，： | 1 |
| 18 | Electrostatically mediated liposome fusion and lipid exchange with a nanoparticle-supported bilayer for control of surface charge, drug containment, and deliver 显示文摘 | Liu J Jiang X Ashley C | 2009 | J Am Chem Soc2009，131，22： | 1 |
| 19 | Outpatient Pulmonary rehabililation in sever chronic obstructive pulmonary rehabililation disease显示文摘 | White RT Rudkin ST Ashley J | 1997 | J R Coil Physicians Lond1997，31，5： | 1 |
| 20 | Basal -like breast carcino- mas : clinical outcome and response to chemotherapy 显示文摘 | Banerjee S Reis -Filho J S Ashley S | 2006 | J Clin Pathol2006，59，7： | 1 |
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